Uterine Environment Boosts Learning Ability In Mouse Offspring

BAR HARBOR, ME. -- A study conducted at The Jackson Laboratory and the University of Connecticut suggests that the maternal uterine environment in mice can have an enhancing effect on learning ability in offspring across a broad range of behaviors.

"The Uterine Environment Enhances Cognitive Competence" appears in the current issue of the British scientific journal NeuroReport, published Friday, Feb. 27. Authors are Victor H. Denenberg and Blair J. Hoplight, both of the University of Connecticut at Storrs, and Larry E. Mobraaten of The Jackson Laboratory.

"It's well-known that malnutrition, drugs, alcohol, and other factors can have devastating effects on fetuses," says Dr. Denenberg, who has worked as a visiting investigator at The Jackson Laboratory. "But this is one of the first studies to show that a positive uterine environment can have profound effects upon adult cognitive behavior." The research was supported in part by the National Institutes of Health.

The uterine environment study involved genetically identical mouse embryos of a strain known as BXSB/MpMob-+Yaa. The BXSB strain, developed at The Jackson Laboratory, is a popular model for the study of lupus-like autoimmune diseases and such conditions in mice as neocortical ectopias similar to those found in the brains of human dyslexics.

The embryos were divided into three groups for the experiment. The Non-Transfer group consisted of BXSB mothers with natural embryo implantation. The In-Strain Transfer group had BXSB mothers with transplanted embryos. And the Out-Strain Transfer group consisted of non-automimmune CB6F1 hybrid mothers with transplanted embryos. The Non-Transfer and Out-Strain pups were delivered vaginally and reared by their mothers; the In-Strain pups were delivered by Cesarean section and reared by foster CB6F1 hybrid mothers.

At six weeks of age, the offspring from the three groups were given a series of behavioral tests

Contact: Luther Young
(207) 288-6052
Jackson Laboratory

Page: 1 2

Related biology news :

1. Gene Therapy May Suppress Uterine Fibroids
2. Environmental issues center of Inland Northwest Research Alliance 4th Annual Symposium
3. Environmental decontamination, greenhouse gases, and the genome of a methane-loving bacterium
4. Environmental costs of home construction lower with wise choice, reuse of building materials
5. Environment influences learning: U of T study
6. NIH funds Breast Cancer and the Environmental Research Center at Fox Chase Cancer Center
7. UCR graduate student wins best poster at Environmental Mutagen Society Meeting
8. Water and the Environment
9. Environment loses to economic development in local policy-making
10. Jane Goodall to receive 2003 Global Environmental Citizen Award
11. Jane Goodall to receive 2003 Environmental Citizen Award

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: