The authors of a new study entitled, "Alterations in Gene Expression During Progressive Aging in Rat Thoracic Aorta," are Steven J. Miller and Joseph L. Unthank, Methodist Research Institute, Clarian Health, Indianapolis, IN and William C. Watson and Kimberly A. Kerr, Department of Surgery, Indiana University School, of Medicine, Indianapolis, IN. They will present their findings during the upcoming scientific conference, Understanding Renal and Cardiovascular Function Through Physiological Genomics, a meeting of the American Physiological Society (APS) (www.the-aps.org), being held October 1-4, 2003 at the Radisson Riverfront Hotel and Convention Center, Augusta, GA.
In their earlier work, the researchers used oligonucleotide microarray analysis to investigate progressive age-mediated changes in gene expressions to demonstrate that vascular remodeling occurs in rat aorta with progressive aging. In the current study, thoracic aorta was harvested from 3-, 6-, 15-, and 28-month old F344xBNrats and total RNA was isolated. Microarray analysis was conducted using a standard protocol. Four biologic replicates were used for each age.
The researchers found: