HOME >> BIOLOGY >> NEWS
Vaccine Kills Spreading Cancer In Animal Model

Johns Hopkins scientists have developed a vaccine that, in mice, can alert the immune system to the presence of stray cancer cells and significantly reduce their blood-borne spread.

"Metastatic cancer, or cancer that is spreading from its site of origin, is among the toughest stages of cancer to treat," says Hongxiu Ji, M.D., postdoctoral fellow. "Our findings suggest cancer vaccines could be an important tool for preventing and treating the spread of cancers."

Giving the vaccine prior to a tail vein injection of cancer cells prevented development of metastatic lung tumors in eight of 10 mice, while all the mice in two control groups that received cancer cells but no vaccine developed tumors. A second test against established lung cancer showed that the vaccine completely eliminated tumors in 50 percent of mice.

Ji presents her results, funded by the National Institutes of Health and the Richard W. TeLinde endowment, at this week's meeting of the American Society of Gene Therapy in Seattle.

The vaccine takes advantage of a protein, E7, produced by the human papilloma virus and commonly found in cervical cancers and their metastatic cancers. To make the vaccine, scientists altered vaccinia, a common virus, to include a gene for E7 and a molecular signal. The vaccine infects cells in the body, causing them to make E7, and the molecular signal triggers a chain reaction that calls E7 to the immune system's attention. This leads to an immune system attack on all cells that contain the protein--including the cancer cells.

To test whether the vaccine is effective against metastatic cervical cancer, Ji and her colleagues developed a line of tumor cells by genetically altering mouse lung cells to include E7. This made the cells similar to cervical cancer cells. She then showed that a tail vein injection of the cancer cells could cause lung tumors in mice in two weeks.

Tests showed the vaccine could
'"/>

Contact: Michael Purdy
mpury@jhmi.edu
(410)955-8725
Johns Hopkins Medical Institutions
2-Jun-1998


Page: 1 2 3

Related biology news :

1. Hope Clinic of Emory Vaccine Center receives CDC contract
2. Vaccines against foodborne disease on horizon
3. GenVec, U.S. NMRC, and PATHs Malaria Vaccine Initiative partner to expand malaria vaccine efforts
4. Vaccine technique shows potential against common form of lung cancer
5. Fighting fire with fire? Vaccine based on chimp virus shows promise against HIV
6. Emory Vaccine Research Center study identifies specific gene required for long-term immunity
7. Vaccine prevents stroke in rats
8. Vaccine puts blood-sucking ticks off their food
9. Vaccine protects against fatal West Nile complication
10. Dr. Robert C. Gallo to Collaborate with Visiting Israeli Scientist on Promising HIV Vaccine Research at Marylands Institute of Human Virology
11. Vaccine controls AIDS in monkeys, researchers report in Science

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2017)... -- Aware, Inc. (NASDAQ: AWRE ), a leading supplier ... its quarter and year ended December 31, 2016. ... million compared to $6.9 million in the same quarter last ... $0.6 million compared to $2.6 million in the fourth quarter ... was $0.5 million, or $0.02 per diluted share, which compares ...
(Date:2/8/2017)... Feb. 7, 2017 The biometrics market ... the confluence of organizations, desires to better authenticate ... systems (password and challenge questions), biometrics is quickly ... systems. The market is driven by use cases, ... consumer and enterprise uses cases, with consumer-facing use ...
(Date:2/7/2017)... Minn. , Feb. 7, 2017   MedNet ... supports the entire spectrum of clinical research, is pleased ... iMedNet , its innovative, highly flexible and award ... iMedNet customers. iMedNet is a proven ... provides Electronic Data Capture (EDC), but also delivers an ...
Breaking Biology News(10 mins):
(Date:2/28/2017)... ... February 28, 2017 , ... Patient travel ... and expertise. Colpitts Clinical Trial Travel and Expense , a division of ... unique need within the biotechnology and pharmaceutical industries in the United States, Europe, ...
(Date:2/28/2017)... , ... February 28, 2017 , ... Over 8,000 recognized ... In a new educational webinar on March 7, DrugDev will gather international ... in this especially difficult area. , Webinar: Overcoming the Challenges of Rare Disease ...
(Date:2/28/2017)... Diego, California (PRWEB) , ... February 28, 2017 ... ... and supports high-growth, high-impact life science and biotechnology companies today announced it ... entrepreneurial communities, will be based out of Durham, NC and will begin work ...
(Date:2/28/2017)... RepliCel Life Sciences Inc. (OTCQB:REPCF) (TSXV:RP) (FRA:P6P2) ("RepliCel" or ... unique biologic products for pattern baldness and thinning hair, ... announced it has recently signed agreements with two European ... RepliCel to get the Company,s commercial-grade RCI-02 dermal injector ... ...
Breaking Biology Technology:
Cached News: