HOME >> BIOLOGY >> NEWS
Use of new direct thrombin inhibitor may be as effective as current standard treatment

(San Diego, Calif., December 7, 2003) The use of ximelagatran in patients with acute venous thromboembolism is as safe and effective as the current standard treatment of enoxaparin, according to a study presented today during the 45th Annual Meeting of the American Society of Hematology (ASH). Ximelagatran is a novel oral direct thrombin inhibitor that, in its activated form, selectively inhibits free and clot-bound thrombin, a key enzyme in the body's coagulation pathway.

"We believe that ximelagatran holds promise as a new agent for the treatment of venous thromboembolism, a sometimes fatal disease that affects an estimated 250,000 to two million Americans a year," said Charles Francis, M.D., of the University of Rochester, Rochester, N.Y., presenting author of the study. "Further studies are needed to confirm its effectiveness over currently available treatments."

Researchers of this international, double-blind, double-dummy study (known as the Thrive Treatment Study) randomized 2,489 patients to either ximelagatran (36 mg twice a day) for six months (1,240 patients) or enoxaparin (1 mg/kg twice a day) for a minimum of five days followed by warfarin (target INR 2.0 to 3.0) for six months (1,249 patients). All participants, 53 percent of whom were men, had acute deep vein thrombosis and 37 percent had confirmed pulmonary embolism.

During six months of treatment, oral ximelagatran was as effective as enoxaparin/warfarin in preventing recurrent venous thromboembolism in patients with acute deep vein thrombosis, 2.1 percent versus 2.0 percent, respectively. Ximelagatran also was associated with a favorable outcome with respect to major bleeding (1.3 percent versus 2.2 percent) and mortality rates (2.3 percent versus 3.4 percent). Laboratory evaluation showed an incidence of serum alanine aminotransferase (ALAT, commonly measured to assess liver function) elevations of 9.6 percent, which is greater than three times the upper lim
'"/>

Contact: Aimee Frank
amf@spectrumscience.com
202-955-6222
American Society of Hematology
7-Dec-2003


Page: 1 2 3

Related biology news :

1. New dye directly reveals activated proteins in living cells
2. Fossils reveal direct link between global warming and genetic diversity in wildlife
3. UCSB professor and director receives two national awards
4. Briggs takes to the molecular level Darwins findings on plants sensing the direction of light
5. Molecular traffic cop directs cellular signals
6. Protein controls acid in cells by direct detection of volume changes, study finds
7. New research supports theory that indirect transmission of chronic wasting disease
8. Chemical reaction in birds provides sense of direction during migratory flights
9. Crowding stem cells personal space directs their future
10. New polyelectrolyte inks create fine-scale structures through direct writing
11. St. Jude/Mayo Clinic study finds direct link between CBP gene and lymphoma

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: