HOME >> BIOLOGY >> NEWS
Variation of gene associated with decreased risk of heart attack and stroke

Individuals who have a variation of the COX-2 gene have an associated lower risk for a heart attack or stroke, according to a study in the May 12 issue of The Journal of the American Medical Association (JAMA).

Although myocardial infarction (MI, or heart attack) and atherothrombotic ischemic stroke are thought to be caused by rupture of vulnerable atherosclerotic plaques, they are recognized to be complex disorders that likely result from multifaceted interactions between an individual's genetic makeup and environmental factors, according to background information in the article. The relation between COX-2 variations and the risk of MI and stroke has not been clear.

Francesco Cipollone, M.D., of the G. d'Annunzio University of Chieti and G. d'Annunzio University Foundation, Chieti, Italy and colleagues conducted a study to determine if there was a relationship between a variation in the COX-2 gene (termed the "-765G-C polymorphism") and clinically evident plaque rupture. The study was conducted between March 2002 and October 2003 among 864 patients with first MI or atherothrombotic ischemic stroke and 864 hospitalized controls. The groups were matched for age, sex, body mass index, smoking, hypertension, hypercholesterolemia, and diabetes.

The researchers found that the prevalence of this specific genetic variation (-765GC) was 2.41 times higher among the controls than among the MI and stroke patients. The prevalence of a different variant (-765CC) was 5.81 times higher among the controls than among the MI and stroke patients. Patients with the -765GC or -765CC genotype had a reduction in relative risk of MI and ischemic stroke of 52 percent and 67 percent, respectively, after adjustment for age, sex, smoking status, body mass index, hypercholesterolemia, hypertension, and diabetes.

"We found that the -765GC polymorphism of the COX-2 gene is associated with a reduction in the risk of MI and stroke, suggesting that this [v
'"/>

Contact: Andrea Mezzetti, M.D.
mezzetti@unich.it
JAMA and Archives Journals
11-May-2004


Page: 1 2

Related biology news :

1. Variations in food density affect calorie consumption
2. Variations in a gene that regulates food intake are associated with anorexia nervosa
3. Variations In The Human Homologue Of A Fruit Fly Gene Are Associated With Mood And Panic Disorders
4. Soil Variation Important In Natural Plant Communities
5. Simian virus 40 not associated with non-Hodgkin lymphoma, study shows
6. IBD (Crohns, Colitis) joins cancer, inflammatory diseases in associated blood vessel growth
7. Common therapy for HIV associated with cervical abnormality regression
8. Milk consumption and calcium intake associated with lower colorectal cancer risk
9. Severe depression associated with greater number of nerve cells in thalamus region of brain
10. Calcium supplements associated with decreased risk of large bowel polyps
11. NIH funds new Boston College-Boston University study of B-1a cell associated with leukemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
(Date:3/31/2016)... March 31, 2016   ... or the "Company") LegacyXChange is excited to ... its soon to be launched online site for trading ... ) will also provide potential shareholders a sense ... technology to an industry that is notorious for fraud. ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... New York , April 29, 2016 /PRNewswire/ ... report published by Transparency Market Research "Separation Systems ... Size, Share, Growth, Trends, and Forecast 2015 - ... was valued at US$ 10,665.5 Mn in 2014 ... of 6.8% from 2015 to 2023 to reach ...
(Date:4/29/2016)... ... April 29, 2016 , ... Summit for Stem Cell has received ... of a patient-specific stem cell therapy for the treatment of Parkinson’s disease. The Summit ... Loring at The Scripps Research Institute in San Diego, CA. , The ...
(Date:4/29/2016)... April 29, 2016 Elekta is ... update to its industry-leading treatment planning software, is available ... Monaco version 5.11 provides significant performance ... calculation speeds up to four times faster than in ... the industry,s gold standard Monte Carlo ...
(Date:4/28/2016)... 2016 Q BioMed Inc. ... CEO  was featured in an article he wrote ... Fear To Tread: http://www.lifescienceleader.com/doc/accelerators-enter-when-vcs-fear-to-tread-0001 ... is an essential business journal for life science ... to Big Pharmas. Their content is designed to ...
Breaking Biology Technology:
Cached News: