Use Of Protease Inhibitors For HIV Associated With Dramatic Rise In Oral Warts

espond to treatment, and Kaposi's sarcoma is now much rarer, Greenspan explains.

Incidence of all three oral conditions declined significantly year by year during the study period, the researchers found. In contrast, the incidence of oral warts increased dramatically from 1996-98, the period during which protease inhibitor treatments became more common.

The study examined the incidence of oral warts among those who were treated with protease inhibitors and other advanced antiretroviral (ARV) therapies, as well as those undergoing ARV treatment other than protease inhibitors. Finally, it compared both these groups with those not treated with any ARV therapy. Results showed that protease inhibitors specifically are associated with the great increase in oral warts, according to Greenspan.

"We have an apparently paradoxical increase in oral human HPV warts which appears to be an...unexpected complication of HAART," the researchers conclude. The increases in oral warts and decreases in the other three conditions were highly significant statistically, according to study

The UCSF team includes John Greenspan, BDS, PhD, director of the Oral AIDS Center and the AIDS Clinical Research Center, and chair of the stomatology department; Alison Canchola, MS, statistician for the Oral AIDS Center; Laurie MacPhail, PhD, DMD, associate clinical professor of stomatology; Behnaz Cheikh, DDS, a Fellow in stomatology; Herve Sroussi, DDS, postdoctoral scientist in stomatology; Joel Palefsky, MD, associate professor of laboratory medicine; and Joan Hilton, ScD, associate professor of epidemiology and biostatistics.


Contact: Wallace Ravven
University of California - San Francisco

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