Univ. of Pittsburgh Medical Center leads group buying PPL'S cloning, stem cell business

th hyperacute rejection, thus removing a major immune barrier between pig and human and making transplants from animals to humans more feasible.

In January 2002, PPL announced the birth of pigs lacking one copy of this gene for the enzyme alpha1, 3 galactosyl transferase (alpha-gal), which adds a sugar to the surface of cells that the human immune system immediately recognizes as being foreign. Then in August of that year, PPL announced the birth of a litter of double-knockout pigs, each lacking both copies of the gene responsible for making the alpha-gal enzyme.

In recent studies performed by the PPL and Pittsburgh teams and reported in Science, cells taken from one of these double-knockout pigs did not elicit the usual hyperacute rejection response when transplanted into mice. These results and a description of the double-knockout pigs were published on the journal's Web site Dec. 19, 2002.

"It was fortuitous in many ways that we were able to establish a collaboration with PPL when we did. Indeed, the molecular biology work of Dr. Koike and others at the University of Pittsburgh provided PPL with an important piece to the puzzle that allowed their accomplishments with gene deletion to occur. In my opinion, it seems even more fortuitous that these teams can continue to work together, as their prior work will form the basis for moving forward into the future, and our team's recent discoveries related to the mechanisms of human engraftment and tolerance enhances an already impressive store of intellectual talent," noted John J. Fung, M.D., Ph.D., the Thomas E. Starzl Professor of Transplantation Surgery at the University of Pittsburgh School of Medicine and director of the Thomas E. Starzl Transplantation Institute.

According to Regenecor, there are currently five double-knockout pigs from two litters, three from a litter born in July 2002 and two that were born in September. Additionally, pregnancies from breeding of several singl

Contact: Lisa Rossi
University of Pittsburgh Medical Center

Page: 1 2 3 4 5

Related biology news :

1. Novel IBD therapeutic approaches reported from Washington Univ., Barcelona, LSU at APS meeting
2. Univ. of Pittsburgh receives $6.3M NIH grant to study oral health disparities in Appalachia
3. Univ. of Fla. professor: Air cleaning system destroys Anthrax, other pathogens
4. University of Pittsburgh receives $10 million grant for head and neck cancer
5. University of Pittsburgh medical center among first to implant heart assist device
6. University of Pittsburgh receives NIH funding to develop heart assist device for infants
7. Pittsburgh NMR Center for Biomedical Research at Carnegie Mellon
8. University of Pittsburgh Medical Center acquires biotechnology firm Rheogene Inc.
9. Pittsburgh researchers engineer and successfully test SARS corona vaccine in animal model
10. Protein biomarkers accurately and quickly diagnose ALS, find Pittsburgh researchers
11. University of Pittsburgh scientist honored for major accomplishment in cancer research

Post Your Comments:

(Date:6/13/2019)... ... June 13, 2019 , ... Global Clinical and Ancillary ... end-to-end clinical and ancillary supply chain management needs of large- and middle-market pharmaceutical, ... today announced it will sponsor a summer education program offered by the Young ...
(Date:6/6/2019)... ... June 05, 2019 , ... ... opening of a new network station and service center in Mexico City, Mexico. ... in the world — with more than $1.75 billion in pharmaceutical exports since ...
(Date:6/4/2019)... ... June 04, 2019 , ... Harper was three years ... X-rays revealed severe elbow dysplasia, which caused painful osteoarthritis in the joints. She ... Her parents were heartbroken. , The surgical specialist, Dr. Christopher Eich of Southern ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... Redwood City, California (PRWEB) , ... ... ... received allowance of our patent applications from the USPTO providing proprietary interest ... SYSTEM AND METHOD FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP ...
(Date:5/21/2019)... ... May 21, 2019 , ... ... today officially opened the inaugural Africa Brewing Conference dedicated to sharing brewing knowledge, ... Africa. The event, which is supported through a partnership with “Ethiopia Invest”, will ...
(Date:5/8/2019)... ... ... at 16.2 hands, Atlas is on the large side for a Quarter Horse. He ... other activities. When loping around a corner in late 2017, Atlas tripped and partially ... only being able to walk. Fortunately Atlas’ owner, Kelly, sought the opinion of her ...
(Date:5/2/2019)... ... 2019 , ... The centuries old practice of brewing beer thrives today across ... and even home brewing clubs scattered across the nation. , But proper beer ... can produce a superb product. Students at South Dakota School of Mines & ...
Breaking Biology Technology:
Cached News: