HOME >> BIOLOGY >> NEWS
Viral Harpoon Structure Suggests Measles, HIV And Ebola Viruses Related

the order, or sequence, of amino acids that make up a protein – of many different paramyxovirus fusion protein molecules revealed that their basic structures are all similar.

But when the scientists analyzed the three-dimensional structure of the simian virus fusion protein, they were surprised to discover close structural similarities to fusion proteins from HIV, influenza and Ebola, said Lamb. Aside from this similarity, he said, "all these viruses have very different strategies for infecting cells and insinuating viral genetic material into the target cells to commandeer their machinery."

According to Lamb, the similarity among such widely varied viruses suggests that they might have had some common ancestor that shared a primitive version of the fusion protein. It is impossible at this point, however, to pinpoint the evolutionary origin of that ancestry, he said.

Regardless, said Lamb. "knowing the structure of this one fusion protein may lead to the development of drugs capable of thwarting the action of the fusion proteins of other members of the paramyxovirus family, and even possibly its distant viral cousins." At the least, he added, these findings will spur further studies involving other medically important viruses.

Specifically, determining the three-dimensional structure of the fusion protein sheds new light on the key event in paramyxovirus infection — when the virus unfolds itself to reveal a spikelike protein that is launched into the gel-like outer membrane of the target cell. "It's much like a harpoon going into a target," said Lamb.

He emphasized, however, that more research is needed to answer two important questions: What triggers the harpoon molecule to unfurl, and how does the fusion protein refold itself to draw the virus toward the ensnared target cell? "What happens there is a mystery," he said. "It's like spearing a shark. It’s relatively easy to spear it, but getting it onboard the boat
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
26-Mar-1999


Page: 1 2 3

Related biology news :

1. Viral suspect for amphibian decline traced to human spread through bait
2. Viral proteins may prevent bacterial infections
3. Viral immunosuppression: Not just a game of hide and go seek
4. Viral protein may be associated with human brain tumors
5. Viral proteins may be associated with human brain tumors, according to findings by Temple researchers
6. New Study By TSRI Scientists Sheds Light On Viral Clearance In Acute Hepatitis B Infection
7. Antiviral From Advanced Viral Research Corp. Inhibits CCR5 Cell Receptor For HIV
8. Newly Discovered Viral Gateway Into Cells Could Play Role In Diagnosis And Treatment Of Leukemia, HIV And Other Viral Diseases
9. Novel Viral Vaccine Protects Aids In Animal Model
10. Viral Vector Delivers Dystophin Gene To Mouse Muscle
11. Experts Say That Future Inhaled Anti-Viral Drug, Zanamivir Is Effective For Treatment And Prevention Of Influenza

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/19/2016)... TORONTO , 19 de diciembre de 2016  Mosaic Biomedicals ... el desarrollo acelerado de MSC-1, un anticuerpo humanizado que se espera ... en 2017, con múltiples sitios previstos a lo largo de Europa ... MSC-1 ... factor inhibidor de leucemia (LIF), una citoquina pleiotrópica que se sobreexpresa ...
(Date:12/15/2016)... 15, 2016   WaferGen Bio-systems, Inc. (NASDAQ: ... company, announced today that on December 13, 2016, it ... The Nasdaq Stock Market LLC which acknowledged that, as ... WaferGen,s common stock had been at $1.00 or greater ... compliance with Listing Rule 5550(a)(2) of the Nasdaq Stock ...
(Date:12/12/2016)... 12, 2016  Researchers at Trinity College, Dublin, ... by combining the material with Silly Putty. The mixture ... detector able to sense pulse, blood pressure, respiration, ... The research team,s findings were ... here:  http://science.sciencemag.org/content/354/6317/1257 ...
Breaking Biology News(10 mins):
(Date:1/21/2017)... PARSIPPANY, N.J. , Jan. 20, 2017 /PRNewswire/ ... the "Company"), a company that provides clinically useful ... that it has entered into a securities purchase ... aggregate of 855,000 shares of common stock in ... placement, the Company has agreed to sell to ...
(Date:1/21/2017)... 20, 2017 Aratana Therapeutics, Inc. (NASDAQ: ... the licensing, development and commercialization of innovative biopharmaceutical products ... Company in North America 2016. ... based on the FDA approval of three innovative ... ® (capromorelin oral solution) and NOCITA ® ...
(Date:1/20/2017)... ... 2017 , ... The two newest companies to join the University City Science ... out from The Wistar Institute, and Sanguis, launched by a trio of students from ... , Vironika is developing a treatment for a chronic viral infection and its associated ...
(Date:1/20/2017)... 20, 2017 Ginkgo Bioworks, the organism ... pioneer in the synthesis and assembly of DNA. ... assembling pathway-length synthetic DNA into Ginkgo,s automated organism ... the construction of new organism designs for application ... "Gen9 was founded to significantly increase the world,s ...
Breaking Biology Technology:
Cached News: