University of Pittsburgh discovery of HIV 'shedding' patterns and viral site will change direction of research on AIDS vaccines and treatments

PITTSBURGH, Jan. 30 -- AIDS researchers at the University of Pittsburgh have found that viral secretion in HIV-positive men follows one of three patterns, which are in turn related to different sources of HIV in the body. This discovery, which has important implications for research on vaccines and retroviral therapies, was presented on Sunday, Jan. 30, in a poster session at the Seventh Conference on Retroviruses and Opportunistic Infections in San Francisco.

"For the first time, we see that some HIV-positive men continuously produce, or shed, the virus, and that in this case the virus originates in the blood," said Principal Investigator Phalguni Gupta, Ph.D., professor, department of infectious diseases and microbiology at the University of Pittsburgh's Graduate School of Public Health. "Other men shed intermittently, and in them the virus is produced in a genital organ, probably the prostate." Another 28 percent of the participants were found to be non-shedders, meaning that virus was not detected in the semen but could be in the blood. While they are antibody-positive, non-shedders are less likely to infect their partners.

Previous research has shown that some men have the same strain of HIV in their blood and semen, while others exhibit differing strains. "Interestingly, we now see that those with the same strains in blood and semen are continuous shedders, while those with distinct virus populations are intermittent shedders," Dr. Gupta explained.

Investigators studied 18 HIV-infected men from the Pittsburgh site of the national Multicenter AIDS Cohort Study, known locally as the Pitt Men's Study. Participants were asymptomatic and not receiving any potent antiretroviral therapy, such as protease inhibitors. Paired blood and semen samples were collected at weekly intervals for 10 weeks and tested for viral load. HIV was detected at all 10 visits in the semen of five subjects (28 percent), constituting

Contact: Kathryn Duda
University of Pittsburgh Medical Center

Page: 1 2 3

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. University of Alberta researcher looks for clues to mysterious disease
3. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
4. Washington University in St. Louis leads group studying aging process
5. Tufts University establishes $4 million dollar tissue engineering resource center
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. As informatics grows, Indiana University helps set research agenda
8. University of Arizona licenses patent for natural fungicide
9. Washington University in St. Louis plays key role in sequencing moss genome
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. Clemson University spin-off uses corn to make plastics, provide cleaner air

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: