HOME >> BIOLOGY >> NEWS
Viral Harpoon Structure Suggests Measles, HIV And Ebola Viruses Related

the order, or sequence, of amino acids that make up a protein – of many different paramyxovirus fusion protein molecules revealed that their basic structures are all similar.

But when the scientists analyzed the three-dimensional structure of the simian virus fusion protein, they were surprised to discover close structural similarities to fusion proteins from HIV, influenza and Ebola, said Lamb. Aside from this similarity, he said, "all these viruses have very different strategies for infecting cells and insinuating viral genetic material into the target cells to commandeer their machinery."

According to Lamb, the similarity among such widely varied viruses suggests that they might have had some common ancestor that shared a primitive version of the fusion protein. It is impossible at this point, however, to pinpoint the evolutionary origin of that ancestry, he said.

Regardless, said Lamb. "knowing the structure of this one fusion protein may lead to the development of drugs capable of thwarting the action of the fusion proteins of other members of the paramyxovirus family, and even possibly its distant viral cousins." At the least, he added, these findings will spur further studies involving other medically important viruses.

Specifically, determining the three-dimensional structure of the fusion protein sheds new light on the key event in paramyxovirus infection — when the virus unfolds itself to reveal a spikelike protein that is launched into the gel-like outer membrane of the target cell. "It's much like a harpoon going into a target," said Lamb.

He emphasized, however, that more research is needed to answer two important questions: What triggers the harpoon molecule to unfurl, and how does the fusion protein refold itself to draw the virus toward the ensnared target cell? "What happens there is a mystery," he said. "It's like spearing a shark. It’s relatively easy to spear it, but getting it onboard the boat
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
26-Mar-1999


Page: 1 2 3

Related biology news :

1. Viral suspect for amphibian decline traced to human spread through bait
2. Viral proteins may prevent bacterial infections
3. Viral immunosuppression: Not just a game of hide and go seek
4. Viral protein may be associated with human brain tumors
5. Viral proteins may be associated with human brain tumors, according to findings by Temple researchers
6. New Study By TSRI Scientists Sheds Light On Viral Clearance In Acute Hepatitis B Infection
7. Antiviral From Advanced Viral Research Corp. Inhibits CCR5 Cell Receptor For HIV
8. Newly Discovered Viral Gateway Into Cells Could Play Role In Diagnosis And Treatment Of Leukemia, HIV And Other Viral Diseases
9. Novel Viral Vaccine Protects Aids In Animal Model
10. Viral Vector Delivers Dystophin Gene To Mouse Muscle
11. Experts Say That Future Inhaled Anti-Viral Drug, Zanamivir Is Effective For Treatment And Prevention Of Influenza

Post Your Comments:
(Date:5/21/2015)... DALLAS , May 21, 2015 ... report, "Thermal Imaging Market by Solutions (Hardware, Software, Services), ... Veterinary, Automotive & others), by End-Users (Military & ... published by MarketsandMarkets, Thermal Imaging Market is expected ... $9998.9 Million by 2020, at a Compound Annual ...
(Date:5/19/2015)... YORK , May 19, 2015  Technology is ... both internally and in the cloud. Passwords and their ... use of OTP and standards-based specifications such as those ... the outmoded use of passwords presents for BYOD, COPE, ... a unified biometric identity protocol. In ...
(Date:5/11/2015)... Calif. , May 11, 2015  Synaptics ... of human interface solutions, today announced the appointment ... President and Chief Financial Officer, reporting to ... replaces Synaptics, current Chief Financial Officer, Kathleen ... 2014. Mr. Ali brings extensive ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
(Date:5/28/2015)... May 28, 2015 The Academy of Model ... Aviation Day on August 15, 2015. National Model Aviation Day ... and to introduce model flying to the general public. , ... clubs to participate in the celebration by hosting events in ... host National Model Aviation Day events. View our online ...
(Date:5/28/2015)... 28, 2015 BioNorth Texas (BioNorthTX), ... representing the life sciences industry in northern region ... meeting at The Foundry in Dallas on April ... brought together a broad spectrum of biotech professionals ... organization's early successes in partnering with key life ...
(Date:5/28/2015)... May 28, 2015  GenVec, Inc. (Nasdaq: GNVC ... Douglas J. Swirsky , will present a company overview ... a.m. EDT on Thursday, June 4, 2015. ... presentation will be available at the following link:  ... GenVec,s website.  To access, visit www.genvec.com , click ...
(Date:5/28/2015)... 28, 2015 Whitehouse Laboratories is excited ... long term partnership with PTI Inspection Systems. Whitehouse Labs ... clients with custom-tailored method development and validation programs ... available. The agreement includes a more formal program that ... organizational lines. This enables a more effective team approach, ...
Breaking Biology Technology:Model flying pilots celebrate the Academy of Model Aeronautics Foundation’s Third Annual National Model Aviation Day 2BioNorthTX Holds Inaugural Board of Directors Meeting 2BioNorthTX Holds Inaugural Board of Directors Meeting 3GenVec To Present At The Jefferies Healthcare Conference 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 3
Cached News: