HOME >> BIOLOGY >> NEWS
University Of Pittsburgh Scientist Discovers How A Novel Vitamin K Stops Cancer Cell Growth

PITTSBURGH, June 1 -- Scientists at the University of Pittsburgh have discovered how a novel form of vitamin K exerts its cancer-killing effects in primary liver cancers, which are notoriously resistant to chemotherapy. The research results, published in the May issue of The Journal of Biological Chemistry, describe an important new way to treat, and possibly prevent, cancer by triggering programmed cell death.

"Our finding is extremely important if we are to maximize the use of vitamin K compounds against cancer," noted Brian Carr, M.D., Ph.D., FRCP, professor of surgery in the Thomas E. Starzl Transplantation Institute and director of the Liver Cancer Center at the University of Pittsburgh Cancer Institute (UPCI). "Through our ongoing research, we now know that the vitamin K compounds not only can kill liver cancers, but also can destroy other types of cancer in tissue cultures, including breast cancer and melanoma. They do so by a quite novel growth-regulating mechanism."

"One of the attractive features of this unique compound is that it appears to stop cancer cell growth without producing toxicity. We now are testing this compound against cancers in rats, and given positive results, we hope to begin clinical trials of this agent within two years."

The Pitt research team found that a vitamin K analog, Compound 5 (Cpd 5), causes an imbalance in the normal activity of enzymes that control the addition or removal of small molecules called phosphate groups from selected proteins inside cells. Specifically, Cpd 5 blocks the activity of enzymes called protein-tyrosine phosphatases, which normally remove phosphate groups from selected proteins inside liver cancer cells. However, Cpd 5 does not interfere with another group of enzymes called protein tyrosine-kinases, which add phosphate groups to these same proteins. The result is an excess of what are called tyrosine phosphorylated proteins, which trigger a variet
'"/>

Contact: Lauren Ward
wardla@a1.isd.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
1-Jun-1998


Page: 1 2 3

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. University of Alberta researcher looks for clues to mysterious disease
3. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
4. Washington University in St. Louis leads group studying aging process
5. Tufts University establishes $4 million dollar tissue engineering resource center
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. As informatics grows, Indiana University helps set research agenda
8. University of Arizona licenses patent for natural fungicide
9. Washington University in St. Louis plays key role in sequencing moss genome
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. Clemson University spin-off uses corn to make plastics, provide cleaner air

Post Your Comments:
(Date:8/31/2015)... Growing need for data security ... projects to drive India biometrics market ... report, " India Biometrics Market Forecast & Opportunities, 2020 ", ... to grow at a CAGR of over 35% during 2015 ... of extensive use of biometric technology in the government sector. ...
(Date:8/31/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/st5b3m/saudi_arabia ) has announced ... Market - Growth, Trends & Forecasts (2014-2020)" report ... Biomedical Sensors market is estimated at $0.23 billion by ... 2014-2020 The near future will bring biomedical ... each individual. These sensors can be set to trigger ...
(Date:8/28/2015)... August 28, 2015 According to ... Market by Assessment Type (Pen & Paper Based, Hosted, ... Corporate Learning, Academic Research), Vertical and Region - Global ... Training Market to grow from USD 2.4 Billion in ... Compound Annual Growth Rate (CAGR) of 25.6% from 2015 ...
Breaking Biology News(10 mins):India Biometrics Market to Grow at Over 35% Through 2020, Says TechSci Research 2India Biometrics Market to Grow at Over 35% Through 2020, Says TechSci Research 3Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 3Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 4
(Date:8/31/2015)... ... August 31, 2015 , ... ... bring together supply chain risk management and resiliency practitioners with luminaries and thought ... best practices, and be recognized for their innovations and performance excellence. At that ...
(Date:8/31/2015)... 2015 MabVax Therapeutics Holdings, Inc. (OTCQB: MBVX) ... Company,s lead antibody, HuMab 5B1, will be garnering major ... the upcoming World Molecular Imaging Congress (WMIC) being held ... Researchers from the Department of Radiology at Memorial Sloan ... use of MabVax,s lead antibody as a PET imaging ...
(Date:8/31/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/53wxp3/israel_biomedical ) ... Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... Biomedical Sensors market is estimated at $0.19 billion by ... 2014-2020 The near future will bring biomedical ... each individual. These sensors can be set to trigger ...
(Date:8/31/2015)... 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage" or "the ... pleased to announce that its wholly owned subsidiary, Portage ... PPL-003, to an Investigational New Drug (IND) application for ... PPL recently completed a study in a rat model ... highly significant efficacy and a more rapid onset of ...
Breaking Biology Technology:Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 2Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 3MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 3MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 4Israel Biomedical Sensors Market 2015 - Growth, Trends & Forecasts to 2020 2Portage's PPL will advance its lead candidate PPL-003 to an IND for dry eye disease and uveitis 2Portage's PPL will advance its lead candidate PPL-003 to an IND for dry eye disease and uveitis 3
Cached News: