HOME >> BIOLOGY >> NEWS
University of Rochester scientists test new method to attack cancer

NOTE: This release has been updated since its original posting.

Scientists have used a technique called RNA interference to impair cancer cells' ability to produce a key enzyme called telomerase. The enzyme, present in most major types of cancer cells, gives cells the lethal ability to divide rampantly without dying. The laboratory experiments create an opportunity for researchers who are focusing on telomerase in a bid to develop a drug like none ever developed - one capable of killing 85 percent of cancers

The research, led by Peter T. Rowley, M.D., of the University of Rochester Medical Center, is being presented today at the annual meeting of the American Association for Cancer Research in Washington, D.C.

The enzyme telomerase produces telomeres, located at the ends of each chromosome, which protect the ends of chromosomes as cells divide. In a normal cell, the telomeres shorten each time the cell divides. After a cell divides 50 to 100 times, the telomeres shorten so much that they can no longer protect the chromosome, and the cell eventually dies.

Scientists believe that such cell death is normal, even healthy. But as a healthy cell turns cancerous, a genetic mutation triggers the production of telomerase, which restores the telomeres to normal length. The restored telomeres enable the cell to divide, unchecked, thousands of times instead of the usual 50 to 100. Over time, a few cancer cells can multiply into a golf-ball-sized tumor or spread to other parts of the body.

Since researchers discovered the important role telomerase plays in most cancers in the mid-1990s, much attention has been focused on finding a way to attack them. Several methods are in various stages of development.

The University of Rochester team used RNA interference to disrupt the production of telomerase in various cancer cells including colon, skin, cervical, and lung cancer. They crafted tiny snippets of double-
'"/>

Contact: Christopher DiFrancesco
chris_difrancesco@urmc.rochester.edu
585-273-4790
University of Rochester Medical Center
14-Jul-2003


Page: 1 2

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. University of Alberta researcher looks for clues to mysterious disease
3. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
4. Washington University in St. Louis leads group studying aging process
5. Tufts University establishes $4 million dollar tissue engineering resource center
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. As informatics grows, Indiana University helps set research agenda
8. University of Arizona licenses patent for natural fungicide
9. Washington University in St. Louis plays key role in sequencing moss genome
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. Clemson University spin-off uses corn to make plastics, provide cleaner air

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/12/2020)... ... August 12, 2020 , ... Mosio ... are ideal for public health agencies of all sizes. With a focus on ... at-risk individuals find appropriate health care, Mosio helps public health departments automate communications ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... II contract awarded by the Joint Science & Technology Office—Chemical and Biological Defense ... to develop, optimize, and scale-up a highly efficient mammalian cell culture-based bioprocess suitable ...
(Date:7/10/2020)... FALLS CHURCH, Va. (PRWEB) , ... July 08, ... ... , The Latest on Cell and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, ... product may need a comparability study, but what is the most effective way ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... Mass. (PRWEB) , ... July 29, 2020 , ... ... wire that can combine up to three different materials for use with CRM, ... combine up to three materials to meet specific design requirements, performance, and cost ...
(Date:7/31/2020)... , ... July 30, 2020 ... ... cloud-based software for the life sciences industry, today announced the release of ... designed specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
(Date:7/18/2020)... ... July 16, 2020 , ... Medial EarlySign , ... and prevention of high-burden diseases, and Centric Consulting, a business and technology consulting ... utilize existing data in order to identify and prioritize patients for care. , ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most research using ... suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. ... has been using the zebrafish model to investigate the causes of leukaemia and ...
Breaking Biology Technology:
Cached News: