HOME >> BIOLOGY >> NEWS
Using statistics to decipher secrets of natural mutation

A new mathematical approach for analyzing the complex, subtle patterns of natural mutation in DNA will, according to its developers, help biologists understand how mutation contributes to evolutionary change in mammals.

The researchers, Howard Hughes Medical Institute investigator Phil Green and his student Dick Hwang, published a description of their new analytical approach and an initial application August 3, 2004, in the online early edition of the Proceedings of the National Academy of Sciences. Both are at the University of Washington in Seattle.

"Understanding naturally occurring mutations has been of great interest because mutations are major drivers of evolution," said Green. "However, it's surprising how little is still known about their causes."

Previous studies have revealed a number of biases in the rates of different types of mutational change. These arise in part from the innate biochemical characteristics of the four DNA nucleotide units adenine, guanine, cytosine and thymine that affect their vulnerability to modification and the accuracy with which they are replicated when cells divide. Particular nucleotide sequences, for example cytosine-guanine (CpG) dinucleotides, form "hotspots" regions that are particularly vulnerable to alterations that convert one nucleotide to another, causing mutations.

To understand these biases, Hwang and Green sought to develop a flexible approach to analyze the process of "neutral DNA evolution," in regions thought to lack genes and other functionally important sequences. "If you want to get an unvarnished picture of the mutation process itself, uncorrupted by natural selection, you want to look at neutrally evolving DNA," said Green. "Mutations in DNA that is not functional should better represent the complete spectrum of naturally occurring mutations. Mutations are of course also occurring in the genes and those are of interest because they can create new phenotypes and cause variati
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
16-Aug-2004


Page: 1 2 3 4

Related biology news :

1. Using science to restore habitat for declining species
2. Using soils as filters to prevent crypto from moving to the groundwater
3. Using a companion crop to control weeds organically
4. Using plants and microbes to purify polluted industrial wastewater
5. Using GPR to estimate tree root biomass
6. Using computational power tools to bolster systems biology
7. Using RNA interference to tune gene activity in stem cells
8. Using sewage sludge as fertilizer
9. Using the oceans living light shows to fight terrorism or track the planets most massive migration
10. Using genetic research to treat inflammatory diseases Vienna centre of excellence in biomedicine harnesses basic research
11. Using brain activity to identify risk for disorders

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/9/2019)... ... July 09, 2019 , ... Murrieta ... into its incubator program. The founder and CEO of Tx Genetic, Helen Harrison, ... of those suffering from epithelial connective tissue disorders. , “We are pleased and ...
(Date:7/5/2019)... ... July 05, 2019 , ... SteriTrack Inc. is ... Platform to governments around the world. , Powered by Microsoft Azure, the ... care solutions to operating theatres worldwide to address new global regulations mandating all ...
(Date:6/24/2019)... ... June 24, 2019 , ... According to the World Health Organization ... most common STDs: chlamydia, gonorrhea, trichomoniasis (or "trich") and syphilis. And that’s not counting ... African American men accounted for the largest number of HIV diagnoses (9,807), followed by ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... 10, 2019 , ... Thought Technology Ltd is pleased to ... Biofeedback Tech Ltd as its authorised distributor for the UK and Ireland. ... treatments and clinical assessment protocols to treat stress related disorders as well as ...
(Date:6/11/2019)... ... June 10, 2019 , ... ... add 80 of its scientific journals to DeepDyve’s rental service for peer-reviewed journals. ... continually expanding library of more than 20 million articles, sourced from more than ...
(Date:6/11/2019)... ... June 11, 2019 , ... ... Stem Cells Inc. (PSC) , has announced that their GMP facility for cell ... Drug Branch for manufacturing. This is an important milestone for VetStem as ...
(Date:6/6/2019)... ... June 05, 2019 , ... WCCT Global, Inc ., ... industries, announced today that they will be receiving 3 awards at the 2019 CRO ... received 2 awards in the categories of overall Quality and Compatibility (Access to desired ...
Breaking Biology Technology:
Cached News: