HOME >> BIOLOGY >> NEWS
Viral proteins may prevent bacterial infections

KEY BISCAYNE, FL August 5, 2004 --Researchers from Rockefeller University are enlisting proteins produced by viruses in a novel strategy that may someday help prevent bacterial infections in hospitals and nursing homes.

Bacterial viruses, or bacteriophage, worm their way into bacterial cells, copy themselves and then, as an exit strategy, produce enzymes that quickly destroy the bacterial cell wall, killing the bacteria and releasing the viral offspring.

"These are highly evolved enzymes that work efficiently and rapidly to kill specific bacteria. The best use of these enzymes is to decolonize humans from carrying pathogenic bacteria in certain settings, such as hospitals, nursing homes and day care centers," says Vincent Fischetti, who is presenting data today at the American Society for Microbiology's Conference on the New Phage Biology.

Bacteria such as group A streptococci, Streptococcus pneumoniae and Staphylococcus aureus are common causes of infections, ranging from minor skin infections and ear infections in day care centers to deadly pneumonia in nursing homes and hospitals. In most instances human beings are the only reservoir of these bacteria, often carrying them unknowingly in their nose or throat. Enzymes targeting these bacteria could be delivered orally or nasally to reduce or eliminate colonization.

"If you greatly reduce the number of bacteria that are carried by individuals in these settings, the chance of infection will be minimized or even eliminated," says Fischetti.

In animal model experiments, Fischetti and his colleagues colonized mice with streptococcal or pneumococcal bacteria, either orally or nasally. They were able to remove the colonization completely using phage enzymes delivered in a single dose.

Because these enzymes are derived from viruses that infect and kill specific bacteria, they are like smart bombs that target and kill only the species or strain of bacteria for whic
'"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
5-Aug-2004


Page: 1 2

Related biology news :

1. Viral suspect for amphibian decline traced to human spread through bait
2. Viral immunosuppression: Not just a game of hide and go seek
3. Viral protein may be associated with human brain tumors
4. Viral proteins may be associated with human brain tumors, according to findings by Temple researchers
5. New Study By TSRI Scientists Sheds Light On Viral Clearance In Acute Hepatitis B Infection
6. Viral Harpoon Structure Suggests Measles, HIV And Ebola Viruses Related
7. Antiviral From Advanced Viral Research Corp. Inhibits CCR5 Cell Receptor For HIV
8. Newly Discovered Viral Gateway Into Cells Could Play Role In Diagnosis And Treatment Of Leukemia, HIV And Other Viral Diseases
9. Novel Viral Vaccine Protects Aids In Animal Model
10. Viral Vector Delivers Dystophin Gene To Mouse Muscle
11. Experts Say That Future Inhaled Anti-Viral Drug, Zanamivir Is Effective For Treatment And Prevention Of Influenza

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... ARMONK, N.Y. and ITHACA, N.Y. ... IBM ) and Cornell University, a leader in dairy ... combined with bioinformatics designed to help reduce the chances ... breaches. With the onset of this dairy project, Cornell ... the Consortium for Sequencing the Food Supply Chain, a ...
(Date:5/23/2017)... 2017  Hunova, the first robotic gym for the rehabilitation and functional ... in Genoa, Italy . The first 30 robots will ... USA . The technology was developed and patented at ... IIT spin-off Movendo Technology thanks to a 10 million euro investment from ... click: ...
(Date:5/16/2017)... DALLAS , May 16, 2017   ... for health organizations, and MD EMR Systems ... certified development partner for GE, have established a ... Patient Portal product and the GE Centricity™ products, ... Centricity EMR. These new integrations ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 ... London (ICR) and University of ... prognostic tool to risk-stratify patients with multiple myeloma (MM), in ... nine . The University of Leeds ... by Myeloma UK, and ICR will perform the testing services ...
(Date:10/11/2017)... Tampa Bay, Florida (PRWEB) , ... October 11, ... ... Food and Drug Administration (FDA) has granted orphan drug designation to SBT-100, its ... antibody (sdAb) for the treatment of osteosarcoma. SBT-100 is able to cross the ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the ... won a US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to ... Experience from US2020. , US2020’s mission is to change the trajectory of STEM ...
(Date:10/10/2017)... Calif. , Oct. 10, 2017 SomaGenics ... from the NIH to develop RealSeq®-SC (Single Cell), expected ... for profiling small RNAs (including microRNAs) from single cells ... Program highlights the need to accelerate development of approaches ... "New techniques for measuring levels ...
Breaking Biology Technology:
Cached News: