HOME >> BIOLOGY >> NEWS
'Warm to the touch' gene found

A group of researchers from The Scripps Research Institute (TSRI) and the Genomics Institute of the Novartis Research Foundation (GNF) have identified and cloned the first-known gene that makes skin cells able to sense warm temperatures.

In an article appearing in the journal Science, a group led by Ardem Patapoutian of TSRI and Stuart Bevan of Novartis describes the protein the gene makes, a type of transient receptor potential (TRP) channel called "TRPV3." This membrane protein opens when it senses a certain temperature and allows ions to pass through and cause an electrical potential that signals the brain.

"This protein may be an important target for drugs," says Patapoutian, "because, like other TRP channels, it may be involved in inflammation and pain-mediation."

Significantly, TRPV3 is the first temperature-sensing molecule identified that becomes activated at warm and hot temperatures, 33 C (91.5 F) and above. And it is the first temperature-sensing channel found in keratinocytes, which are the major type of cell in the skin.

Previously, scientists had known that humans and other vertebrate animals use specialized neurons located in the spinal column that are connected to the skin and organs through long axons to sense temperature, pressure, and other physical stimuli. Expressed on these axons are the same sort of TRP channels as the one in the current study, and in the last few years scientists have identified them as the "molecular thermometers" that detect hot and cold temperatures in the skin and relay that information back to the brain.

Earlier this year, the TSRI and GNF group identified and cloned the genecalled TRPM8 that codes for the first-known signaling molecule that helps the body sense cold temperatures and the cooling compound, menthol. That led them in part to the current molecule.

They knew that TRPM8 detects cold. And another set of channels in the spinal cord were known to detect noxious hea
'"/>

Contact: Robin B. Clark
rclark@scripps.edu
858-784-8134
Scripps Research Institute
16-May-2002


Page: 1 2

Related biology news :

1. New signs of life found at the Poles
2. Key cell-death step found
3. European common frog found to use novel mating strategy
4. Byproduct of water-disinfection process found to be highly toxic
5. Genuine stem cells found in skin might treat hair loss, wounds
6. Flame retardants found on supermarket shelves
7. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
8. Genetic clues found for common congenital brain disorder
9. New clues to hereditary blinding disease found
10. Anti-bacterial additive found in Maryland streams
11. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2019)... ... March 28, 2019 , ... In the development of biosimilars, ... a path for this task. Despite this uncertainty, several manufacturers have been successful and ... the first part of this webinar, learn how analytical similarity is achieved in biosimilars ...
(Date:3/27/2019)... ... 2019 , ... Evan Holden , a shareholder in the Atlanta ... at the National Academy of Sciences (NAS) Roundtable on Biomedical Engineering Materials Applications (BEMA), ... firm’s award-winning Pharmaceutical, Medical Device & Health Care Litigation Practice , addressed, “Medical ...
(Date:3/25/2019)... ... 25, 2019 , ... Researchers have found multiple applications for ... came into use by the scientific community. Keck Graduate Institute (KGI) Assistant Professor ... combine the power of CRISPR’s nucleic acid targeting with the ultra sensitivity of ...
Breaking Biology News(10 mins):
(Date:4/8/2019)... , ... April 08, 2019 , ... US Capital ... a $15 million preferred equity investment in the privately held pharmaceutical company, S1 Biopharma ... drug, Lorexys, is targeted at female hypoactive sexual dysfunction disorder and is ready to ...
(Date:4/4/2019)... ... 03, 2019 , ... LeadingBiotech, an exclusive event series bringing ... its Boston CEO conference to be held May 28-29, 2019 at Boston’s Four ... high-level panels and discussions from past, present and future change-makers. , ...
(Date:3/27/2019)... ... ... In honor of National Nutrition Month, Lajollacooks4u has collaborated with the San Diego ... This month, Chef Jodi Abel appeared on two segments on KUSI’s Good Morning ... addressed the nutritional value of USDA’s MyPlate, a nutrition guide that simplifies the somewhat ...
(Date:3/23/2019)... , ... March 22, 2019 , ... ... LenS3 Multi-Angle Light Scattering (MALS) detector , offering a revolutionary approach for ... polymers, polysaccharides, proteins, and biopolymers. A novel optical design, a unique cell-block assembly, ...
Breaking Biology Technology:
Cached News: