HOME >> BIOLOGY >> NEWS
Wake Forest investigator shows new way that alcohol affects brain

WINSTON-SALEM, N.C. A Wake Forest University School of Medicine researcher today challenged a commonly accepted view on how alcohol acts in the brain in a plenary session presentation at the Research Society on Alcoholism meeting in San Francisco.

Jeffrey Weiner Ph. D., 2001 winner of the society's Young Investigator Award, said many scientists had thought for years that one of the ways that alcohol works was in much the same way as benzodiazepines (such as Valium and Xanax) or barbiturates (such as Nembutal). "But recent data from our laboratory and others challenge this concept and suggest that alcohol may have more complex effects."

Weiner's work focuses on what is called the GABA synapse which he says contributes to many of alcohol's behavioral and cognitive effects, especially intoxication, dependence and withdrawal. "The GABA synapse is the main inhibitory synapse in the brain."

The synapse is the gap between individual nerve cells in the brain. Nerve cells communicate with each other across these synapses by using chemical transmitters.

GABA is one of several of those neurotransmitters, targeting what are known as GABA receptors. Barbiturates and benzodiazepines act only on these receptors, which is the source of their inhibitory or tranquilizing effect. Anesthetics also work on these receptors, as does alcohol.

But Weiner, a member of Wake Forest's Center for the Neurobehavioral Study of Alcohol, recorded extensive evidence that alcohol also affects the nerve cell in the region before the synapse, which is called a pre-synaptic interaction.

"Unless you really focus on all of these mechanisms, you don't get the full picture of what alcohol is doing," said Weiner, assistant professor of physiology and pharmacology. "By looking

at both pre- and post- synaptic mechanisms, we discovered a whole new way that that the sensitivity of the synapse to alcohol is regulated."

That makes alcohol "
'"/>

Contact: Robert Conn
rconn@wfubmc.edu
336-716-4587
Wake Forest University Baptist Medical Center
1-Jul-2002


Page: 1 2

Related biology news :

1. Forest managers can fight invasive species that come with roads
2. Forest fire sensor inspired by nature
3. Rutgers ecologists and Brooklyn Botanic Garden botanists to plan Beijing Olympics Forest Park
4. Virginia Tech and North Carolina State University to run Forest Nutrition Research Cooperative
5. Forest preservation work turns to Carolina hemlock
6. Nonnative Invasive Plants of Southern Forests
7. Wake Forest researcher identifies syndrome as leading cause of death in premature infants
8. Wake Forest scientists develop colony of mice that fight off virulent cancer
9. Forest fragmentation may increase Lyme disease risk
10. USDA Forest Service publishes wildland-urban interface assessment
11. Forests of the continental U.S. continue to fragment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)...  Veratad Technologies, LLC ( www.veratad.com ), an innovative ... verification solutions, announced today they will participate as a ... thru May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions ... evolving digital world, defining identity is critical to nearly ...
(Date:4/19/2017)... York , April 19, 2017 ... as its vendor landscape is marked by the presence ... market is however held by five major players - ... Together these companies accounted for nearly 61% of the ... the leading companies in the global military biometrics market ...
(Date:4/13/2017)... , April 13, 2017 According to a new ... Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, ... IAM Market is expected to grow from USD 14.30 Billion in 2017 ... (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... At its national board meeting ... I. Sheikh, the co-founder, CEO and chief research scientist of Minnesota-based Advanced Space ... membership in ARCS Alumni Hall of Fame . ASTER Labs is a ...
(Date:10/11/2017)... ... 11, 2017 , ... Personal eye wash is a basic first aid supply for any work ... which eye do you rinse first if a dangerous substance enters both eyes? It’s one ... with its unique dual eye piece. , “Whether its dirt and debris, or an ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... will be hosting a Webinar titled, “Pathology is going digital. Is your lab ... digital pathology adoption best practices and how Proscia improves lab economics and realizes ...
(Date:10/11/2017)... the Netherlands and LAGUNA HILLS, Calif. ... The Institute of Cancer Research, London ... use MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify patients ... trial known as MUK nine . The University of ... trial, which is partly funded by Myeloma UK, and ICR ...
Breaking Biology Technology:
Cached News: