HOME >> BIOLOGY >> NEWS
Walking proteins need to rock and roll, new study finds

The inside of a living cell has been compared to a train station at rush hour, with enzymes, chromosomes and other internal components constantly being shuttled along tiny fibrous tracks called microtubules.

Unlike a congested city commute, cellular traffic is efficient and highly regulated - thanks in part to a group of proteins known as motor molecules that use microtubules to haul vital cargo through the cell.

In 1985, biologists identified a molecular motor called kinesin that has turned out to be responsible for a variety of critical hauling jobs, such as separating chromosomes during cell division and ferrying neurotransmitters inside nerve cells.

Studies have shown that while one end of a kinesin molecule holds onto its cargo, the other end uses a remarkable two-headed structure to grab the microtubule and pull the cargo forward - a process called "kinesin walking" (see web animations at http://www.scripps.edu/milligan/projects and http://mc11.mcri.ac.uk/wrongtrousers.html).

Researchers are interested in unraveling the mystery of how kinesins walk along microtubules, and whether defective walking contributes to a variety of human ailments - including spontaneous abortion, tumor growth, infertility and neurodegenerative diseases such as Alzheimer's and retinitis pigmentosa.

A study featured on the cover of the June issue of the journal Nature Structural Biology adds an important piece to the puzzle.

"There is a lot of interest in kinesin and how it works as a motor," says Stanford chemistry Professor W. E. Moerner, co-author of the June study. "Measurements have been made of the forces kinesin produces as it walks, but we'd like to know how it is oriented when it moves as well."

HEAD OVER HEAD

Kinesin walking is controlled by the breakdown of ATP - a molecule that pr
'"/>

Contact: Mark Shwartz
mshwartz@stanford.edu
650-723-9296
Stanford University
27-Jun-2001


Page: 1 2 3

Related biology news :

1. Walking sticks lost wings, then re-evolved them
2. Walking aids older womens arterial elasticity, helping heart
3. Walking, Climbing Wheelchair
4. New molecular link key to cellular proteins involved in cancer progression, other diseases
5. New dye directly reveals activated proteins in living cells
6. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
7. Scientists discover proteins involved in spread of HIV-1 infection
8. New mechanism for display of foreign proteins to immune system
9. Scientists visualise cellular handmaiden that restores shape to proteins
10. Hopkins scientists use blood proteins to detect ovarian cancer
11. Viral proteins may prevent bacterial infections

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... Delta (NYSE: DAL ) customers now can use fingerprints instead ... National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in ... the boarding process to allow eligible Delta SkyMiles Members who are enrolled ...
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at ... between startups and global businesses, taking place in ... startups will showcase the solutions they have built with IBM ... France is one of the most ... increase in the number of startups created between 2012 and ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights ... (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital ...
(Date:10/10/2017)... International research firm Parks Associates announced today that ... TMA 2017 Annual Meeting , October 11 in Scottsdale, ... security market and how smart safety and security products impact the competitive ... Parks Associates: Smart Home Devices: Main ... "The residential security market has experienced continued ...
(Date:10/10/2017)... ... October 10, 2017 , ... The ... prestigious awards honoring scientists who have made outstanding contributions to analytical ... during Pittcon 2018, the world’s leading conference and exposition for laboratory science, which ...
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting in North ... in Harvard University’s Departments of Physics and Astronomy, has been selected for membership in ... winning team for the 2015 Breakthrough Prize in Fundamental physics for the discovery of ...
Breaking Biology Technology:
Cached News: