HOME >> BIOLOGY >> NEWS
Virus known for its photo ops makes its movie screen debut

WEST LAFAYETTE, Ind. - High-resolution snapshots of a virus attacking its host - which have culminated in a movie of the process - could reveal secrets of viral infection and improve gene therapy techniques, according to a Purdue University research group.

Structural biologists including Michael G. Rossmann have obtained clearer pictures of how the T4 virus, long known to infect E. coli bacteria, alters its shape as it prepares to pierce its host's cell membrane. The complicated infection process requires a flower-like section of the virus, known as the baseplate, to shape-shift by dramatically changing the configuration of the numerous proteins that form it. The team has taken cryoelectron microscope images of the baseplate from different moments in the process and transformed them into a brief animated movie, helping scientists understand how infection occurs and possibly enabling them to apply this knowledge for the benefit of human patients in the future.

"Instead of a still photo of the baseplate, we now have a movie of it opening," said Rossmann, who is Henley Distinguished Professor of Biological Sciences in Purdue's School of Science. "A better understanding of the infection process is a step forward for fundamental science, but it also could allow scientists to alter the baseplate so that the virus could infect cells other than E. coli. T4 might then be used to deliver beneficial genes to damaged or infected human tissue."

The research was performed at Purdue and the Institute of Bioorganic Chemistry in Moscow by a team of scientists including first author Petr G. Leiman, Paul R. Chipman, Victor A. Kostyuchenko, Vadim V. Mesyanzhinov and Rossmann. The paper appears in the current (Aug. 20) issue of the scientific journal Cell, and it builds on research the team published last year regarding the baseplate of the T4 virus. This previous paper offered a close-up picture of the baseplate at a single moment in time, information that
'"/>

Contact: Michael Rossmann
mgr@indiana.bio.purdue.edu
765-494-4911
Purdue University
20-Aug-2004


Page: 1 2 3

Related biology news :

1. Viruses clear bacterial contamination in chickens
2. Viruses may be environmentally friendly decontaminants
3. The Virus-Cancer Link: Examining the Role of Viruses in the Development of Cancer
4. Virus researchers close in on the secret life of DNA
5. Virus beats food bug
6. West Nile Virus cases analyzed for prevalence and symptoms
7. West Nile Virus can cause polio-like symptoms
8. Antibodies critical for fighting West Nile Virus infection
9. CDC Telebriefing: Smallpox educational activities and West Nile Virus update
10. West Nile Virus capsid protein causes encephalitic inflammation by triggering cell suicide
11. Pennsylvanias West Nile Virus surveillance system gets an assist from NASA data

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/7/2018)... (PRWEB) , ... November 07, 2018 , ... ... research and advisory firm serving the life science industry. The event was attended ... of science” that advance biological research and drug discovery. The winners were determined ...
(Date:11/3/2018)... ... November 01, 2018 , ... ... New Challenges and New Opportunities, **Presented by FDAnews**, Dec. 6, 2018 – Kleinfeld, ... , Early bird pricing for Emerging Trends in Medical Device Regulation and Quality ...
(Date:10/31/2018)... TRIANGLE PARK, N.C. (PRWEB) , ... October 30, ... ... the appointment of Brad Heidinger to Director of Operations. With more than 20 ... executive with proven visionary leadership in the biomanufacturing industry. Heidinger joins Azzur from ...
Breaking Biology News(10 mins):
(Date:11/5/2018)... ... November 05, 2018 , ... GlycoMark, Inc., the ... professionals through its website, http://www.glycomark.com , as part of National Diabetes Month. ... option via the website in November from 9 a.m. – 5 p.m. ET ...
(Date:10/31/2018)... ... October 30, 2018 , ... Myoscience, ... at the Campbell Clinic in Memphis, Tennessee. This study enrolled 125 patients ... of care for managing pain after total knee replacement surgery (TKA). , The ...
(Date:10/25/2018)... ... October 24, 2018 , ... To prepare for radiological and ... will work Argentum Medical, LLC to repurpose its commercial Silverlon ® ... technology, the privately held company has been awarded a three-year, $8.4 million contract with ...
(Date:10/18/2018)... ... October 18, 2018 , ... R3 Stem Cell is ... day regenerative therapy training workshop. The discount is good through November 7th, 2018, with ... stem cell and PRP training workshop includes an amazing useful array of hands on ...
Breaking Biology Technology:
Cached News: