Use Of Protease Inhibitors For HIV Associated With Dramatic Rise In Oral Warts

While the main oral infections associated with HIV infection and AIDS have been brought under control, the use of powerful new protease inhibitors to treat HIV has led to a dramatic, unexplained increase in oral warts among patients, a new study reveals.

Unlike the more treatable mouth and tongue infections, oral warts are difficult to control and highly prone to recur, says Deborah Greenspan, BDS, DSc, clinical professor of oral medicine in the UC San Francisco School of Dentistry and study principal investigator.

In addition, they are unsightly and uncomfortable, according to Greenspan. The warts can develop on the gums, tongue and lips, and can appear as an isolated lump or develop into a cauliflower-like mass. They often feel rough and interfere with eating.

"In the era of HAART (highly active antiretrovial therapy), we're seeing less of the common oral lesions, but an increase in oral warts caused by the human papillomavirus," Greenspan says. "We do not understand why this is happening."

HAART is the term for therapies, including protease inhibitors, that have been so successful in controlling HIV over the past few years.

The study of HIV-related oral infections was undertaken by a research team at the Oral AIDS Center in the UCSF Department of Stomatology. Results were presented yesterday (February 3) at the Sixth Conference on Retroviruses and Opportunistic Infections in Chicago.

The researchers analyzed the changes in oral infections detected in 3,542 HIV-positive patients at a special referral clinic of the Oral AIDS Center from 1990-98.

In addition to monitoring oral warts, the study noted changes in the prevalence of three conditions more commonly associated with HIV: oral candidiasis, a fungal infection that forms as patches in the mouth; hairy leukoplakia, non-removable white lesions on the tongue caused by a virus; and Kaposi's sarcoma, raised red oral lumps.

Oral candidiasis and hairy leukoplakia usually r

Contact: Wallace Ravven
University of California - San Francisco

Page: 1 2

Related biology news :

1. Protease-inhibitor cocktail protects, increases anti-microbial action of promising new peptide
2. Phase III Results Suggest Potent Antiviral Activity For Vertex And Glaxo Wellcomes Second-Generation HIV Protease Inhibitor Agenerase TM
3. New Class Of Protease Inhibitors May Be Effective In Treating One Of Latin Americas Most Devastating Diseases
4. HIV-Positive Injection Drug Users Often Dont Receive Protease Inhibitors And May Not Be Aware Of The Drug
5. Researchers Document Transmission Of Protease-Resistant HIV
6. How Super Are The "Super Aspirins"? -- New COX-2 Inhibitors May Elevate Cardiovascular Risk
7. Cholesterol Inhibitors In Garlic Identified
8. Researchers Find Protein Abnormality Associated With Alzheimers Disease
9. Risks For Heart Disease Associated With Size Of LDL Particles
10. Bacteria From Gum Infections Associated With Diabetes, Chronic Lung Disease, UB Studies Find
11. Variations In The Human Homologue Of A Fruit Fly Gene Are Associated With Mood And Panic Disorders

Post Your Comments:

(Date:7/19/2019)... ... July 19, 2019 , ... ... and Crystalline States – Insights from Synchrotron X-ray Pair Distribution (SXPDF) Studies”. The ... with Chris Benmore of Argonne National Laboratory and Gabriel de Araujo of the ...
(Date:7/17/2019)... (PRWEB) , ... July 17, ... ... the largest urology practice in the Southeast, and its acclaimed pediatric urologists ... Best Children’s Hospitals rankings. This annual recognition signifies excellence among the country’s ...
(Date:7/17/2019)... ... July 16, 2019 , ... At nearly eleven years old, Seve, ... According to his owner, in the last year or so, he was a little ... veterinarian, Dr. Cindy Echevarria of VCA University Animal Hospital in Dallas, diagnosed ...
Breaking Biology News(10 mins):
(Date:8/6/2019)... ... August 06, 2019 , ... The National Science Foundation (NSF) ... community project that will engage middle and early high school students in environmental ... Citizen Science Network for Community Environmental Assessment.” Collaborative partners presenting the authentic science ...
(Date:7/19/2019)... (PRWEB) , ... July 18, 2019 , ... ... Instrumente) announced their investment to enlarge their current piezo motion facilities in Lederhose, ... offer 3 floors for multilayer piezo ceramic assembly production in addition to general ...
(Date:7/11/2019)... , ... July 11, 2019 , ... At the most ... complimentary regenerative therapies to eight military Veterans under the R3 Heroes Program. The Veterans ... , The R3 Heroes Program allow anyone to nominate a military Veteran, teacher or ...
(Date:6/18/2019)... ... June 17, 2019 , ... IVERIC bio, ... an agreement for production and manufacturing of GMP-grade adeno-associated virus (AAV) vector for ... dominant retinitis pigmentosa (RHO-adRP) and IC-200 for the treatment of BEST1 related retinal ...
Breaking Biology Technology:
Cached News: