HOME >> BIOLOGY >> NEWS
University Of Pittsburgh Scientist Discovers How A Novel Vitamin K Stops Cancer Cell Growth

PITTSBURGH, June 1 -- Scientists at the University of Pittsburgh have discovered how a novel form of vitamin K exerts its cancer-killing effects in primary liver cancers, which are notoriously resistant to chemotherapy. The research results, published in the May issue of The Journal of Biological Chemistry, describe an important new way to treat, and possibly prevent, cancer by triggering programmed cell death.

"Our finding is extremely important if we are to maximize the use of vitamin K compounds against cancer," noted Brian Carr, M.D., Ph.D., FRCP, professor of surgery in the Thomas E. Starzl Transplantation Institute and director of the Liver Cancer Center at the University of Pittsburgh Cancer Institute (UPCI). "Through our ongoing research, we now know that the vitamin K compounds not only can kill liver cancers, but also can destroy other types of cancer in tissue cultures, including breast cancer and melanoma. They do so by a quite novel growth-regulating mechanism."

"One of the attractive features of this unique compound is that it appears to stop cancer cell growth without producing toxicity. We now are testing this compound against cancers in rats, and given positive results, we hope to begin clinical trials of this agent within two years."

The Pitt research team found that a vitamin K analog, Compound 5 (Cpd 5), causes an imbalance in the normal activity of enzymes that control the addition or removal of small molecules called phosphate groups from selected proteins inside cells. Specifically, Cpd 5 blocks the activity of enzymes called protein-tyrosine phosphatases, which normally remove phosphate groups from selected proteins inside liver cancer cells. However, Cpd 5 does not interfere with another group of enzymes called protein tyrosine-kinases, which add phosphate groups to these same proteins. The result is an excess of what are called tyrosine phosphorylated proteins, which trigger a variet
'"/>

Contact: Lauren Ward
wardla@a1.isd.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
1-Jun-1998


Page: 1 2 3

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. University of Alberta researcher looks for clues to mysterious disease
3. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
4. Washington University in St. Louis leads group studying aging process
5. Tufts University establishes $4 million dollar tissue engineering resource center
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. As informatics grows, Indiana University helps set research agenda
8. University of Arizona licenses patent for natural fungicide
9. Washington University in St. Louis plays key role in sequencing moss genome
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. Clemson University spin-off uses corn to make plastics, provide cleaner air

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2017)... -- PMD Healthcare announces the release of its new ... (WMS), a remote, real-time lung health monitoring and management ... a Medical Device, Digital Health, and Chronic Care Management ... solutions that empower people to improve their healthcare and ... the first ever personal spirometer, Spiro PD, which was ...
(Date:3/7/2017)... , March 7, 2017 Brandwatch , the ... by The Prince,s Trust to uncover insights to support ... The Trust. The UK,s leading youth charity will be ... campaign results and get a better understanding of the topics and ... ...
(Date:3/2/2017)... -- Who risk to be deprived of its imprint ... https://www.reportbuyer.com/product/4313699/ WILL APPLE AND SAMSUNG CONFRONT ... sensors using capacitive technology represent a fast growing market, ... an increase of 360% of the number of fingerprint ... sensor market between 2014 and 2017 (source : N+1 ...
Breaking Biology News(10 mins):
(Date:3/20/2017)... , ... March 20, 2017 , ... ... HEPARIN calibration verification / linearity test kit has received US FDA 510(k) clearance ... VALIDATE® HEPARIN kit evaluates Heparin Anti-Xa activity in a human plasma matrix. ...
(Date:3/20/2017)... NEW YORK , March 20, 2017  Attorney Advertising ... behalf of purchasers of the BioAmber Inc. ("BioAmber" or the "Company") ... obtain additional information and assist the investigation by visiting the ... concerns whether BioAmber and certain of its officers and/or directors ... Act of 1934. ...
(Date:3/19/2017)...  Array BioPharma Inc. (Nasdaq: ARRY ) ... Food and Drug Administration,s (FDA) Division of Oncology Products ... for the treatment of NRAS -mutant melanoma, a ... This action was based on thorough discussions and communications ... approval, and followed the late cycle review meeting held ...
(Date:3/18/2017)... , March 17, 2017  A new study ... who historically have been considered ineligible for curative ... reirradiation using intensity-modulated proton therapy (IMPT) for lung ... patients were free from local recurrence at one ... ten patients experienced severe side effects. The study ...
Breaking Biology Technology:
Cached News: