HOME >> BIOLOGY >> NEWS
Variation of gene associated with decreased risk of heart attack and stroke

Individuals who have a variation of the COX-2 gene have an associated lower risk for a heart attack or stroke, according to a study in the May 12 issue of The Journal of the American Medical Association (JAMA).

Although myocardial infarction (MI, or heart attack) and atherothrombotic ischemic stroke are thought to be caused by rupture of vulnerable atherosclerotic plaques, they are recognized to be complex disorders that likely result from multifaceted interactions between an individual's genetic makeup and environmental factors, according to background information in the article. The relation between COX-2 variations and the risk of MI and stroke has not been clear.

Francesco Cipollone, M.D., of the G. d'Annunzio University of Chieti and G. d'Annunzio University Foundation, Chieti, Italy and colleagues conducted a study to determine if there was a relationship between a variation in the COX-2 gene (termed the "-765G-C polymorphism") and clinically evident plaque rupture. The study was conducted between March 2002 and October 2003 among 864 patients with first MI or atherothrombotic ischemic stroke and 864 hospitalized controls. The groups were matched for age, sex, body mass index, smoking, hypertension, hypercholesterolemia, and diabetes.

The researchers found that the prevalence of this specific genetic variation (-765GC) was 2.41 times higher among the controls than among the MI and stroke patients. The prevalence of a different variant (-765CC) was 5.81 times higher among the controls than among the MI and stroke patients. Patients with the -765GC or -765CC genotype had a reduction in relative risk of MI and ischemic stroke of 52 percent and 67 percent, respectively, after adjustment for age, sex, smoking status, body mass index, hypercholesterolemia, hypertension, and diabetes.

"We found that the -765GC polymorphism of the COX-2 gene is associated with a reduction in the risk of MI and stroke, suggesting that this [v
'"/>

Contact: Andrea Mezzetti, M.D.
mezzetti@unich.it
JAMA and Archives Journals
11-May-2004


Page: 1 2

Related biology news :

1. Variations in food density affect calorie consumption
2. Variations in a gene that regulates food intake are associated with anorexia nervosa
3. Variations In The Human Homologue Of A Fruit Fly Gene Are Associated With Mood And Panic Disorders
4. Soil Variation Important In Natural Plant Communities
5. Simian virus 40 not associated with non-Hodgkin lymphoma, study shows
6. IBD (Crohns, Colitis) joins cancer, inflammatory diseases in associated blood vessel growth
7. Common therapy for HIV associated with cervical abnormality regression
8. Milk consumption and calcium intake associated with lower colorectal cancer risk
9. Severe depression associated with greater number of nerve cells in thalamus region of brain
10. Calcium supplements associated with decreased risk of large bowel polyps
11. NIH funds new Boston College-Boston University study of B-1a cell associated with leukemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/30/2019)... ... September 30, 2019 , ... ... of innovative human mesenchymal stem/stromal cell (hMSC) biomanufacturing systems, today announced it ... “Ready-to-Print” (RTP) cellular product formats (patent number AU 2015259373). This new patent ...
(Date:9/25/2019)... ... 25, 2019 , ... The esteemed dental implant specialists at ... for a variety of procedures, including single tooth replacement, new “teeth-in-a-day” immediately functioning ... implants offer patients permanent tooth replacement solutions that look and function very ...
(Date:9/25/2019)... ... September 25, 2019 , ... ... collaboration and dialogue, today announces its inaugural South CEO conference to ... Louisiana. , Co-produced by Tulane University, this invitation-only meeting convenes biopharma executives ...
Breaking Biology News(10 mins):
(Date:10/3/2019)... ... , ... Yesterday, at the 2019 meeting of Outsourcing in Clinical Trials New ... M.D., Ph.D., discussed important design factors that currently limit the success of early stage ... of clinical trials, in his talk Dr. Sherley focused on the highly ...
(Date:9/24/2019)... ... September 24, 2019 , ... ... research in the area of high-level X-ray methods using synchrotron-produced X-rays to ... of Improved Pharma, will present “Synchrotron X-Ray Diffraction and Pair Distribution Function ...
(Date:9/24/2019)... ... September 24, 2019 , ... ... and manufacturing solutions for drugs, biologics, gene therapies, and consumer health products, ... the development of therapies to treat central nervous system (CNS) disorders, today ...
(Date:9/24/2019)... ... September 24, 2019 , ... ... PhD, RD, to its Scientific Advisory Board. Dr. Holscher is an Assistant Professor ... Division of Nutritional Sciences at the University of Illinois Urbana-Champaign, where she has ...
Breaking Biology Technology:
Cached News: