HOME >> BIOLOGY >> NEWS
University of Alberta researcher looks for clues to mysterious disease

Few have heard of the degenerative, deadly disease called Ataxia-telangiectasia (A-T) but a University of Alberta researcher is hoping to provide clues to this mysterious disorder.

Dr. Shelagh Campbell, from the U of A's Department of Biological Sciences, is a basic researcher who studies how normal cell cycles are regulated, by analyzing genes that are responsible for repairing DNA damage that offer insights into human diseases like cancer and A-T.

A-T is a progressive, degenerative disease that affects a startling number of body systems. Children with A-T appear normal at birth but at around the age of two, some of the first signs--walking and balance is wobbly caused by ataxia or lack of muscle control--start appearing.

"Kids are often misdiagnosed with cerebral palsy but what distinguishes A-T is it gets worse," said Campbell. "Sadly, many of the people with A-T end up in wheelchairs and most die young (I think there is a fair range).

Soon after the onset of A-T, children lose their ability to write and speech becomes slow and slurred. Reading eventually becomes impossible because eye movements are too hard to control. Other features of the debilitating disease include mild diabetes, premature graying of the hair, difficulty swallowing causing choking and drooling and slowed growth. Children with A-T also tend to be more predisposed to developing cancer. Ironically, the disease carries with it sensitivity to radiation, which means A-T patients cannot tolerate the therapeutic radiation usually given to cancer patients.

That's where Campbell hopes to apply her work. Scientists already know that the A-T protein (ATM) is fundamental to repairing DNA damage so she and her research team are studying ATM mutants, which behave as cells do when they are damaged.

In a recent issue of the journal, "Current Biology," Campbell describes how they examined ATM mutants for signs of locomotor defects in mutant a
'"/>

Contact: Phoebe Dey
phoebe.dey@ualberta.ca
780-492-0437
University of Alberta
23-Sep-2004


Page: 1 2

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
3. Washington University in St. Louis leads group studying aging process
4. Tufts University establishes $4 million dollar tissue engineering resource center
5. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
6. As informatics grows, Indiana University helps set research agenda
7. University of Arizona licenses patent for natural fungicide
8. Washington University in St. Louis plays key role in sequencing moss genome
9. University of Pittsburgh receives $10 million grant for head and neck cancer
10. Clemson University spin-off uses corn to make plastics, provide cleaner air
11. Carnegie Mellon University hosts ACS-PRF summer school on green chemistry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/14/2018)... (PRWEB) , ... December 14, 2018 , ... ... patent number 9,703,929 entitled “Method and System for Microbiome-Derived Diagnostics and Therapeutics” by ... date of October 21, 2014. The patent is an invention by uBiome collaborators ...
(Date:12/13/2018)... ... December 12, 2018 , ... ... of regenerative cellular therapy, has announced the launch of Maxx-Cell, the world's most ... gold standard approach of aspirating a patients autologous bone marrow cells. Maxx™-Cell however ...
(Date:12/13/2018)... ... 2018 , ... Biocompare, the leading online information resource for ... to Know about Antibody Manufacturing” . This educational resource is the third documentary ... film is to educate scientists about antibody production, validation, and responsible sourcing. The ...
Breaking Biology News(10 mins):
(Date:1/20/2019)... ... January 17, 2019 , ... ... Partner announces the launch of a specialized automation technology, titled Automate 3D. Automate ... automatic generation of models and drawings to deliver to end-users, customers, and ERP ...
(Date:1/11/2019)... ... 11, 2019 , ... Drawing on over 22 years of software development expertise, ... EST will explore some of the key lessons that have driven customer satisfaction with ... multiple vendors, and find out how to ensure that you continue to be able ...
(Date:1/8/2019)... ... January 08, 2019 , ... The American Society of ... were named by a selection committee made up of industry leaders identified by the ... Development grants are mentored awards created to support ASGCT members designing transformative pilot studies ...
(Date:1/4/2019)... , ... January 03, 2019 , ... ... forefront of oncolytic virus-based immunotherapies for cancer, today announced the founding of a ... receive critical input and guidance from key leaders in the Immuno-Oncology field. The ...
Breaking Biology Technology:
Cached News: