HOME >> BIOLOGY >> NEWS
University of Pittsburgh discovers gene mutation responsible for hereditary gingival fibromatosis

PITTSBURGH, April 1 A mutation in a gene that signals for cellular growth is responsible for the rare hereditary disease that causes the gums to grow over the teeth. The results, published in the April American Journal of Human Genetics, may help researchers explain the mechanisms by which such gingival overgrowth occurs.

An international team of researchers from the United States and Brazil discovered that a mutation in the Son of sevenless-1 (SOS1) gene causes hereditary gingival fibromatosis (HGF) type one, a rare form of gingival overgrowth. The team, led by Thomas Hart, D.D.S., Ph.D., associate professor of oral pathology and medicine, at the University of Pittsburgh School of Dental Medicine, studied a large multi-generational Brazilian family with high incidence of HGF.

From the information gathered from this family, they were able to determine the structure of the SOS1 gene. The gene codes for a protein that activates the ras pathway, which signals cell growth. When the gene is not mutated it is involved in the growth of normal, healthy gums. When the gene is mutated in the fashion discovered by Hart and his colleagues, it results in HGF.

By understanding this gene and the mutation, we have the potential to understand what causes normal gingival growth and abnormal gingival overgrowth. We are now looking at the therapeutic potenital of manipulating this pathway, said Dr. Hart. Not only does this create the potential for new therapies to treat HGF, but also new avenues for investigation into common dental problems like periodontal disease and receding gums.

Currently, the only available treatment for HGF includes cutting away the gingival overgrowth and trying to regrow the tissue between the teeth through grafting, a process that is both difficult and painful. By understanding the genetic cause of the disease, researchers say they can now start investigating new therapies, including tissue engineering to treat the disease.
'"/>

Contact: Jocelyn Uhl
412-624-2607
University of Pittsburgh Medical Center
1-Apr-2002


Page: 1 2

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. University of Alberta researcher looks for clues to mysterious disease
3. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
4. Washington University in St. Louis leads group studying aging process
5. Tufts University establishes $4 million dollar tissue engineering resource center
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. As informatics grows, Indiana University helps set research agenda
8. University of Arizona licenses patent for natural fungicide
9. Washington University in St. Louis plays key role in sequencing moss genome
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. Clemson University spin-off uses corn to make plastics, provide cleaner air

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/22/2020)... ... July 21, 2020 , ... ... innovation in technology and compliance, announces a new solution to manage regulated workloads ... every layer of their technology stack complies with FDA and global regulations. USDM's ...
(Date:7/4/2020)... PHOENIX (PRWEB) , ... July 03, 2020 , ... ... is proud to earn outstanding recognition and multiple awards for not only the ... the ABM portfolio, SoME® Skincare and Vivace® Microneedle RF. All the brands built ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... software solutions for biopharmaceutical R&D, today announced that it has entered into ... full-length multispecific antibodies (Multiclonics®), to support their translational and clinical research strategy ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... ... June 29, 2020 , ... The Interlocal ... contracts to its membership, recently named BioFit Engineered Products an Awarded ... to purchase ergonomic seating, cafeteria tables, book trucks and carts at discounted pricing ...
(Date:6/28/2020)... ... 25, 2020 , ... The Indoor Lab, a leading provider of sensor solutions ... all types to ensure cleanliness, distancing and occupancy with its patent pending WipeAway™ technology ... business will provide a health performance index system that scores all aspects of compliance ...
(Date:6/28/2020)... HILL, Conn. (PRWEB) , ... June 25, 2020 ... ... company formed to advance photodynamic therapy for treating cancer, today announced the company ... New York (“Roswell Park”). The agreement provides Lumeda globally exclusive rights to ...
(Date:6/23/2020)... ... 23, 2020 , ... Kerafast Inc. , developers of ... the availability of the Delta-G-VSV Pseudotyping System for coronavirus research applications. The system, ... SARS-CoV-2 viral entry and COVID-19 vaccine effectiveness at just biosafety level 2 (BSL-2) ...
Breaking Biology Technology:
Cached News: