HOME >> BIOLOGY >> NEWS
University of Chicago scientists pinpoint cellular cause of SIDS

University of Chicago researchers may have found a crucial clue to understanding and ultimately eliminating sudden infant death syndrome, the leading cause of post-neonatal mortality in the United States. Approximately 3,000 infants die each year from the disorder, according to the Centers for Disease Control and Prevention.

In the July 8, 2004, issue of the journal Neuron, the researchers describe the specific group of neurons that are responsible for gasping and what happens to these cells when they are deprived of oxygen. Since gasping resets the normal breathing pattern for babies, the scientists suspect that a malfunction in these respiratory pacemakers is the cellular mechanism that leads to SIDS.

"This paper sets the groundwork for everything that has to do with breathing," says lead author Jan-Marino Ramirez, an associate professor of organismal biology and anatomy. "We've now defined the players in the system."

The study follows a paper published in Nature four years ago in which Ramirez and colleagues showed that the same network of respiratory cells in the brainstem controls different forms of breathing: the sigh, the gasp and normal rhythm.

Shortly after the groundbreaking paper, scientists overturned conventional theory that pacemaker neurons drive the entire network of cells. Researchers found that riluzole, a drug that blocks the cell's sodium channel, could silence pacemaker neurons yet the rhythm of the network remained active.

But, according to Ramirez, riluzole didn't disable all of the pacemakers, which is why the rhythm continued. He found that there are two groups of pacemaker neurons, one of which does not depend on sodium channels to operate, but on calcium channels. Only four out of 172 pacemaker cells were not affected by riluzole.

"You have to have a perfect recording in order to get those cells," Ramirez says. "It's not that these neurons are more powerful, just more elusive."

To
'"/>

Contact: Catherine Gianaro
catherine.gianaro@uchospitals.edu
773-702-6241
University of Chicago Medical Center
7-Jul-2004


Page: 1 2 3

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. University of Alberta researcher looks for clues to mysterious disease
3. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
4. Washington University in St. Louis leads group studying aging process
5. Tufts University establishes $4 million dollar tissue engineering resource center
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. As informatics grows, Indiana University helps set research agenda
8. University of Arizona licenses patent for natural fungicide
9. Washington University in St. Louis plays key role in sequencing moss genome
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. Clemson University spin-off uses corn to make plastics, provide cleaner air

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/12/2019)... ... 11, 2019 , ... Neal O’Farrell is one of the first generation of ... executive director of the consumer advocacy non-profit the Identity Theft Council as well as ... the Federal Communications Commission’s Cybersecurity Roundtable and is currently a fellow of the EP3 ...
(Date:4/9/2019)... ... April 09, 2019 , ... The McLeod Center for Cancer Treatment and ... rigorous and voluntary audit conducted by an independent, third-party panel of experts in radiation ... in the United States, McLeod is the only such cancer center in South Carolina. ...
(Date:4/4/2019)... ... April 02, 2019 , ... The live session ... into the connectivity between product risk management (ISO 14971) and the clinical risk ... process. , With increasing global regulation and reimbursement challenges faced by medical device ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... ... March 19, 2019 , ... Konica Minolta Precision Medicine, Inc. ... of their inaugural Scientific Advisory Board. , Founded in late 2018, ... individual variability in genes, environment, and lifestyle to more accurately predict, detect, treat ...
(Date:3/18/2019)... ... March 18, 2019 , ... For more than 15 years, USDM ... allow life science companies to easily comply with FDA 21 CFR Part 11 and ... a managed service delivering end-to-end GxP compliance from vendor audit through ongoing validation maintenance, ...
(Date:3/14/2019)... ... March 14, 2019 , ... Open registration for the ... Full Spectrum of Case Management,” continues as CMSA makes plans to host the ... only case management industry conference serving the educational and networking needs of case ...
(Date:3/14/2019)... ... March 14, 2019 , ... ... standard solution for preclinical research organizations. It is a low code, GDPR/21 ... systems and facilities, innovative technology-driven automated data capture and seamless data and ...
Breaking Biology Technology:
Cached News: