HOME >> BIOLOGY >> NEWS
University of Florida researchers test drug from 'transgenic sheep' in study at Shands at UF teaching hospital

GAINESVILLE---In an early test of breakthrough technology, University of Florida researchers have begun the first pilot study to determine whether the milk of genetically modified sheep can help people prone to life-threatening lung problems caused by a specific protein deficiency.

PPL Therapeutics of Edinburgh, Scotland, the lead company involved in the development of Dolly the cloned sheep, uses recombinant DNA technology -- in which a gene from one organism is inserted into the DNA of another -- to create "transgenic sheep" that produce the human protein alpha-1-antitrypsin, or AAT. The protein is then extracted from the milk.

Within the past 10 days, six patients whose bodies manufacture inadequate amounts of AAT, leaving them vulnerable to emphysema, have begun receiving inhaled doses of it at Shands at UF teaching hospital.

If the technique proves successful in this and larger controlled trials, a vast new source of AAT, at a sharply reduced price, potentially would be available to treat the estimated 100,000 Americans who have a deficiency of the protective protein that helps to keep lung inflammation and damage in check.

Such a new supply is critical: Currently, only a limited amount is available through blood plasma donations, so many eligible candidates must do without the therapy, which is delivered intravenously at an estimated cost of $60,000 to $80,000 annually per patient.

"I have great hopes that this will be the cornerstone therapy for this disease," said Dr. Mark Brantly, lead investigator for the study and a professor of medicine, and molecular genetics and microbiology at UF's College of Medicine.

"It could be the major 'bridge' treatment before we advance to gene therapy for this disorder," said Brantly, who also is affiliated with UF's new Genetics Institute, which is exploring such possibilities with grant support from the National Institutes of Health.

"One of the primary reasons for creating the Genetics Insti
'"/>

Contact: Vicki White
vickiwhite@xtalwind.net
352-344-2738
University of Florida
30-Aug-1999


Page: 1 2 3

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. University of Alberta researcher looks for clues to mysterious disease
3. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
4. Washington University in St. Louis leads group studying aging process
5. Tufts University establishes $4 million dollar tissue engineering resource center
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. As informatics grows, Indiana University helps set research agenda
8. University of Arizona licenses patent for natural fungicide
9. Washington University in St. Louis plays key role in sequencing moss genome
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. Clemson University spin-off uses corn to make plastics, provide cleaner air

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... 2017 UBM,s Advanced Design and Manufacturing event ... emerging and evolving technology through its 3D Printing and ... alongside the expo portion of the event and feature ... focused on trending topics within 3D printing and smart ... event will take place June 13-15, 2017 at the Jacob ...
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
(Date:4/5/2017)... -- Today HYPR Corp. , leading innovator in ... the HYPR platform is officially FIDO® Certified . ... that empowers biometric authentication across Fortune 500 enterprises and ... 15 million users across the financial services industry, however ... suites and physical access represent a growing portion of ...
Breaking Biology News(10 mins):
(Date:10/7/2017)... Arizona (PRWEB) , ... October ... ... 15 years’ experience providing advanced instruments and applications consulting for microscopy and ... in-house expertise in application consulting, Nanoscience Analytical offers a broad range of ...
(Date:10/7/2017)... Oct. 6, 2017  The 2017 Nobel Prize ... scientists, Jacques Dubochet, Joachim Frank and ... cryo-electron microscopy (cryo-EM) have helped to ... structural biology community. The winners worked with systems ... routinely produce highly resolved, three-dimensional images of protein ...
(Date:10/6/2017)... ... 2017 , ... On Tuesday, October 24th, ABC² (Accelerate Brain ... adaptive clinical trial for glioblastoma (GBM). The featured speaker will be Dr. Brian ... to the public, but registration is required. , WHAT: ABC² Brain Cancer ...
(Date:10/5/2017)... ... October 05, 2017 , ... Understanding the microbiome, the millions of bacteria ... Gut Love: You Are My Future, the newest exhibit on display at the University ... the human condition through the lens of the gut microbiome. , Gut Love ...
Breaking Biology Technology:
Cached News: