HOME >> BIOLOGY >> NEWS
University of Washington partners with Advanced Tissue Sciences and others in $10 million grant to 'grow' human heart tissue

Bioengineering researchers at the University of Washington will lead a multi-million-dollar effort to grow functional human heart tissue, an undertaking that could lead to tissue-engineered replacement hearts and set in place the technology to grow other major organs in the laboratory.

The project, funded by a grant from the National Institutes of Health for $10 million over five years, will initially focus on culturing thick "patches" of cardiac muscle that could be grafted onto damaged hearts to improve their efficiency.

The next step will be engineering a "ventricular tube," a cylinder of rolled cardiac muscle with valves that could assist a weakened heart with pumping. Then a full ventricle will be attempted. Eventually, researchers hope their work will enable scientists to grow a fully functional human heart.

In growing such devices, and eventually an entire heart, researchers will begin with a "scaffolding," or porous structure upon which cardiac cells can gain a foothold. The scaffolding is seeded with cells then placed in a bioreactor, which maintains a steady temperature conducive to development and provides cells with the nutrients they need to grow and reproduce. Advanced Tissue Sciences' patented technology will play a key role in the partnership's efforts.

Initially, researchers will be working with skeletal muscle cells, or myocytes, as well as with cardiac cells. Stem cells, or cells that have the ability to develop into specialized cells such as cardiac cells, provide another important key. The use of stem cells on a scaffold is largely unexplored and will be a major thrust of the project. Such cells could give scientists a virtually never-ending supply of cardiac cells for tissue engineering. And they may even hold clues to solving the problem of rejection by using the patient's own cells to grow new organs.

The effort represents a public-private collaboration led by the University of Washington. Partners, who will s
'"/>

Contact: Rob Harrill
rharrill@u.washington.edu
206-543-2580
University of Washington
21-May-2000


Page: 1 2 3 4

Related biology news :

1. Indiana University, EPA to study airborne PCBs
2. University of Alberta researcher looks for clues to mysterious disease
3. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
4. Washington University in St. Louis leads group studying aging process
5. Tufts University establishes $4 million dollar tissue engineering resource center
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. As informatics grows, Indiana University helps set research agenda
8. University of Arizona licenses patent for natural fungicide
9. Washington University in St. Louis plays key role in sequencing moss genome
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. Clemson University spin-off uses corn to make plastics, provide cleaner air

Post Your Comments:
(Date:4/17/2014)... Orange, NJ. April 16, 2014. Kessler Foundation has ... $1.8 million from the Department of Defense Spinal ... is principal investigator for the randomized, double-blinded, controlled, ... improve bone and muscle strength after spinal cord ... Performance & Engineering Research at Kessler Foundation. Two ...
(Date:4/17/2014)... N.M. A credit-card-sized anthrax detection cartridge developed at ... business makes testing safer, easier, faster and cheaper. ... anthrax, is commonly found in soils all over the ... in both humans and animals. The bacteria can survive ... B. anthracis may occur through skin contact, ...
(Date:4/17/2014)... Kansas State University engineer has developed a patented ... improvised explosive devices. The same technique could help ... Steven M. and Kay L. Theede chair in ... engineering, and his research team have created a ... in car trunks. The distance detection method ...
Breaking Biology News(10 mins):Kessler Foundation awarded Department of Defense grant for spinal cord injury research 2Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3Patented research remotely detects nitrogen-rich explosives 2
(Date:1/15/2014)... IPSWICH, England , January 15, 2014 ... to win races on the Formula 1 track could help ... between McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based ... funded by healthcare provider Simplyhealth. Telemetry technology, which ...
(Date:1/15/2014)... January 15, 2014 2013 was a ... Brain State Technologies®. They saw continued independent research led ... who were awarded a $1 million grant from the ... “Brain and Behavior” a peer reviewed journal, Amy Grant ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have ... at 2pm EST (11am PST), “Natural Language Processing: Converting ... how technology can turn raw, heterogeneous data into actionable ... The online webinar will last approximately one hour. , ...
(Date:1/14/2014)... 2014 The largest international professional organization of ... therapeutic derivatives thereof has endorsed an educational program ... the challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8
Cached News: