KSHV is the cause of Kaposi's sarcoma, a common cancer among AIDS patients, and also is linked to other immune disorders including a type of B-cell lymphoma and Castleman's disease, a noncancerous but severe disorder characterized by enlargement of the lymph nodes.
Dr. Chang will share the $125,000 Marks Prize with two other scientists under the age of 45 who have made significant contributions to the basic understanding and treatment of cancer.
"Yuan Chang's discovery of KSHV was a seminal breakthrough that has enabled all subsequent understanding of how the virus causes disease, as well as the diagnosis and potential treatment of KSHV infection," said Elliott D. Kieff, M.D., Ph.D., professor of microbiology and molecular genetics at Harvard Medical School. "Her basic and clinical research has transformed our understanding of the most common malignancy in people infected with HIV."
Dr. Chang, 43, co-discovered KSHV, also known as human herpesvirus 8, along with her husband, Patrick Moore, M.D., M.P.H., professor of molecular genetics and biochemistry at the University of Pittsburgh and director of the molecular biology program at the University of Pittsburgh Cancer Institute. Prior to their discovery, Kaposi's sarcoma was believed to be caused by an infectious agent, but the cause of the disease remained unknown.
Since discovering KSHV in 1994, Dr. Chang has continued to study the biology of the virus to understand the basis for its ability to cause cancer. In 1996, she and her colleagues published the DNA sequence of KSHV, revealing that the virus has pirated several cellular
Contact: Clare Collins
University of Pittsburgh Medical Center