HOME >> BIOLOGY >> NEWS
Viral Harpoon Structure Suggests Measles, HIV And Ebola Viruses Related

the order, or sequence, of amino acids that make up a protein – of many different paramyxovirus fusion protein molecules revealed that their basic structures are all similar.

But when the scientists analyzed the three-dimensional structure of the simian virus fusion protein, they were surprised to discover close structural similarities to fusion proteins from HIV, influenza and Ebola, said Lamb. Aside from this similarity, he said, "all these viruses have very different strategies for infecting cells and insinuating viral genetic material into the target cells to commandeer their machinery."

According to Lamb, the similarity among such widely varied viruses suggests that they might have had some common ancestor that shared a primitive version of the fusion protein. It is impossible at this point, however, to pinpoint the evolutionary origin of that ancestry, he said.

Regardless, said Lamb. "knowing the structure of this one fusion protein may lead to the development of drugs capable of thwarting the action of the fusion proteins of other members of the paramyxovirus family, and even possibly its distant viral cousins." At the least, he added, these findings will spur further studies involving other medically important viruses.

Specifically, determining the three-dimensional structure of the fusion protein sheds new light on the key event in paramyxovirus infection — when the virus unfolds itself to reveal a spikelike protein that is launched into the gel-like outer membrane of the target cell. "It's much like a harpoon going into a target," said Lamb.

He emphasized, however, that more research is needed to answer two important questions: What triggers the harpoon molecule to unfurl, and how does the fusion protein refold itself to draw the virus toward the ensnared target cell? "What happens there is a mystery," he said. "It's like spearing a shark. It’s relatively easy to spear it, but getting it onboard the boat
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
26-Mar-1999


Page: 1 2 3

Related biology news :

1. Viral suspect for amphibian decline traced to human spread through bait
2. Viral proteins may prevent bacterial infections
3. Viral immunosuppression: Not just a game of hide and go seek
4. Viral protein may be associated with human brain tumors
5. Viral proteins may be associated with human brain tumors, according to findings by Temple researchers
6. New Study By TSRI Scientists Sheds Light On Viral Clearance In Acute Hepatitis B Infection
7. Antiviral From Advanced Viral Research Corp. Inhibits CCR5 Cell Receptor For HIV
8. Newly Discovered Viral Gateway Into Cells Could Play Role In Diagnosis And Treatment Of Leukemia, HIV And Other Viral Diseases
9. Novel Viral Vaccine Protects Aids In Animal Model
10. Viral Vector Delivers Dystophin Gene To Mouse Muscle
11. Experts Say That Future Inhaled Anti-Viral Drug, Zanamivir Is Effective For Treatment And Prevention Of Influenza

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
(Date:4/6/2017)... LONDON , April 6, 2017 ... Control, RFID, ANPR, Document Readers, by End-Use (Transportation & ... Energy Facility, Oil, Gas & Fossil Generation Facility, Nuclear ... Healthcare, Educational, Other) Are you looking for ... Authentication sector? ...
(Date:4/5/2017)... 2017 Today HYPR Corp. , leading ... component of the HYPR platform is officially FIDO® ... security architecture that empowers biometric authentication across Fortune 500 ... secured over 15 million users across the financial services ... home product suites and physical access represent a growing ...
Breaking Biology News(10 mins):
(Date:9/17/2017)... ... September 17, 2017 , ... GeneOne Life Science, Inc. announces ... Drug Safety (KMFDS) for an Investigational New Drug application for a Phase I/IIa ... (MERS-CoV). The study in Korea represents the second clinical trial for GLS-5300. ...
(Date:9/14/2017)... ... September 14, 2017 , ... ... its extensive experience with Health Economics and Outcomes Research (HEOR) and ‘big data’ ... testing. In 2014, US healthcare spending exceeded $3.0 trillion with nearly 1/3 spent ...
(Date:9/13/2017)... ... September 13, 2017 , ... AMRI, a ... to improve patient outcomes and quality of life for more than 25 years, ... a US expert to the International Standards Organization/Technical Committee 194: Biological and ...
(Date:9/12/2017)... ... September 12, 2017 , ... It wasn’t just the San ... been hot, hot, hot, as Lajollacooks4u has had a record-breaking number of guests for ... from far and wide to celebrate company outings, family get-togethers, anniversaries and milestone birthdays. ...
Breaking Biology Technology:
Cached News: