HOME >> BIOLOGY >> NEWS
Unprecedented View Of RNA Structure Captured

Johns Hopkins Scientists Discover Protein 'Lynchpin'

A pioneering view of the internal structure of RNA captured by scientists at The Johns Hopkins University will become public today in a report published by the journal "Science."

The work of an interdisciplinary team of chemists and biophysicists marks the first actual atomic level resolution of a protein-RNA complex from the ribosome ever to be produced and only the third RNA ever to have its complex higher-order construction revealed.

"I've been traveling around the last few weeks giving talks about what we've discovered," said chemistry professor David Draper, out of whose lab the work originated, "and people's jaws just drop to the floor. So little has been known about how RNAs fit together and what kinds of structural features keep it intact. Well, now we can actually see it in 3-D, living color."

The detailed structure is significant because so little is known about it. Also, RNA's stature has risen extraordinarily in the past two decades with discoveries that RNA not only carries the genetic blueprint to the ribosomes for protein encoding, but also serves as the catalyst that carries out the reactions and does the major work of the ribosome. Its ability to both store genetic information and catalyze biological reactions identifies it as central to the origins of life and suggests that it is critical for the regulation of genes and pathogens.

Unfortunately, scientists still have only a primitive understanding of RNA. Its many entwined helical elements are tightly packed into an extremely complicated, globular structure, making even a simple viewing a difficult biophysical adventure.

By binding a particularly stable kind of protein commonly known as L11 to RNA synthesized in the lab, Draper's group created an RNA-protein complex that was at last robust enough to withstand the rigors of analysis--in this case, c
'"/>

Contact: Gary Dorsey
gdd@jhu.edu
410-516-7906
Johns Hopkins University
14-May-1999


Page: 1 2 3 4

Related biology news :

1. Unprecedented fire season in southern Africa aids air quality, climate change research
2. Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
3. Structure solved by Scripps scientists shows one way that body controls gene expression
4. Structure of a Nobel-prize winning molecule: Aquaporin
5. Structure of HIV-neutralizing antibody solved
6. Structure of key breast cancer receptor determined
7. Structure of cog at the hub of metabolism reveals anti-ageing function
8. Structure of pain-modulating enzyme described by scientists at the Scripps Research Institute
9. Structure reveals details of cells cargo-carriers
10. Structure of key receptor unlocked; Related proteins will fall like dominoes
11. New Science Press launches Proteins: From Sequence to Structure

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, Inc. ... technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate governance ... Gino ... we look forward to their guidance and benefiting from their ...
(Date:4/5/2017)... , April 5, 2017 Today HYPR ... that the server component of the HYPR platform is ... providing the end-to-end security architecture that empowers biometric authentication ... HYPR has already secured over 15 million users across ... manufacturers of connected home product suites and physical access ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... For the second ... a US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, ... from US2020. , US2020’s mission is to change the trajectory of STEM education ...
(Date:10/10/2017)... SANTA CRUZ, Calif. , Oct. 10, 2017 /PRNewswire/ ... SBIR grant from the NIH to develop RealSeq®-SC (Single ... preparation kit for profiling small RNAs (including microRNAs) from ... Cell Analysis Program highlights the need to accelerate development ... "New techniques for ...
(Date:10/9/2017)... Oct. 9, 2017  BioTech Holdings announced today ... which its ProCell stem cell therapy prevents limb ... The Company, demonstrated that treatment with ProCell resulted ... saved as compared to standard bone marrow stem ... resulted in reduction of therapeutic effect.  ...
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... ... a four-tiered line of medical marijuana products targeting the needs of consumers who ... packaging of Kindred takes place in Phoenix, Arizona. , As operators of two ...
Breaking Biology Technology:
Cached News: