Untangling the matrix of risk factors for alcoholism

  • A family history of alcoholism places a person at greater risk of developing alcohol problems.
  • Children of alcoholics also tend to exhibit other types of behavioral and emotional problems.
  • The neurotransmitter serotonin is believed to regulate many behaviors and emotions.
  • Genetic variation in the serotonin transporter gene may partially determine overall levels of serotonergic function.

Children of alcoholics (COAs) have a high risk of developing alcoholism, simply by virtue of their family history of alcoholism. Many studies have found that COAs also tend to exhibit high levels of behavioral and emotional problems. In the July issue of Alcoholism: Clinical & Experimental Research, researchers explore the biochemical basis of two aspects of 'behaviors of undercontrol.' Their findings indicate that behavioral disinhibition (BD), such as impulsive aggression, and negative affect (NA), such as depression and anxiety, may be genetically influenced through the regulation of a neurotransmitter called serotonin (5-HT).

"Serotonin's primary role appears to be that of an inhibitor," explained Geoffrey R. Twitchell, Postdoctoral Fellow at the UCLA Integrated Substance Abuse Programs and lead author of the study. "Dysfunction in 5-HT neurotransmission has been found in individuals who exhibit problems with behavioral and affective control.

For example, 5-HT deficits have been observed in antisocial alcoholics who exhibit BD, such as aggressiveness and difficulty controlling alcohol consumption. The relationship between 5-HT dysfunction and impulsive aggression in non-alcoholic groups has also been reliably documented. In addition, many studies have found 5-HT dysfunction in individuals who exhibit increased NA, as indicated by depression and anxiety. Depressed and highly anxious individuals are often treated with 5-HT enhancing medications such as selective serotonergic reuptake inhibitors."


Contact: Geoffrey R. Twitchell, Ph.D.
Alcoholism: Clinical & Experimental Research

Page: 1 2 3

Related biology news :

1. Untangling the web of tropical biodiversity
2. Untangling The Protein Folding Problem
3. Umbilical cord matrix, a rich new stem cell source, study shows
4. Rice bioengineers develop method to grow 3-D bone matrix
5. Report in Science on x-ray crystal structure of matrix Metalloproteinase-2 (MMP-2)
6. Brain development and puberty may be key factors in learning disorders
7. High-fat fast-food breakfast produces rush of inflammatory factors into blood stream, UB study finds
8. Rimonbant shows promise in addressing multiple risk factors
9. Cells ability to open bloods floodgates hinges on unexpected factors
10. Variants of BMP2 gene as genetic risk factors for osteoporosis
11. Unemployment, access to guns among factors that turn domestic violence deadly

Post Your Comments:

(Date:2/6/2019)... , ... February 05, 2019 , ... ... today announced it has partnered with MindFuel, a leading organization in educational science, ... K-12 education. Amino Labs has pioneered a syn-bio starter kit for ...
(Date:2/2/2019)... ... 2019 , ... uBiome, the leader in microbial genomics, has ... requirements for medical laboratories to demonstrate competence to deliver timely, accurate, and reliable ... College of American Pathologists (CAP)-accredited, a designation given to the top three percent ...
(Date:1/25/2019)... ... 24, 2019 , ... Review methodology could negatively impact elderly, ... to grapple with prescription drug costs, a new Pioneer Institute study ... before deciding whether to contract with the Institute for Clinical and Economic Review ...
Breaking Biology News(10 mins):
(Date:1/20/2019)... (PRWEB) , ... January 17, 2019 , ... ... testing was, until recently, the exclusive purview of physicians. That's changing as many ... global direct to consumer (DTC) laboratory testing market totaled $208 million in 2018, ...
(Date:1/20/2019)... ... January 17, 2019 , ... Today, ... the launch of a specialized automation technology, titled Automate 3D. Automate 3D, produced ... of models and drawings to deliver to end-users, customers, and ERP systems. ...
(Date:1/15/2019)... (PRWEB) , ... January 15, 2019 , ... Personalized treatment ... for worsening kidney disease, according to a new study published in the journal Radiology. ... are frequently treated with partial nephrectomy, a surgical procedure in which the tumor and ...
(Date:1/11/2019)... ... January 11, 2019 , ... Boekel Scientific ... collection of donor blood. This advanced and intuitive medical device was designed ... the functionality needed for the busiest donor stations with new-to-the industry features to ...
Breaking Biology Technology:
Cached News: