HOME >> BIOLOGY >> NEWS
Variation of gene associated with decreased risk of heart attack and stroke

Individuals who have a variation of the COX-2 gene have an associated lower risk for a heart attack or stroke, according to a study in the May 12 issue of The Journal of the American Medical Association (JAMA).

Although myocardial infarction (MI, or heart attack) and atherothrombotic ischemic stroke are thought to be caused by rupture of vulnerable atherosclerotic plaques, they are recognized to be complex disorders that likely result from multifaceted interactions between an individual's genetic makeup and environmental factors, according to background information in the article. The relation between COX-2 variations and the risk of MI and stroke has not been clear.

Francesco Cipollone, M.D., of the G. d'Annunzio University of Chieti and G. d'Annunzio University Foundation, Chieti, Italy and colleagues conducted a study to determine if there was a relationship between a variation in the COX-2 gene (termed the "-765G-C polymorphism") and clinically evident plaque rupture. The study was conducted between March 2002 and October 2003 among 864 patients with first MI or atherothrombotic ischemic stroke and 864 hospitalized controls. The groups were matched for age, sex, body mass index, smoking, hypertension, hypercholesterolemia, and diabetes.

The researchers found that the prevalence of this specific genetic variation (-765GC) was 2.41 times higher among the controls than among the MI and stroke patients. The prevalence of a different variant (-765CC) was 5.81 times higher among the controls than among the MI and stroke patients. Patients with the -765GC or -765CC genotype had a reduction in relative risk of MI and ischemic stroke of 52 percent and 67 percent, respectively, after adjustment for age, sex, smoking status, body mass index, hypercholesterolemia, hypertension, and diabetes.

"We found that the -765GC polymorphism of the COX-2 gene is associated with a reduction in the risk of MI and stroke, suggesting that this [v
'"/>

Contact: Andrea Mezzetti, M.D.
mezzetti@unich.it
JAMA and Archives Journals
11-May-2004


Page: 1 2

Related biology news :

1. Variations in food density affect calorie consumption
2. Variations in a gene that regulates food intake are associated with anorexia nervosa
3. Variations In The Human Homologue Of A Fruit Fly Gene Are Associated With Mood And Panic Disorders
4. Soil Variation Important In Natural Plant Communities
5. Simian virus 40 not associated with non-Hodgkin lymphoma, study shows
6. IBD (Crohns, Colitis) joins cancer, inflammatory diseases in associated blood vessel growth
7. Common therapy for HIV associated with cervical abnormality regression
8. Milk consumption and calcium intake associated with lower colorectal cancer risk
9. Severe depression associated with greater number of nerve cells in thalamus region of brain
10. Calcium supplements associated with decreased risk of large bowel polyps
11. NIH funds new Boston College-Boston University study of B-1a cell associated with leukemia

Post Your Comments:
(Date:12/24/2014)... in December 2014, the 1U™ app has helped ... remember their usernames and passwords through replacing the antiquated system ... people who have struggled to remember usernames and passwords, ... on redefining identity, announced today that it is offering the ...
(Date:12/22/2014)... Dec. 22, 2014 Research and Markets ... the "The Global Watermarking and Fingerprinting Markets" ... http://photos.prnewswire.com/prnh/20130307/600769 This insight ... watermarking and fingerprinting markets. Watermarking aims to control ...
(Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) ... Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology ... http://photos.prnewswire.com/prnh/20130307/600769 Following the acquisition ... reading feature with the iPhone 5S. It is currently ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3The Global Watermarking and Fingerprinting Markets 2iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2
(Date:1/22/2015)... 22, 2015  Transwestern | RBJ today announces the firm brokered ... for Shire a leading biopharmaceutical company, at Two Ledgemont Center ... Robert Richards , president, and Brian Cohen , ... entire five-floor building at 95 Hayden Ave. Photo ...
(Date:1/22/2015)... CO / Rootstown, OH (PRWEB) January 22, 2015 ... detection platform, announced today that it has received AOAC-PTM Certifications ... O45, O1O3, O111, O121, and O145; collectively referred to as ... coli) O157, at 1 colony forming unit (cfu) per 325 ...
(Date:1/22/2015)... January 22, 2015 Controlled Substance Compliance ... which helps companies check the legal requirements around using ... to China. , As their international operations expand ... adopting software solutions built as a result of the ...
(Date:1/22/2015)... , Jan. 22, 2015   Cypher Genomics, ... Sequenom, Inc. (NASDAQ: SQNM ), the ... agreement for next generation noninvasive prenatal tests (NIPT). ... interpretation technology, called Mantis™, to advance analysis of ...
Breaking Biology Technology:Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Global Compliance Service for Controlled Substances to Expand to China 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4
Cached News: