HOME >> BIOLOGY >> NEWS
University of Kentucky Neuroscientist Develops Unique Device For Treatment Of Brain Tumors

LEXINGTON, Ky., Aug. 3, 1998 -- A device patented by a University of Kentucky Chandler Medical Center neuroscientist has shown promising early results in patient survival times in treatment of malignant gliomas, the most common type of brain tumor in adults.

The device, called Serodur, delivers chemotherapy to a non-operable brain tumor through a small plastic tube that runs directly into the center of the tumor. The tube is connected to a small plastic bubble, called an Ommaya reservoir, that is implanted under the patient's scalp. A cellophane-like permeable membrane in the bubble regulates the flow of the cancer-fighting drug into the tumor.

"By using Serodur, we're able to give small total doses that produce large concentrations of anticancer drugs in the brain without exposing the patient's body to the systemic effects of the medicine," said Roy Patchell, M.D., University of Kentucky Chandler Medical Center neuroscientist and inventor of the device. "Our studies are preliminary, but we've seen some long-term survivors, which is unusual for this kind of cancer."

More than half of the patients who contract a malignant glioma live less than one year, despite aggressive treatment with surgery, radiation therapy and intravenous chemotherapy, Patchell said. Intravenous chemotherapy often causes severe toxicity, so patients cannot be given enough of the drug to have effective results. In addition, many anticancer drugs cannot cross the blood-brain barrier in concentrations high enough to kill the tumor. When drugs do get into the brain, they only remain active for a few hours -- not enough time to destroy the tumor.

By running the tube directly into patients' tumors, Patchell has been able to eliminate side effects normally associated with chemotherapy, such as nausea, hair loss and fatigue. The survival rates of patients who have tried Serodur is even more impressive.

"Most patients with recurr
'"/>

Contact: Kim Cumbie
krcumb0@pop.uky.edu
(606) 323-6363
University of Kentucky Medical Center
3-Aug-1998


Page: 1 2

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. University of Alberta researcher looks for clues to mysterious disease
3. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
4. Washington University in St. Louis leads group studying aging process
5. Tufts University establishes $4 million dollar tissue engineering resource center
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. As informatics grows, Indiana University helps set research agenda
8. University of Arizona licenses patent for natural fungicide
9. Washington University in St. Louis plays key role in sequencing moss genome
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. Clemson University spin-off uses corn to make plastics, provide cleaner air

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... MELBOURNE, Florida , April 17, 2017 ... security technology company, announces the filing of its 2016 Annual Report ... Securities and Exchange Commission. ... Report on Form 10-K is available in the Investor Relations section ... well as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... , April 11, 2017 No two ... researchers at the New York University Tandon School ... Engineering have found that partial similarities between prints ... used in mobile phones and other electronic devices ... The vulnerability lies in the fact that ...
(Date:4/5/2017)... 4, 2017 KEY FINDINGS The ... at a CAGR of 25.76% during the forecast period ... primary factor for the growth of the stem cell ... MARKET INSIGHTS The global stem cell market ... and geography. The stem cell market of the product ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 2017 , ... A new study published in Fertility and ... in vitro fertilization (IVF) transfer cycles. The multi-center matched cohort study ... comparing the results from the fresh and frozen transfer cohorts, the authors of ...
(Date:10/10/2017)... CA (PRWEB) , ... October ... ... a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today ... of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration ...
(Date:10/10/2017)... 2017 International research firm Parks Associates announced today ... the TMA 2017 Annual Meeting , October 11 in ... home security market and how smart safety and security products impact the ... Parks Associates: Smart Home Devices: ... "The residential security market has experienced ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program ... honoring scientists who have made outstanding contributions to analytical chemistry and ... 2018, the world’s leading conference and exposition for laboratory science, which will be ...
Breaking Biology Technology:
Cached News: