HOME >> BIOLOGY >> NEWS
Vascular disease and aging

rosclerosis.

The authors of a new study entitled, "Alterations in Gene Expression During Progressive Aging in Rat Thoracic Aorta," are Steven J. Miller and Joseph L. Unthank, Methodist Research Institute, Clarian Health, Indianapolis, IN and William C. Watson and Kimberly A. Kerr, Department of Surgery, Indiana University School, of Medicine, Indianapolis, IN. They will present their findings during the upcoming scientific conference, Understanding Renal and Cardiovascular Function Through Physiological Genomics, a meeting of the American Physiological Society (APS) (www.the-aps.org), being held October 1-4, 2003 at the Radisson Riverfront Hotel and Convention Center, Augusta, GA.

Methodology

In their earlier work, the researchers used oligonucleotide microarray analysis to investigate progressive age-mediated changes in gene expressions to demonstrate that vascular remodeling occurs in rat aorta with progressive aging. In the current study, thoracic aorta was harvested from 3-, 6-, 15-, and 28-month old F344xBNrats and total RNA was isolated. Microarray analysis was conducted using a standard protocol. Four biologic replicates were used for each age.

Results

The researchers found:

  • that the total number of genes with significant (p<0.01) changes in expression increased with progressive aging compared to 3-month old rats (11, 21, and 277 genes at 6, 15, and 28 months, respectively);
  • inflammatory-associated adhesion molecules ICAM-1 and VCAM-1 had significantly (p< 0.01) increased expression at 28 vs. 6 months (2.1x and 3.7x, respectively), as well as 28 vs. 15 months (1.6x and 2.0, respectively);
  • ICAM-1/VCAM-1 expression also increased at 15 vs. 6 months, but was not statistically significant; and
  • other functional groups of genes that were significantly altered with age at 28 vs. 6 months included increased
    '"/>


Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
30-Sep-2003


Page: 1 2 3

Related biology news :

1. Vascular access vital to pump up tissue engineering
2. Vascular Surgeons Test New Treatment For Abdominal Aneurysms
3. Study Links Viruses And Vascular Diseases
4. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
5. Alzheimers disease is not accelerated aging
6. New molecular link key to cellular proteins involved in cancer progression, other diseases
7. Wildlife Conservation Society hosts public symposium on human-wildlife diseases
8. University of Alberta researcher looks for clues to mysterious disease
9. Study explores gene transfer to modify underlying course of Alzheimers disease
10. Experimental drug shown to block mutant protein causing blood disease
11. Algal contact as a trigger for coral disease

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Vascular disease and aging

(Date:7/29/2014)... Swimming microorganisms, such as bacteria and spermatozoa, are subjected ... forces exerted by the surrounding fluid. Such low-level ... found that the direction of propulsion made possible by ... viscoelastic fluid. These findings have been published in ... Energies and Atomic Energy Commission (CEA), in Le Barp, ...
(Date:7/29/2014)... Northern Territories in Canada and have sent smoke drifting ... on. NASA,s Aqua satellite collected this natural-color image ... July 26, 2014. Actively burning areas, detected by MODIS,s ... smoke are drifting northward in this image. Smoke ... Fire has caused power outages in the area and ...
(Date:7/29/2014)... New research from scientists at the University of Kent ... inside cells are regulated a breakthrough that could ... A team from Kent,s School of Biosciences uncovered the ... within cells known as actin filaments are ... these actin filaments appear to completely stable, providing a ...
Breaking Biology News(10 mins):Optimum inertial self-propulsion design for snowman-like nanorobot 2
(Date:7/29/2014)... South Carolina (PRWEB) July 29, 2014 DisasterTalk ... teams of people where cell phone masts or other transmitters ... up to 100 feet away without the need for any ... target longer ranges. , The new app has launched as ... US homes are at very high risk of being affected ...
(Date:7/29/2014)... G-CON Manufacturing Inc., the standard in design ... new leadership appointment designed to drive the company’s ambitious ... , Maik Jornitz, Chief Operating Officer of G-Con Manufacturing, ... leading the pioneering company through its next phase of ... development and look forward to providing our next generation ...
(Date:7/29/2014)... The prestigious "Discovery or Exploration in ... awarded to Juliana Hillis and Kaylie O’Connell, students at ... “From an Egg, Everything: America’s First IVF Baby". This ... the National History Day program during a week-long final ... in Washington, D.C. , The growing popularity of the ...
(Date:7/29/2014)... Lehigh Acres, FL (PRWEB) July 29, 2014 ... (FIB) ex situ lift out specimen preparation solutions, has ... and Trademark Office for specimen manipulation methods incorporating a ... Patent 8,740,209. This is the second company patent ... Lucille A. Giannuzzi. , These complementary patents ...
Breaking Biology Technology:DisasterTalk App Could Save Lives as Report Reveals 8% of US Homes at Very High Risk of Natural Disaster 2G-CON Manufacturing, Inc. Announces Maik Jornitz as President 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 3EXpressLO LLC Granted Second U.S. Patent for Innovative Specimen Preparation Methods 2
Cached News: