HOME >> BIOLOGY >> NEWS
University of Maryland research reveals true target of calcium channel blockers

Researchers at the University of Maryland School of Medicine have discovered that calcium channel blockers--widely used to treat heart problems and high blood pressure--work differently than previously thought. Their findings, published in the December issue of the American Journal of Physiology, may open the door to a different approach to treatment, with new, more effective medications that have a more precise therapeutic focus than current treatments.

The researchers found that calcium channel blockers primarily affect a group of cellular calcium channels in small arteries called "store-operated" channels. Prior to this discovery, scientists thought the blockers selectively affected what are known as "voltage-gated" channels.

"Our research has significant implications for the future treatment of heart disease and hypertension," says the study's senior author, Mordecai P. Blaustein, M.D., professor and chair of the Department of Physiology at the University of Maryland School of Medicine. "Armed with this knowledge, it should be possible to look for a new class of drugs that would cause fewer side effects."

"There are some observations that are a leap forward, not merely an incremental step," says C. William Balke, M.D., professor of medicine and physiology and head of the Division of Cardiology at the University of Maryland School of Medicine and the University of Maryland Medical Center. "This could easily be a leap. It certainly could change our paradigm for the treatment of hypertension," adds Dr. Balke.

Calcium, a mineral, is essential for the functioning of a number of systems in the body, including the pumping action of the heart and the contraction and relaxation of the smooth muscles that line blood vessel walls to regulate blood pressure. Too much tone or constriction can cause small arteries to narrow and increase their resistance to blood flow, leading to high blood pressure and forcing the heart to work harder.
'"/>

Contact: Larry Roberts
lroberts@som.umaryland.edu
410-706-7590
University of Maryland Medical Center
4-Dec-2002


Page: 1 2 3

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. University of Alberta researcher looks for clues to mysterious disease
3. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
4. Washington University in St. Louis leads group studying aging process
5. Tufts University establishes $4 million dollar tissue engineering resource center
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. As informatics grows, Indiana University helps set research agenda
8. University of Arizona licenses patent for natural fungicide
9. Washington University in St. Louis plays key role in sequencing moss genome
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. Clemson University spin-off uses corn to make plastics, provide cleaner air

Post Your Comments:
(Date:8/26/2014)... at the University of Illinois at Urbana-Champaign have ... paving the way for power-on-a-chip applications. , ... scale that amplify light and produce ultra-narrowband spectral ... electrical and computer engineering (ECE) at Illinois. "These ... power on a chip containing both electronic and ...
(Date:8/26/2014)... recommended investing in dog owner education and facilities as a ... in both people and their pets. , In a review ... access to dog-friendly walking environments and better education about dogs, ... take more exercise with their pets. , It is estimated ... a walk. In the UK, almost a quarter of households ...
(Date:8/25/2014)... the first U.S. outbreaks of the H1N1 virus swept ... people. A university math and biology professor has used ... gain insight into how only a few infected people ... community., The fall 2009 semester hadn,t even started when ... and Wellness Services clinic11 one day, and just two ...
Breaking Biology News(10 mins):Symphony of nanoplasmonic and optical resonators produces laser-like light emission 2Education and dog-friendly neighbourhoods could tackle obesity 2WSU flu outbreak provides rare study material 2WSU flu outbreak provides rare study material 3
(Date:8/27/2014)... According to the 2013 Raw Material ... look and feel of markets for raw materials and ... will push for more branded, science-backed products.” , Natural ... market growth in the last decade as consumers increasingly ... cosmetics to fit a more ‘wellness’ lifestyle approach. ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Budding ... Cleveland's University School participated in the ... Western Reserve University’s School of Medicine . ... with an unparalleled professional experience in the sciences ... of Medicine faculty and students for both academic ...
(Date:8/26/2014)... and Bellingham, WA (PRWEB) August 26, 2014 ... engineering, visions for next-generation wearable technology, and inspiration ... numerous highlights at this year’s brighter, busier ... Diego, California, Convention Center. More than 4,400 international ... attended conferences, courses, an exhibition, and industry sessions ...
(Date:8/26/2014)... team of engineers from Singapore has successfully piloted ... for satellite communications. , With the weight of ... constructing a lightweight, low power-consuming, wireless communication system ... has always been a challenge for system designers. ... Centre of Nanyang Technological University in Singapore launched ...
Breaking Biology Technology:Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 3Students at Cleveland's University School Conduct Biomedical Research at Case Western Reserve University’s School of Medicine 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4ZigBee in the Sky 2
Cached News: