HOME >> BIOLOGY >> NEWS
Vitamin D deficiency and bowel diseases connected

Research with mice at Penn State has demonstrated a connection between vitamin D deficiency and two bowel diseases that occur in one out of every 1,000 people in North America and Europe.

Dr. Margherita T. Cantorna, assistant professor of nutrition and director of the research project, says "Our experiments show that vitamin D deficiency worsens the symptoms of Chron's disease and ulcerative colitis. Treatment with Vitamin D for as little as two weeks lessens the symptoms of these inflammatory bowel diseases in mice."

Cantorna detailed her research in a paper, "Vitamin D Deficiency Exacerbates Experimental Inflammatory Bowel Disease," presented today (April 18) at the Experimental Biology conference in San Diego, Calif. Her co-authors are Carey Munsick, a Penn State undergraduate, and Candace Bemiss, a Penn State master's degree candidate in nutrition. Their paper is the first in which researchers report demonstrating a connection between vitamin D deficiency and inflammatory bowel disease (IBD).

In her team's experiments, mice genetically engineered to spontaneously develop the symptoms of either Chron's disease or ulcerative colitis were also made vitamin D deficient at birth. The mice were then either maintained deficient or given vitamin D supplements in their food to bring them up to the normal level. The treated mice had less bowel inflammation than the untreated mice did. In addition, the mice that did not receive the supplements began to die at seven weeks of age and by nine weeks more than half were dead. In contrast none of the mice that received the supplements died during the experiment period.

"Vitamin D deficiency is more common in people who have inflammatory bowel disease. In addition, the anti-inflammatory drugs often used to treat IBD can cause bone loss as a side effect," Cantorna says. "Vitamin D taken in combination with these drugs may be able to reduce the effective dose of anti-inflammatory needed to tr
'"/>

Contact: Barbara Hale
bah@psu.edu
814-865-9481
Penn State
17-Apr-2000


Page: 1 2 3

Related biology news :

1. Vitamins do little to prevent recurrent stroke
2. Vitamin C may protect against ulcer-causing bacteria, study finds
3. Vitamin D analog found to boost radiation
4. As Vitamin B-6 levels go down, numbers of DNA strand breaks go up
5. UC Riverside biochemists develop technology to increase Vitamin C in plants
6. Vitamin D may be crucial in preventing colon cancer
7. Vitamin C transporter gene discovery in mice
8. Vitamin E and aspirin delay heart disease in mice even with high cholesterol levels
9. Rat genes increase Vitamin C in plants
10. Vitamin C produces gene-damaging compounds, test-tube study in Science reports
11. Penn study finds signs folic acid and Vitamin B12 may lessen some ill effects of SMA

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Vitamin deficiency and bowel diseases connected

(Date:12/3/2014)... -- As part of our commitment to offering the ... announce the release of a new reader that will ... data that they need. The Atlas 2000 ... readers. Many such devices have serious shortcomings when it ... models force users to navigate numerous complicated steps in ...
(Date:11/21/2014)... C-Labs LLC, a leading provider of remote ... today announced the appointment of John Traynor ... strategic advisor to the firm, Mr. Traynor will now ... based out of the C-Labs office in ... Muench , Chief Executive Officer. Photo - ...
(Date:11/18/2014)... Md. , Nov. 17, 2014 The Parenteral ... and U.S. regulatory agencies will speak and at least seven ... Metrics Conference at the Omni Shoreham Hotel in ... pleased once again to have significant support from the regulatory ... Europe in our effort to help ...
Breaking Biology News(10 mins):Inception Technologies to Release New Biometric Reader 2C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2
(Date:12/15/2014)... , Dec. 15, 2014  Origin Agritech Limited (NASDAQ ... a technology-focused supplier of crop seeds in China ... for its fiscal year 2014 ended September 30, 2014, before ... The Company will host a teleconference on January 8, 2015, ... time to discuss the results. To participate in ...
(Date:12/13/2014)... MaRS and Virgin Unite Canada, the non-profit foundation of the ... support Canadian entrepreneurs tackling social and environmental challenges. Today, Sir ... MaRS Centre to announce the new partnership, which includes the ... has $1 million in seed capital provided by Virgin Unite ... Innovation Foundation, founded by Alison Lawton . ...
(Date:12/13/2014)... and TAICHUNG, Taiwan (PRWEB) December 12, 2014 ... less rosy indicators in overall global economic growth, Eugene ... optics and photonics , said in a featured talk ... on 5 December at the National Chung Hsing University ... which is being integrated into future energy supplies and ...
(Date:12/13/2014)... New York (PRWEB) December 13, 2014 ... its global network and Cold Chain capabilities, and is ... Tower in Paris, France, to serve Life Science clients ... facility equipped with a controlled-ambient warehouse, will provide 24/7 ... for vaccines and investigational drugs, patient-clinical specimens, API, following ...
Breaking Biology Technology:Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 2Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 3MaRS and Virgin Unite partner to invest in business as a force for good 2MaRS and Virgin Unite partner to invest in business as a force for good 3Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 2Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 3Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 4Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 5Quick Opens Office in France to Serve Life Science Community In France and Neighboring French-Speaking Countries 2
Cached News: