HOME >> BIOLOGY >> NEWS
Using a mouse model, reserchers now understand changes occurring in the brain before the onset of Huntington's disease

New highly efficient DNA array technology brings researchers one step closer to understanding the progression of Huntington's disease and the potential for the development of therapies

Huntington's disease affects nearly 30,000 people nationwide, with another 150,000 at risk for inheriting the disease. Like a genetic time bomb, one abnormal gene in Huntington's victims disrupts the brain's nerve cell functions, slowly degrading physical, intellectual and emotional capability and leading inevitably to death.

In a collaborative study conducted by the Fred Hutchinson Cancer Research Center (FHCRC) in Seattle and Massachusetts General Hospital (MGH) in Boston, researchers used a mouse model to identify changes that occur in nerve cells in the early stages of Huntington's disease. They identified several signaling molecules that could be targeted for future therapies. The results are reported in the May 22 issue of the journal Human Molecular Genetics.

Equally important to the knowledge gained is that the research team was able to do in six months what would have taken years in the past. Using new technologies in FHCRC's DNA Array Lab the team used genetic microchips--called microarrays--to survey the patterns of active and non-active genes at early and late symptomatic stages in a mouse model of Huntington's disease.

The research teams, led by Drs. Jim Olson, a pediatric oncologist at FHCRC, University of Washington and Children's Hospital and Regional Medical Center, and Ruth Luthi-Carter, a neurobiologist at MGH, monitored nearly 6,000 genes in the brain region most damaged by Huntington's disease. They found a small subset of genes to be affected by the disease, only two percent of the total. Importantly, many of the affected genes code the molecules that brain cells need to receive and process messages.

"The mouse models provide a window into the early stages of the disease," says Luthi-Carter. "This unders
'"/>

Contact: Susan Edmonds
sedonds@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
21-May-2000


Page: 1 2 3 4

Related biology news :

1. Using statistics to decipher secrets of natural mutation
2. Using science to restore habitat for declining species
3. Using soils as filters to prevent crypto from moving to the groundwater
4. Using a companion crop to control weeds organically
5. Using plants and microbes to purify polluted industrial wastewater
6. Using GPR to estimate tree root biomass
7. Using computational power tools to bolster systems biology
8. Using RNA interference to tune gene activity in stem cells
9. Using sewage sludge as fertilizer
10. Using the oceans living light shows to fight terrorism or track the planets most massive migration
11. Using genetic research to treat inflammatory diseases Vienna centre of excellence in biomedicine harnesses basic research

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: