University of Pittsburgh researchers identify subtype of cell that promotes organ transplant acceptance

CHICAGO, May 15 -- In one of the few studies of its kind, researchers from the University of Pittsburgh's Thomas E. Starzl Transplantation Institute have found that a subtype of dendritic cell plays a key role in preventing organ rejection and may be associated with transplant tolerance, the long-term survival of a transplanted organ without the need for immunosuppressant drugs.

Researchers will now be looking to see if the same cells are present in liver and kidney transplant recipients who have been successfully weaned off immunosuppression, patients who are essentially tolerant of their organs.

The findings are significant because dendritic cells, a rare type of white blood cell that is present in all tissues, have been thought only to be involved in prompting the rejection process, reported Peta J. O'Connell, Ph.D., at Transplant 2001, the joint meeting of the American Society of Transplantation (AST) and the American Society of Transplant Surgeons.

Dendritic cells are known for their ability to identify and present antigens, or foreign substances, to other immune system cells that are programmed to destroy the antigen. But according to Dr. O'Connell, some dendritic cells apparently regulate the immune response, determining that a frontline attack by T cells can be unwarranted.

Dr. O'Connell, a visiting research instructor working with Angus W. Thomson, Ph.D., D.Sc., reported that a pre-transplant infusion of lymphoid dendritic cell subtypes derived from tissue such as the spleen, allowed for prolonged survival in a mouse heart transplant model, even without the use of drugs to control rejection. In contrast, myeloid dendritic cells accelerated the rejection response.

"The lymphoid-derived dendritic cells somehow disarm immune system T cells from doing their part to attack the donor organ possibly by causing either their death or limiting their proliferation," explained Dr. O'Connell, who received an AST Young Investigator's Award for her wor

Contact: Lisa Rossi
University of Pittsburgh Medical Center

Page: 1 2

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. University of Alberta researcher looks for clues to mysterious disease
3. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
4. Washington University in St. Louis leads group studying aging process
5. Tufts University establishes $4 million dollar tissue engineering resource center
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. As informatics grows, Indiana University helps set research agenda
8. University of Arizona licenses patent for natural fungicide
9. Washington University in St. Louis plays key role in sequencing moss genome
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. Clemson University spin-off uses corn to make plastics, provide cleaner air

Post Your Comments:

(Date:5/21/2020)... CARY, N.C. (PRWEB) , ... ... ... Solutions , the leading software-as-a-service (SaaS) provider of operations management solutions, today ... new BioMed module provides a cloud-based platform for connecting the people and ...
(Date:5/14/2020)... ... May 12, 2020 , ... ... helps Life Science Manufacturers accurately and easily project contracted liabilities with payers, ... Gross-to-Net models by projecting discounts/rebates to Commercial and Government entities, Copay and ...
(Date:5/6/2020)... ... May 06, 2020 , ... ... http://www.brevitest.com ) will become the latest out-of-state company to partner with ... Harbor. , Brevitest has developed a point-of-care analyzer capable of accurately performing ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... ... May 15, 2020 , ... Sentien Biotechnologies, Inc., a ... Richard Ganz as Executive Chairman. Mr. Ganz will continue to lead Sentien’s Board ... as work closely with CEO Brian Miller and Sentien’s management team. , ...
(Date:5/9/2020)... ... , ... Worldwide Business with kathy ireland® will be LIVE ... 2020 and Wednesday, May 13, 2020 at 8:00pm ET / PT – prime ... from Techolution and Bravado Pharmaceuticals . , As leaders in ...
(Date:4/26/2020)... ... April 23, 2020 , ... Indegene Omnipresence, Inc. announced the ... and services for use on Microsoft Azure. The customer experience management (CXM) technology ... for a built-for-purpose customer engagement capability to use in their commercial or medical ...
(Date:4/18/2020)... ... April 17, 2020 , ... ... Small Business Innovation Research (SBIR) program to support the expansion of its digital ... the NSF, which conducts a rigorous merit-based review process, adds to NeuroFlow’s ...
Breaking Biology Technology:
Cached News: