HOME >> BIOLOGY >> NEWS
Variations In The Human Homologue Of A Fruit Fly Gene Are Associated With Mood And Panic Disorders

Polymorphisms Of The Human Homologue Of The Drosophila White Gene Are Associated With Mood And Panic Disorders

The fruit fly (Drosophila melanogaster) white gene is a member of the ATP-binding cassette (ABC) transporter superfamily and is involved in the cellular uptake of tryptophan. Its human homologue gene (hW) has been mapped to chromosome 2lq22.3. Tryptophan is the precursor for the neurotransmitter serotonin, which has been implicated In the regulation of mood and anxiety. The locus 2lq22.3 has also been reported to be associated with mood disorders. The 3 prime untranslated region (3'-UTR) in the hW gene has been shown to contain a polymorphic poly(T) region. Investigators at Ehime University in Japan have now identified a new polymorphism G2457A in the 3'-UTR. They examined the relationship between these polymorphisms and mood and panic disorders. A significant association between the poly(T) polymorphisms and mood disorders was detected [P = 0.039 (allele frequency)]. Associations were found between the polymorphisms and mood [poly(T) polymorphism: P = 0.047 (allele frequency), G2457A: P = 0.040 (allele frequency), P = 0.044 (genotype frequency)] and panic disorders [G2457A: P = 0.026 (allele frequency), P = 0.011 (genotype frequency)] in males, but not In females. These findings suggest that the hW gene may be an important gene In the control of mood and anxiety as well as one of the genetic factors related to mood disorders and panic disorder In males. The statistical significance of the association remains relatively low and larger materials facilitating further dissection of the clinical phenotype will be needed to confirm and independently validate this finding and to evaluate its significance.


'"/>

Contact: Julie Vianello
j.vianello@stockton-press.co.uk
301-496-6885
Molecular Psychiatry
1-Mar-1999


Page: 1

Related biology news :

1. Variations in food density affect calorie consumption
2. Variations in a gene that regulates food intake are associated with anorexia nervosa
3. Human chromosome 5 final sequence analysis released to public
4. Humans march to a faster genetic drummer than primates, UC Riverside research says
5. Applied Mathematical Models in Human Physiology
6. Human health risks in space flight focus of research internships
7. Human periodontal ligament stem cells isolated for the first time
8. Organization for Human Brain Mapping 2004 Annual Meeting
9. 20 May AAAS lecture: Computers that Respond to Human Emotion
10. Human brain works heavy statistics learning language
11. New Woods Hole Center for Oceans and Human Health established

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)... ivWatch LLC , a medical device company focused on improving the ... its ISO 13485 Certification, the global standard for medical device quality ... ... device for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, as it validates ...
(Date:5/23/2017)... first robotic gym for the rehabilitation and functional motor sense evaluation of ... Italy . The first 30 robots will be available from June ... . The technology was developed and patented at the IIT laboratories and ... thanks to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017 International research firm Parks Associates ... will speak at the TMA 2017 Annual Meeting , October 11 ... in the residential home security market and how smart safety and security ... Parks Associates: ... "The residential security ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program Committee ... honoring scientists who have made outstanding contributions to analytical chemistry and applied ... the world’s leading conference and exposition for laboratory science, which will be held ...
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... At its ... Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, has ... was a member of the winning team for the 2015 Breakthrough Prize in Fundamental ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... and applications consulting for microscopy and surface analysis, Nanoscience Instruments is now ... Analytical offers a broad range of contract analysis services for advanced applications. ...
Breaking Biology Technology:
Cached News: