HOME >> BIOLOGY >> NEWS
University Of Kentucky Chandler Medical Center Researchers Identify Protein That,,May Cause Nerve Cell Death In Alzheimer's Disease

He demonstrated several years ago that Par-4 was conspicuously present in prostate cancer cells undergoing apoptosis as a result of androgen(testosterone) removal. Testosterone removal is a common treatment for prostate cancer that can reduce the formation of tumors of the prostate gland in humans.

Rangnekar said that Mattson became aware of his cancer research and suggested that Par-4 might play a role in the same molecular processes that occur in neurodegenerative disorders.

To investigate the protein's effects, Mattson and Qing Guo, Ph.D., genetically engineered nerve cell cultures that blocked the ability of the Par-4 protein to function. The cells became remarkably resistant to death.

"This suggests the necessity of the Par-4 gene in the molecular cascade of events that signals the beginning of cell death," Mattson said. "Our cell culture data demonstrate that Par-4 is expressed during the early stages of the cell death process."

Factors such as environmental stimulants and genetic predisposition might trigger the cell death chain of events. Once set into motion, other genes and proteins help trigger the "switches" to signal cell death. Mattson and Rangnekar continued to pursue other factors that might interact with Par-4.

In earlier studies, Mattson's team gathered evidence that a protein called amyloid-beta protein, which abnormally accumulates in the brains of Alzheimer's patients by forming structures called plaques, can cause apoptosis in cultured rat and human neurons. Amyloid-beta protein increases free radical levels in cells and disrupts the ability of nerve cells to maintain proper calcium levels -- both are contributors to cell demise.

Cell culture experiments in the present study demonstrated that Par-4 made nerve cells more vulnerable to being killed by amyloid-beta protein, and that levels of free radicals and calcium were increased within the cells. When Par-4 was blocked,
'"/>

Contact: Kim Cumbie
krcumb0@pop.uky.edu
(606) 323-6363
University of Kentucky Medical Center
4-Aug-1998


Page: 1 2 3 4

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. University of Alberta researcher looks for clues to mysterious disease
3. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
4. Washington University in St. Louis leads group studying aging process
5. Tufts University establishes $4 million dollar tissue engineering resource center
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. As informatics grows, Indiana University helps set research agenda
8. University of Arizona licenses patent for natural fungicide
9. Washington University in St. Louis plays key role in sequencing moss genome
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. Clemson University spin-off uses corn to make plastics, provide cleaner air

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... 2017 Today, American Trucking Associations announced ... face and eye tracking software, became the newest ... "Artificial intelligence and advanced sensing ... a driver,s attentiveness levels while on the road.  ... detect fatigue and prevent potential accidents, which could ...
(Date:5/23/2017)... the first robotic gym for the rehabilitation and functional motor sense evaluation ... Genoa, Italy . The first 30 robots will be available from ... . The technology was developed and patented at the IIT laboratories ... Technology thanks to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:5/6/2017)... , May 5, 2017 ... just announced a new breakthrough in biometric authentication ... exploits quantum mechanical properties to perform biometric authentication. These ... smart semiconductor material created by Ram Group and ... finance, entertainment, transportation, supply chains and security. Ram ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... (ADC) therapeutics, today confirmed licensing rights that give it exclusive global access ... developed in collaboration with Children’s Hospital Los Angeles (CHLA). Additionally, an ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... business process optimization firm for the life sciences and healthcare industries, announces a ... in San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree Wellness ... targeting the needs of consumers who are incorporating medical marijuana into their wellness ... Arizona. , As operators of two successful Valley dispensaries, The Giving Tree’s two ...
(Date:10/6/2017)... ... October 06, 2017 , ... The HealthTech Venture ... sector at their fourth annual Conference where founders, investors, innovative practitioners and collaborators ... ELEVATE pitch competition showcasing early stage digital health and med tech companies. , ...
Breaking Biology Technology:
Cached News: