University Of North Carolina At Chapel Hill Scientists Find Breast Cancer Gene Required To Correct Certain GeneticDamage

CHAPEL HILL - A tumor-suppressor gene involved in breast and ovarian cancer susceptibility plays a central role in one of the body's most important mechanisms for repairing DNA when that genetic material becomes damaged, University of North Carolina at Chapel Hill researchers have discovered.

Using specially altered mouse embryo cells deficient in the gene BRCA1, the scientists found the gene directly or indirectly participates in what is called transcription-coupled repair.

"BRCA1's exact role is currently unknown, but it seems to be involved in a variety of cellular functions," said Dr. Steven A. Leadon, professor of radiation oncology at the UNC-CH School of Medicine. "This new work is important for two reasons. First, it provides probably the most direct evidence that BRCA1 is involved in DNA repair. Second, it will give us and others a useful assay, or test, to look at functional changes in the gene."

Such information is critical to knowing how cancer starts and how it might be prevented or treated more effectively, he said. Leadon compared it to understanding what various parts of a car engine do before being able to fix it.

A report on the research appears in the Aug. 14 issue of the journal Science. Besides Leadon, a member of the UNC Lineberger Comprehensive Cancer Center, authors are graduate student Lori Gowen, technicians Anna V. Avrutskaya and Anne M. Latour and Dr. Beverly H. Koller, research assistant professor of medicine.

Leadon said his laboratory has studied transcription-coupled repair for more than a decade. In that process, damage to active genes, which continuously produce proteins critical to cell function, are repaired more rapidly than damage in inactive or less active genes.

"So the cell has prioritized which regions of the genome, or total set of genes, it wants to fix first and does it through transcription

Contact: David L. Williamson
(919) 962-8596
University of North Carolina at Chapel Hill

Page: 1 2

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. University of Alberta researcher looks for clues to mysterious disease
3. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
4. Washington University in St. Louis leads group studying aging process
5. Tufts University establishes $4 million dollar tissue engineering resource center
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. As informatics grows, Indiana University helps set research agenda
8. University of Arizona licenses patent for natural fungicide
9. Washington University in St. Louis plays key role in sequencing moss genome
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. Clemson University spin-off uses corn to make plastics, provide cleaner air

Post Your Comments:

(Date:8/5/2020)... , ... August 05, 2020 , ... Regenative Labs has ... new innovations, CoreText™ and ProText™, making them the first Wharton’s jelly allografts to be ... a syringe. The company’s solutions are the first Wharton’s jelly allograft product to be ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... effectiveness of the Invictus Medical Neoasis™ active noise control device to attenuate typical ... that the Neoasis™ device attenuated the alarm sounds from patient monitors, ventilators and ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. ... Neihulizumab, a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at ... Paul J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... ... today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as its Chief ... clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson serves as an ...
(Date:7/1/2020)... (PRWEB) , ... June 29, 2020 , ... ... year to date growth of 40% in 2020, despite many obstacles created as ... MedShift aims to increase revenue for its partnered medical practices and medical manufacturers ...
(Date:6/28/2020)... ... June 25, 2020 , ... The Indoor Lab, a leading ... Space™ for businesses of all types to ensure cleanliness, distancing and occupancy with its ... A Safe Space™ enabled business will provide a health performance index system that scores ...
(Date:6/28/2020)... ... June 26, 2020 , ... ... security solutions providers, today announced its strong opposition to the recently introduced bicameral ... impose a blanket ban on most federal use of nearly all biometric and ...
Breaking Biology Technology:
Cached News: