HOME >> BIOLOGY >> NEWS
Vertex Researchers Report Three-Dimensional Atomic Structure Of JNK3 Enzyme; Report In Structure

Vertex researchers have solved the three-dimensional atomic structure of the JNK3 enzyme, a research advance that may pave the way for new drugs to treat epilepsy and stroke. The discovery, which represents the first known structure of JNK3, will be published in the August 15, 1998 issue of the journal Structure.

JNK3 belongs to the MAP Kinase family of enzymes, a group of proteins that help to transmit signals from the surface of cells to the nucleus, allowing cells to respond to their environment. Pharmaceutical industry interest in JNK3 stems from animal studies that implicate JNK3 in neurological diseases such as epilepsy. Genomic research has shown that mice bred to be deficient in JNK3 show reduced susceptibility to seizure and neuronal cell death.

Vertex's has an established track record of applying structural information to genomic discoveries as part of an effort to discover new drugs against innovative targets. Vertex employs an interdisciplinary approach that integrates biophysics, biology and chemistry towards the efficient design and development of novel pharmaceuticals.


'"/>

Contact: Michael Partridge
partridge@vpharm.com
(617) 577-6108
Vertex Pharmaceuticals
14-Aug-1998


Page: 1

Related biology news :

1. Research Findings Suggest Potent, Broad-Spectrum Antiviral Activity For Vertexs Investigational IMPDH Inhibitor VX-497
2. Phase III Results Suggest Potent Antiviral Activity For Vertex And Glaxo Wellcomes Second-Generation HIV Protease Inhibitor Agenerase TM
3. Vertex Pharmaceuticals/Yale Research Team Uses Gene Knockout Mice To Establish Role Of Caspase-9 In Neuronal Cell Death Pathway
4. Vertex Pharmaceuticals Researchers Report Three-Dimensional Structure Of Hepatitis C Helicase Enzyme; Report In Structure
5. Researchers determine genetic cause of Timothy syndrome
6. Researchers find color sensitive atomic switch in bacteria
7. Researchers identify protein promoting vascular tumor growth
8. Researchers devise potent new tools to curb ivory poaching
9. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
10. Researchers ID chlorophyll-regulating gene
11. Researchers develop fast track way to discover how cells are regulated

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... April 5, 2017  The Allen Institute for Cell ... Explorer: a one-of-a-kind portal and dynamic digital window into ... data, the first application of deep learning to create ... cell lines and a growing suite of powerful tools. ... these and future publicly available resources created and shared ...
(Date:3/30/2017)...  On April 6-7, 2017, Sequencing.com will host the ... hackathon at Microsoft,s headquarters in Redmond, Washington ... developing health and wellness apps that provide a unique, ... is the first hackathon for personal genomics and ... in the genomics, tech and health industries are sending ...
(Date:3/27/2017)... 2017  Catholic Health Services (CHS) has been ... (HIMSS) Analytics for achieving Stage 6 on the ... In addition, CHS previously earned a place in ... electronic medical record (EMR). "HIMSS Analytics ... EMR usage in an outpatient setting.  This recognition ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... Diego, CA (PRWEB) , ... ... ... (https://www.onramp.bio/ ) has launched Rosalind™, the first-ever genomics analysis platform specifically ... all bioinformatics complexity. Named in honor of pioneering researcher Rosalind Franklin, who ...
(Date:10/11/2017)... ... 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for its 4th ... in San Francisco, CA. The Summit brings together current and former FDA office bearers, ... and government officials from around the world to address key issues in device compliance, ...
(Date:10/11/2017)... Georgia (PRWEB) , ... October 11, 2017 , ... Disappearing ... taking the lives of over 5.5 million people each year. Especially those living in ... greenovative startup Treepex - based in one of the most pollution-affected countries globally - ...
(Date:10/10/2017)... Angeles, CA (PRWEB) , ... ... ... Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, ... uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in ...
Breaking Biology Technology:
Cached News: