Vitamin C transporter gene discovery in mice

Bethesda, Md. - In what could provide new clues to the causes underlying the serious complications associated with premature birth, scientists at the National Human Genome Research Institute (NHGRI) have discovered a possible link between reduced vitamin C availability during pregnancy, and the devastating respiratory failure and massive cerebral bleeding that can occur immediately following premature birth.

The study, published today in the journal Nature Medicine by doctors and scientists from NHGRIs Genetic Disease Research Branch, the National Institute of Digestive and Kidney Diseases (NIDDK), and the division of Neonatology at the University of Pennsylvania School of Medicine and Childrens Hospital, demonstrated that mice deprived of vitamin C during pregnancy and birth died almost immediately after birth from bleeding in the brain and respiratory failure.

In humans, intracerebral hemorrhage, lung complications and respiratory failure are frequent causes of serious morbidity and death in premature infants. Maturation of the lungs occurs during the final few months of human gestation. A child born before this maturation is at high risk for these complications in the immediate postnatal period.

What Im suggesting is that we need to take a look at whether vitamin C in human fetuses before birth, transported from the maternal circulation, is a normal physiological factor that helps to mature and protect the lungs and brain of newborn infants, said Dr. Robert Nussbaum, chief of the Genetic Disease Research Branch at NHGRI and co-author of the paper.

There may be a link between sub-clinical deficiencies in vitamin C in the mother that is, a deficiency not significant enough to cause scurvy and the problems that can occur when the fetus prepares to leave the womb. We dont know for sure. What Im suggesting is that the work in mice points to an area that needs to be investigated.

In the study, scientists created a mouse

Contact: Geoff Spencer
NIH/National Human Genome Research Institute

Page: 1 2 3

Related biology news :

1. Vitamins do little to prevent recurrent stroke
2. Vitamin C may protect against ulcer-causing bacteria, study finds
3. Vitamin D analog found to boost radiation
4. As Vitamin B-6 levels go down, numbers of DNA strand breaks go up
5. UC Riverside biochemists develop technology to increase Vitamin C in plants
6. Vitamin D may be crucial in preventing colon cancer
7. Vitamin E and aspirin delay heart disease in mice even with high cholesterol levels
8. Rat genes increase Vitamin C in plants
9. Vitamin C produces gene-damaging compounds, test-tube study in Science reports
10. Penn study finds signs folic acid and Vitamin B12 may lessen some ill effects of SMA
11. Vitamin deficiency may exacerbate motor neuron disease

Post Your Comments:

(Date:7/22/2020)... SANTA BARBARA, Calif. (PRWEB) , ... July 21, ... ... consulting firm driving digital transformation and innovation in technology and compliance, announces a ... and medical device companies must ensure every layer of their technology stack complies ...
(Date:7/4/2020)... ... , ... Aesthetics Biomedical (ABM), a leading aesthetics product development ... the products and treatments developed, but also the dedicated team behind the brands ... built by ABM have received several honors already for 2020, each of which ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... R&D, today announced that it has entered into a multi-year contract with ... to support their translational and clinical research strategy to discover and develop ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... PORTLAND, Ore. (PRWEB) , ... August 13, 2020 , ... ... announced the creation of its Scientific Advisory Board (SAB) to research the medical ... medical cannabis can be enhanced when combined with terpenes. The board is focused on ...
(Date:8/12/2020)... ... August 12, 2020 , ... ... International), a global leader in FDA compliance consulting has been named on its ... companies. The list represents a unique look at the most successful companies within ...
(Date:7/31/2020)... ... 2020 , ... R3 Stem Cell International is now offering patients the opportunity ... cells total, patients may choose which extremities they would like treated. , Several studies ... Disord. 2016). At R3 International, umbilical cord tissue is obtained from a lab with ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas Medicine, Inc. ... of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and ... a strategic partnership whereby Catalent will provide support for the development, manufacturing, and ...
Breaking Biology Technology:
Cached News: