HOME >> BIOLOGY >> NEWS
Very Fruitful Collaboration Between French And German Scientists Yields Unusual Insights Into The Structure Of Membrane Proteins

Biomolecular NMR 1997, 10, 95-106), this now allowed the use of neutron spectroscopy to address specific dynamics which has, for the first time, been tackled in a membrane protein. The experiments were performed at the High-Flux Neutron Reactor of the Institut von Laue-Langevin in Grenoble.

Elastic incoherent neutron scattering (EINS) experiments on selectively deuterated bacteriorhodopsin, which make it possible to define amplitudes of thermal motions in the nano- to picosecond time-scale, have revealed a dynamic transition from a harmonic to a softer, inharmonic atomic fluctuation regime in the global behavior of the protein. Biological activity in proteins is correlated with this transition, suggesting that this type of flexibility is a prerequisite for function. The thermal motions of the labeled atoms in the heart of the protein, however, demonstrate stiffer behavior and, at room temperature, they have significantly smaller amplitudes of motion. Contrary to the bulk mean behavior, they appear to be shielded from solvent melting effects. These experimental results quantify the dynamical heterogeneity of bacteriorhodopsin, which meets the functional requirements of bulk flexibility, on the one hand, to allow large conformational changes in the molecule, and of a harder core, on the other, to control stereo-specific conformation changes of the central retinal.

It was shown here that protein atoms move in potential wells of different shapes and temperature characteristics, depending on their location in the structure. The EINS experiments have proven to be sufficiently sensitive to quantify this dynamical heterogeneity. The neutron approach yields the most direct and possibly unique qua
'"/>

Contact: Dieter Oesterhelt
oesterhe@biochem.mpg.de
+49-89-8578-2386
Max-Planck-Gesellschaft
14-May-1998


Page: 1 2 3 4

Related biology news :

1. Creation of the UK Clinical Research Collaboration will boost clinical trials in UK
2. Collaboration at EMSL produces innovative mass spectrometer
3. Collaboration to use proteomics to unravel mysteries of heart disease
4. Collaboration advances potential therapy for autoimmune diseases
5. Abgenix and Chiron enter Xenomouse Technology Collaboration, targets antibody products for autoimmune disease and cancer
6. University-Industry-Government Institute Will Study Pollution Control Chemistry In A Unique Virtual Collaboration
7. US-Cuban Scientific Collaborations Jeopardized By Travel Restrictions
8. UB Study Finds No Relationship Between Male Consumption Of Lake Ontario Fish And Conception Delay
9. Jefferson Scientists Find Link Between Learning And Preventing Alzheimers
10. UI Researchers Find Possible Genetic Link Between The X Chromosome And Ovarian Cancer
11. Scientists Devise Method To Address Conflict Between Molecular Clock, Fossil Record Of Mammalian Evolution

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2019)... ... May 23, 2019 , ... ... for sales and service organizations, today announced its inclusion in DMG Consulting’s ... as the intelligent virtual agent (IVA) market share leader, based on number of ...
(Date:5/22/2019)... N.J. (PRWEB) , ... May 22, 2019 , ... ... custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical ... partnership agreement with Industrial Production Processes (IPP) Ltd has been ...
(Date:5/21/2019)... ... May 21, 2019 , ... If a genetically or synthetically ... we tell it apart from the millions of microorganisms that exist naturally in ... including Eric Young , assistant professor of chemical engineering at Worcester Polytechnic ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... ... May 03, 2019 , ... More than three ... Pesquisas Association, the scientist and ufologist Urandir Fernandes de Oliveira, last Thursday (25), ... the results of some research carried out by the association, in partnership with ...
(Date:5/2/2019)... , ... May 02, 2019 , ... ... testing company, will present results documenting discrepancies between U.S. insurer policies for genetic ... patients at risk for hereditary breast and ovarian cancer (HBOC). , ...
(Date:4/16/2019)... ... 2019 , ... On April 24th, the Federal Laboratory Consortium ... for Environmental Health Research (USACEHR), with an award for their cooperative effort in ... company located at the Frederick Innovative Technology Center, Inc. (FITCI) on Metropolitan Court, ...
(Date:4/10/2019)... , ... April 10, 2019 , ... After more than ... The new kitchen is equipped with updated appliances and modern lighting and fixtures, ... Jolla-based venue. , “We’ve seen tremendous growth in the demand for our ...
Breaking Biology Technology:
Cached News: