HOME >> BIOLOGY >> NEWS
University of Rochester scientists test new method to attack cancer

NOTE: This release has been updated since its original posting.

Scientists have used a technique called RNA interference to impair cancer cells' ability to produce a key enzyme called telomerase. The enzyme, present in most major types of cancer cells, gives cells the lethal ability to divide rampantly without dying. The laboratory experiments create an opportunity for researchers who are focusing on telomerase in a bid to develop a drug like none ever developed - one capable of killing 85 percent of cancers

The research, led by Peter T. Rowley, M.D., of the University of Rochester Medical Center, is being presented today at the annual meeting of the American Association for Cancer Research in Washington, D.C.

The enzyme telomerase produces telomeres, located at the ends of each chromosome, which protect the ends of chromosomes as cells divide. In a normal cell, the telomeres shorten each time the cell divides. After a cell divides 50 to 100 times, the telomeres shorten so much that they can no longer protect the chromosome, and the cell eventually dies.

Scientists believe that such cell death is normal, even healthy. But as a healthy cell turns cancerous, a genetic mutation triggers the production of telomerase, which restores the telomeres to normal length. The restored telomeres enable the cell to divide, unchecked, thousands of times instead of the usual 50 to 100. Over time, a few cancer cells can multiply into a golf-ball-sized tumor or spread to other parts of the body.

Since researchers discovered the important role telomerase plays in most cancers in the mid-1990s, much attention has been focused on finding a way to attack them. Several methods are in various stages of development.

The University of Rochester team used RNA interference to disrupt the production of telomerase in various cancer cells including colon, skin, cervical, and lung cancer. They crafted tiny snippets of double-
'"/>

Contact: Christopher DiFrancesco
chris_difrancesco@urmc.rochester.edu
585-273-4790
University of Rochester Medical Center
14-Jul-2003


Page: 1 2

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. University of Alberta researcher looks for clues to mysterious disease
3. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
4. Washington University in St. Louis leads group studying aging process
5. Tufts University establishes $4 million dollar tissue engineering resource center
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. As informatics grows, Indiana University helps set research agenda
8. University of Arizona licenses patent for natural fungicide
9. Washington University in St. Louis plays key role in sequencing moss genome
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. Clemson University spin-off uses corn to make plastics, provide cleaner air

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
(Date:4/13/2017)... 2017 UBM,s Advanced Design and Manufacturing event ... emerging and evolving technology through its 3D Printing and ... alongside the expo portion of the event and feature ... focused on trending topics within 3D printing and smart ... event will take place June 13-15, 2017 at the Jacob ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
Breaking Biology News(10 mins):
(Date:7/14/2017)... ... July 14, 2017 , ... Diagenode and PreOmics ... to clean peptides for mass spectrometry (MS) analysis combining the PreOmics in-StageTip Kit ... Kit is based on proprietary technology that contains optimized buffer systems permitting ultrafast ...
(Date:7/13/2017)... ... July 13, 2017 , ... ... spectrophotometer calibration standards. Blast forward seven years and now they are home ... holmium oxide for wavelength accuracy, and resolution testing. , One ...
(Date:7/13/2017)... ... ... Microscan , the number-one brand of embedded clinical barcode readers and ... MicroHAWK platform for barcode reading and machine vision, LVS label verification, and ... taking place on August 1–3 in San Diego, CA. , MicroHAWK barcode readers ...
(Date:7/12/2017)... (PRWEB) , ... July 12, 2017 , ... ... provider is pleased to announce the release of FreezerPro® version 7.2. , Hundreds ... aliquoting, and query sample information. For ten years, RURO has been at the ...
Breaking Biology Technology:
Cached News: