HOME >> BIOLOGY >> NEWS
Wake Forest scientists develop colony of mice that fight off virulent cancer

ung, stomach and intestine.

But, said Cui, one male mouse unexpectedly remained free of the cancer despite repeated injections. The Wake Forest team was able to show this was genetic and to develop a colony from that single mouse. The colony, now about 700 mice, remains exclusively at Wake Forest. Meantime, the original mouse "remained healthy, cancer-free and eventually died of old age after a normal lifespan."

When the cancer-resistant mice were bred with normal partners, the researchers found that about half of their offspring were resistant to cancer cells, indicating that this genetic protection is dominant and is likely due to a change in one gene. The resistance continued in future generations.

Depending on the age of the mouse, some had complete resistance -- the cancer never got started -- while others displayed spontaneous regression -- the cancer started developing over a period of a couple of weeks, but then it rapidly disappeared in less than 24 hours.

"The mice became healthy and immediately resumed normal activities including mating," Cui said. They tested them again with another injection of the cancer cells. He said that once the mice developed the protection, they never again developed the cancer.

The researchers said the mouse model "represents a unique opportunity to examine cancer/host interactions."

Cui said the new mouse model also may help in solving another medical mystery -- why cancer becomes more common when people age. The usual explanation is that mutations accumulate in the body, leading to precancerous conditions that eventually become cancer.

But, he said, the mouse model suggests that the body's natural protection -- which scientists call host resistance -- declines with age.

"This is at a preliminary stage, but very promising," said Mark Willingham, MD., professor of pathology and a collaborator. "Our hope is that, some day, this will have an impact on human
'"/>

Contact: Robert Conn
rconn@wfubmc.edu
336-716-4587
Wake Forest University Baptist Medical Center
28-Apr-2003


Page: 1 2 3

Related biology news :

1. Forest managers can fight invasive species that come with roads
2. Forest fire sensor inspired by nature
3. Rutgers ecologists and Brooklyn Botanic Garden botanists to plan Beijing Olympics Forest Park
4. Virginia Tech and North Carolina State University to run Forest Nutrition Research Cooperative
5. Forest preservation work turns to Carolina hemlock
6. Nonnative Invasive Plants of Southern Forests
7. Wake Forest researcher identifies syndrome as leading cause of death in premature infants
8. Forest fragmentation may increase Lyme disease risk
9. USDA Forest Service publishes wildland-urban interface assessment
10. Forests of the continental U.S. continue to fragment
11. Forest fragmentation may increase lyme disease risk

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: