HOME >> BIOLOGY >> NEWS
Unprecedented View Of RNA Structure Captured

Johns Hopkins Scientists Discover Protein 'Lynchpin'

A pioneering view of the internal structure of RNA captured by scientists at The Johns Hopkins University will become public today in a report published by the journal "Science."

The work of an interdisciplinary team of chemists and biophysicists marks the first actual atomic level resolution of a protein-RNA complex from the ribosome ever to be produced and only the third RNA ever to have its complex higher-order construction revealed.

"I've been traveling around the last few weeks giving talks about what we've discovered," said chemistry professor David Draper, out of whose lab the work originated, "and people's jaws just drop to the floor. So little has been known about how RNAs fit together and what kinds of structural features keep it intact. Well, now we can actually see it in 3-D, living color."

The detailed structure is significant because so little is known about it. Also, RNA's stature has risen extraordinarily in the past two decades with discoveries that RNA not only carries the genetic blueprint to the ribosomes for protein encoding, but also serves as the catalyst that carries out the reactions and does the major work of the ribosome. Its ability to both store genetic information and catalyze biological reactions identifies it as central to the origins of life and suggests that it is critical for the regulation of genes and pathogens.

Unfortunately, scientists still have only a primitive understanding of RNA. Its many entwined helical elements are tightly packed into an extremely complicated, globular structure, making even a simple viewing a difficult biophysical adventure.

By binding a particularly stable kind of protein commonly known as L11 to RNA synthesized in the lab, Draper's group created an RNA-protein complex that was at last robust enough to withstand the rigors of analysis--in this case, c
'"/>

Contact: Gary Dorsey
gdd@jhu.edu
410-516-7906
Johns Hopkins University
14-May-1999


Page: 1 2 3 4

Related biology news :

1. Unprecedented fire season in southern Africa aids air quality, climate change research
2. Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
3. Structure solved by Scripps scientists shows one way that body controls gene expression
4. Structure of a Nobel-prize winning molecule: Aquaporin
5. Structure of HIV-neutralizing antibody solved
6. Structure of key breast cancer receptor determined
7. Structure of cog at the hub of metabolism reveals anti-ageing function
8. Structure of pain-modulating enzyme described by scientists at the Scripps Research Institute
9. Structure reveals details of cells cargo-carriers
10. Structure of key receptor unlocked; Related proteins will fall like dominoes
11. New Science Press launches Proteins: From Sequence to Structure

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)... , Aug. 15 2017   ivWatch LLC , a ... intravenous (IV) therapy, today announced receipt of its ISO 13485 Certification, ... by the International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for the early ... "This is an ...
(Date:7/20/2017)... (NYSE: DAL ) customers now can use fingerprints instead of ... Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May ... boarding process to allow eligible Delta SkyMiles Members who are enrolled in ...
(Date:6/30/2017)... Va. , June 30, 2017 ... leading developer and supplier of face and eye ... ATA Featured Product provider program. ... an innovative way to monitor a driver,s attentiveness ... greatly from being able to detect fatigue and ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... , Aug. 15, 2017 After spending the past two ... with crowdsourced data collection, GeneFo now offers this platform to healthcare ... and amplifying support, adherence, and data collection vis a vis their ... mark the successful launch of this offer. ... GeneFo ...
(Date:8/15/2017)... ... August 15, 2017 , ... Kenall, a leader in ... to stay tightly sealed and perform efficiently for years. The downlights are ideal ... just aren't enough, such as: hospitals; behavioral health facilities; cleanrooms; containment areas; food ...
(Date:8/14/2017)... Portland, Oregon (PRWEB) , ... August 14, 2017 ... ... modules that provide essential device-to-computer interconnect using USB or PCI Express, announced the ... hardware. , SYZYGY is intended to satisfy the need for a compact, low ...
(Date:8/11/2017)... ... August 11, 2017 , ... ... and, in particular, more natural alternatives to synthetic ingredients,” said Matt Hundt, President ... Wave, with the established manufacturing presence and know-how of Biorigin will allow us ...
Breaking Biology Technology:
Cached News: