HOME >> BIOLOGY >> NEWS
Variations In The Human Homologue Of A Fruit Fly Gene Are Associated With Mood And Panic Disorders

Polymorphisms Of The Human Homologue Of The Drosophila White Gene Are Associated With Mood And Panic Disorders

The fruit fly (Drosophila melanogaster) white gene is a member of the ATP-binding cassette (ABC) transporter superfamily and is involved in the cellular uptake of tryptophan. Its human homologue gene (hW) has been mapped to chromosome 2lq22.3. Tryptophan is the precursor for the neurotransmitter serotonin, which has been implicated In the regulation of mood and anxiety. The locus 2lq22.3 has also been reported to be associated with mood disorders. The 3 prime untranslated region (3'-UTR) in the hW gene has been shown to contain a polymorphic poly(T) region. Investigators at Ehime University in Japan have now identified a new polymorphism G2457A in the 3'-UTR. They examined the relationship between these polymorphisms and mood and panic disorders. A significant association between the poly(T) polymorphisms and mood disorders was detected [P = 0.039 (allele frequency)]. Associations were found between the polymorphisms and mood [poly(T) polymorphism: P = 0.047 (allele frequency), G2457A: P = 0.040 (allele frequency), P = 0.044 (genotype frequency)] and panic disorders [G2457A: P = 0.026 (allele frequency), P = 0.011 (genotype frequency)] in males, but not In females. These findings suggest that the hW gene may be an important gene In the control of mood and anxiety as well as one of the genetic factors related to mood disorders and panic disorder In males. The statistical significance of the association remains relatively low and larger materials facilitating further dissection of the clinical phenotype will be needed to confirm and independently validate this finding and to evaluate its significance.


'"/>

Contact: Julie Vianello
j.vianello@stockton-press.co.uk
301-496-6885
Molecular Psychiatry
1-Mar-1999


Page: 1

Related biology news :

1. Variations in food density affect calorie consumption
2. Variations in a gene that regulates food intake are associated with anorexia nervosa
3. Human chromosome 5 final sequence analysis released to public
4. Humans march to a faster genetic drummer than primates, UC Riverside research says
5. Applied Mathematical Models in Human Physiology
6. Human health risks in space flight focus of research internships
7. Human periodontal ligament stem cells isolated for the first time
8. Organization for Human Brain Mapping 2004 Annual Meeting
9. 20 May AAAS lecture: Computers that Respond to Human Emotion
10. Human brain works heavy statistics learning language
11. New Woods Hole Center for Oceans and Human Health established

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/18/2018)... ... October 18, 2018 , ... Avastus Preclinical Services LLC, a ... of its new West Cambridge flagship facility scheduled for December 1, 2018. The ... tissue culture, necropsy and surgery rooms will give the company a strong foothold ...
(Date:10/17/2018)... ... October 17, 2018 , ... ... life sciences, diagnostics, and scientific healthcare companies, proudly announces Insights: Scientific Healthcare ... South San Francisco. In conjunction with co-producer Biocom, the association representing the ...
(Date:10/16/2018)... ... October 16, 2018 , ... Nanomedical Diagnostics ... a new publication titled, “ Graphene-based Biosensor for On-Chip Detection of Bio-Orthogonally Labeled ... R100 as a “new portable digital device for biosensing… that can be employed ...
Breaking Biology News(10 mins):
(Date:10/2/2018)... , ... October 02, 2018 , ... ... Locus Bio-Energy Solutions™, LLC’s (Locus Bio-Energy) AssurEOR product line was chosen for its ... and Gulf Energy Information, honor leading innovations in upstream oil applications that are ...
(Date:9/29/2018)... , ... September 29, 2018 , ... ... enabling mid-level and early-stage companies to access the power of influence analytics and ... solutions available to a broader market that didn’t necessarily have access to the ...
(Date:9/27/2018)... ... September 26, 2018 , ... ... B. Melina Cimler, a senior quality, regulatory, and in vitro diagnostic device expert ... global diagnostic industry has joined the firm as an Expert Consultant. Her experience ...
(Date:9/27/2018)... LOS ANGELES (PRWEB) , ... September 26, 2018 ... ... medical device and biologics manufacturer, debuted its focus® Pedicle Screw System today at ... Convention Center, September 26-29. , The Nvision focus Pedicle Screw System, ...
Breaking Biology Technology:
Cached News: