HOME >> BIOLOGY >> NEWS
University Of Kentucky Chandler Medical Center Researchers Identify Protein That,,May Cause Nerve Cell Death In Alzheimer's Disease

LEXINGTON, KY (August 3, 1998) -- A team of University of Kentucky Chandler Medical Center researchers has recently discovered that Par-4, a protein, may lead to nerve cell death in Alzheimer's disease and related brain disorders. Announced in the August issue of Nature Medicine, the research results show an increased level of the protein -- Par-4 -- in nerve cells in the brains of Alzheimer's disease patients, suggesting the protein may be a contributing factor to the disease.

Blocking Par-4 might be useful as a future treatment for the disease, said Mark Mattson, Ph.D., UK professor of anatomy and neurobiology. "The study's findings identify a new molecular target upon which to aim the emerging arsenal of weapons in the battle against Alzheimer's disease," Mattson said.

Par-4 may play a critical role in nerve cell death in Alzheimer's disease and related brain disorders. Cell death is a fundamental problem in age-related neurodegenerative disorders -- in Alzheimer's disease, nerve cells critical for learning and memory die.

Previous studies have shown that nerve cells in the brains of Alzheimer's patients die by apoptosis, a term used to describe programmed cell death. During the process of apoptosis, a cell shrinks and its DNA (string-like molecules that make up genes) becomes broken into small pieces. Each gene in DNA carries the information required to produce one specific protein. When the gene is expressed, or "switched on," the protein is made. During apoptosis, genes are activated that encode "killer proteins," and these proteins signal cells to begin dying.

The identity of the "killer proteins" and their place in the cascade of events leading to cell death has been a mystery to scientists for decades. The current research may fill one more piece in the puzzle.

Vivek Rangnekar, Ph.D., associate professor of microbiology and immunology, UK College of Medicine, discovered the gene that codes for Par-4 in 1993.
'"/>

Contact: Kim Cumbie
krcumb0@pop.uky.edu
(606) 323-6363
University of Kentucky Medical Center
4-Aug-1998


Page: 1 2 3 4

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. University of Alberta researcher looks for clues to mysterious disease
3. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
4. Washington University in St. Louis leads group studying aging process
5. Tufts University establishes $4 million dollar tissue engineering resource center
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. As informatics grows, Indiana University helps set research agenda
8. University of Arizona licenses patent for natural fungicide
9. Washington University in St. Louis plays key role in sequencing moss genome
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. Clemson University spin-off uses corn to make plastics, provide cleaner air

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/15/2016)... 2016 Yissum Research Development Company of ... of the Hebrew University, announced today the formation of ... of various human biological indicators. Neteera Technologies has completed ... private investors. ... of electromagnetic emissions from sweat ducts, enables reliable and ...
(Date:3/11/2016)... http://www.apimages.com ) - --> http://www.apimages.com ) - ... ( http://www.apimages.com ) - Germany . The ... refugee identity cards. DERMALOG will be unveiling this device, and a ... next week.   --> Germany . ... new refugee identity cards. DERMALOG will be unveiling this device, and ...
(Date:3/10/2016)... BELL, Pa. , March 10, 2016   Unisys ... U.S. Customs and Border Protection (CBP) is testing its ... San Diego to help identify certain ... States . The test, designed to help determine the ... pedestrian environment, began in February and will run until May ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... April 27, 2016 , ... ... its Scientific Advisory Board. Dr. Lamka will assist PathSensors in expanding the use ... , PathSensors deploys the CANARY® test platform for the detection of harmful pathogens, ...
(Date:4/27/2016)... -- MedDay, a biotechnology company focused on the ... Catherine Moukheibir as Chairman of its Board of Directors. ... Garaud , who contributed to the rapid development of the ... Catherine started her career in strategy consulting and investment banking ... .  She held C-Suite level roles in some of ...
(Date:4/26/2016)... ... April 26, 2016 , ... The European Patent Office ... as one of three finalists for the European Inventor Award 2016 in the category ... will be announced at a ceremony in Lisbon on June 9th. , The human ...
(Date:4/26/2016)... , ... April 26, 2016 , ... BioFactura, Inc ... Series A round of financing. Healthy investor interest drove significant oversubscription of the ... generic biologics, known as biosimilars, to the advanced preclinical stages. , Chief Executive Officer ...
Breaking Biology Technology:
Cached News: