Virus Linked To Causing Enlarged Hearts In Children With Certain Genetic Makeup

DALLAS, Texas, Aug. 25 -- A certain virus may make the body turn against itself in some children, leading to development of an enlarged heart, say scientists in today's Circulation: Journal of the American Heart Association.

Although researchers already know that inflammation can lead to idiopathic (cause unknown) dilated cardiomyopathy -- a condition in which the heart becomes enlarged and functions poorly -- there has been uncertainty about the mechanism by which the specific virus causes this sometimes fatal disease.

In a study of three children who developed myocarditis -- a heart disease triggered by infection, which precedes cardiomyopathy -- researchers found evidence that the immune system was responding in an unusually aggressive way to certain proteins called antigens. Antigens are located in viruses, and they trigger the cells in the body's immune system to respond.

The children's genetic background made them more susceptible to this virus, which led to an overreaction of the normal immune system response, making a relatively common virus -- coxsackievirus B (CVB) -- potentially deadly.

"There are many different variants of this virus and most all children are exposed to it, but they all don't develop myocarditis," says the study's senior author, Massimo Trucco, M.D., director, division of immunogenetics, Children's Hospital of Pittsburgh and professor of pediatrics of the University of Pittsburgh School of Medicine. "Fortunately, only some of these variants have certain genetic sequences that direct the virus to the target organ, in this case, the heart."

Among the various viruses, some may have a genetic sequence, which turns regular antigens into "super" antigens, powerful enough to trigger a more aggressive immune response. In the children studied, a superantigen led in part to the powerful response triggering the development of an enlarged heart. Once this form of CVB invades the body, it can cause the immune system to overreac

Contact: Brian Henry
(214) 706-1135
American Heart Association

Page: 1 2 3

Related biology news :

1. Virus known for its photo ops makes its movie screen debut
2. Viruses clear bacterial contamination in chickens
3. Viruses may be environmentally friendly decontaminants
4. The Virus-Cancer Link: Examining the Role of Viruses in the Development of Cancer
5. Virus researchers close in on the secret life of DNA
6. Virus beats food bug
7. West Nile Virus cases analyzed for prevalence and symptoms
8. West Nile Virus can cause polio-like symptoms
9. Antibodies critical for fighting West Nile Virus infection
10. CDC Telebriefing: Smallpox educational activities and West Nile Virus update
11. West Nile Virus capsid protein causes encephalitic inflammation by triggering cell suicide

Post Your Comments:

(Date:3/30/2017)... 30, 2017 Trends, opportunities and forecast in ... by technology (fingerprint, AFIS, iris recognition, facial recognition, hand ... by end use industry (government and law enforcement, commercial ... banking, and others), and by region ( North ... Asia Pacific , and the Rest of ...
(Date:3/27/2017)... March 27, 2017  Catholic Health Services (CHS) ... Systems Society (HIMSS) Analytics for achieving Stage 6 ... sm . In addition, CHS previously earned a ... using an electronic medical record (EMR). ... level of EMR usage in an outpatient setting.  ...
(Date:3/23/2017)... , March 23, 2017 The report "Gesture Recognition ... Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, the ... a CAGR of 29.63% between 2017 and 2022. ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the ... million people each year. Especially those living in larger cities are affected by air ... one of the most pollution-affected countries globally - decided to take action. , “I ...
(Date:10/10/2017)... ... 2017 , ... For the second time in three years, ... Award. Representatives of the FirstHand program travelled to Washington, D.C. Tuesday, October 10th, ... mission is to change the trajectory of STEM education in America by dramatically ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... 13 prestigious awards honoring scientists who have made outstanding contributions to ... symposium during Pittcon 2018, the world’s leading conference and exposition for laboratory science, ...
(Date:10/9/2017)... Texas (PRWEB) , ... October ... ... study published on October 5, 2017, in the medical journal, Epilepsia, Brain ... with the gold standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) ...
Breaking Biology Technology:
Cached News: