HOME >> BIOLOGY >> NEWS
Visualizing the central dogma

In 1958, five years after he helped discover the double helix structure of DNA, Francis Crick coined the term "Central Dogma" to characterize the all-important cellular processes whereby DNA is "transcribed" into RNA and RNA is "translated" into protein. Since then, researchers have typically examined individual aspects of the Central Dogma in isolation, by developing separate systems for studying transcription or translation. Now, researchers at Cold Spring Harbor Laboratory have developed the first system for viewing how the Central Dogma unfolds in its entirety, from DNA to RNA to protein, within living cells. The study appears in the March 5 issue of the journal Cell.

The researchers, led by Dr. David Spector, developed a multi-component, fluorescence microscopy imaging system in which the DNA near an inducible gene can be visualized, the messenger RNA (mRNA) encoded by the gene is labeled yellow, and the protein encoded by the mRNA is labeled blue. In short, the system's DNA, RNA, and proteins are labeled so that they glow different colors and can be seen with a microscope. The scientists then captured time-lapse images as the inducible gene was switched on: First, the gene's tightly coiled DNA adopted a more relaxed, open shape. Next, RNA could be seen accumulating and being spliced in the nucleus and exported to the cytoplasm. Finally, the proteins appeared.

Although scientists have known that the production of proteins based on the information stored in DNA involves dynamic interactions among many molecules that carry out gene transcription, RNA splicing and export, and translation, they have never before been able to simultaneously track all of the products of transcription and translation as they are produced and move throughout living cells.

Spector and his colleagues have used the method to detect specific events that transform the architecture of chromosomes from a transcriptionally silent state to an actively transcribe
'"/>

Contact: Peter Sherwood
sherwood@cshl.edu
516-367-6947
Cold Spring Harbor Laboratory
4-Mar-2004


Page: 1 2

Related biology news :

1. Visualizing Alzheimers disease
2. Visualizing protein synthesis in living neurons
3. Scientists sequence genome of kind of organism central to biospheres carbon cycle
4. Genes may be central to cocaine addiction
5. Newborn lambs central heating system could aid fat busting in humans
6. A link between thimerosal and the brain: Can vaccines affect central nervous system function?
7. Virginia Bioinformatics Institute central to Regional Center of Excellence
8. HAART therapy significantly prolongs survival in AIDS patients with central nervous system lymphoma
9. Researchers aim to centralize N.C. emergency room data to combat epidemics, bioterrorism
10. Acorda therapeutics receives NIH Phase 2 grant for central nervous system repair
11. UT Southwestern researchers ID key protein for communication within central nervous system

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/7/2018)... ... September 05, 2018 , ... Following up on the launch ... year, IPS-Integrated Project Services, LLC and G-CON Manufacturing have successfully designed and delivered ... solution provides a pre-fabricated modular cleanroom infrastructure for the drug manufacturers’ requirements for ...
(Date:8/31/2018)... ... August 30, 2018 , ... CallTower is pleased ... more than 20-years of telecommunications experience and over ten years in executive leadership. Prior ... acquired by CallTower in early 2018. , In this new role, Jason ...
(Date:8/29/2018)... CAMBRIDGE, Mass. (PRWEB) , ... August 28, 2018 ... ... QipWorks, today introduced an annual awards program that recognizes women of excellence in ... recipient. , Sponsored by QipWorks, the Johanna Dwyer Women in IP Award aims ...
Breaking Biology News(10 mins):
(Date:8/29/2018)... ... August 28, 2018 , ... Cognition Corporation ®, a software company ... for NAVIGATE2018 . , Ryan Ward, Director of Engineering at Zimmer Biomet, ... An experienced engineer and manager with Zimmer Biomet for almost 15 years, Mr. Ward ...
(Date:8/26/2018)... ... August 23, 2018 , ... LabRoots , ... from around the world, will host the 4th Annual Microbiology and Immunology Virtual ... and disciplines, encompassing various research areas including medicine, agriculture, and space. , ...
(Date:8/21/2018)... Conn. (PRWEB) , ... August 21, 2018 , ... The ... 40, an annual recognition of the fastest growing technology companies in Connecticut. This year’s ... be held on Wednesday, October 3, at the Connecticut Convention Center in Hartford. A ...
(Date:8/14/2018)... ... August 13, 2018 , ... Labconco Corporation manufactures laboratory equipment, ... In addition, Labconco produces other lab equipment, such as glassware washers and freeze ... and consistency in design and manufacturing. , Through this webinar, which is ...
Breaking Biology Technology:
Cached News: