HOME >> BIOLOGY >> NEWS
'Warm to the touch' gene found

t. Patapoutian and his team reasoned that one or more molecules like TRPV3 must be able to detect warm temperatures.

"We have shown for the first time that skin cells are capable of detecting heat through molecules similar to those in heat-sensing neurons," says Patapoutian.

Around 33 C, TRPV3 becomes activated, opens, and allows an influx of positively-charged ions into the cellan electrical signal that presumably alerts the brain of the temperature.

It is not known how this signal is communicated to the brain, since keratinocytes, unlike neurons, have no direct link with the central nervous system. Keratinocytes do, however, touch nerve fibers, and it may be through these contacts that the temperatures are communicatedsomething that the team is trying to verify.

The channel's similarity to another temperature-sensing ion channel called VR1 suggests that TRPV3 may be a target for pain therapeutics. VR1 is involved in inflammation and in communicating pain to the brain, and several compounds that block its action are currently under investigation for chronic pain indications.

Similarly, compounds that block TRPV3's action may also be useful for fighting chronic pain.


'"/>

Contact: Robin B. Clark
rclark@scripps.edu
858-784-8134
Scripps Research Institute
16-May-2002


Page: 1 2

Related biology news :

1. New signs of life found at the Poles
2. Key cell-death step found
3. European common frog found to use novel mating strategy
4. Byproduct of water-disinfection process found to be highly toxic
5. Genuine stem cells found in skin might treat hair loss, wounds
6. Flame retardants found on supermarket shelves
7. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
8. Genetic clues found for common congenital brain disorder
9. New clues to hereditary blinding disease found
10. Anti-bacterial additive found in Maryland streams
11. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2019)... ... ... In the development of biosimilars, the broad definition of the similarity concept in ... several manufacturers have been successful and numerous follow-on biologics are approved in the US ... analytical similarity is achieved in biosimilars based on recently approved products in the US. ...
(Date:3/27/2019)... ATLANTA (PRWEB) , ... March 26, 2019 , ... ... firm Greenberg Traurig, LLP , was a panelist at the National Academy of ... at NAS’ Keck Center. Holden, a member of the firm’s award-winning Pharmaceutical, Medical ...
(Date:3/25/2019)... ... March 25, 2019 , ... Researchers have found multiple applications ... it came into use by the scientific community. Keck Graduate Institute (KGI) Assistant ... to combine the power of CRISPR’s nucleic acid targeting with the ultra sensitivity ...
Breaking Biology News(10 mins):
(Date:3/18/2019)... ... 18, 2019 , ... For more than 15 years, USDM Life Sciences ... science companies to easily comply with FDA 21 CFR Part 11 and EMA EudraLex ... service delivering end-to-end GxP compliance from vendor audit through ongoing validation maintenance, including every ...
(Date:3/14/2019)... ... 14, 2019 , ... The growth in the number and complexity of regulations ... Regulatory intelligence (RI) systems are not keeping ... right Insights faster and cheaper. With a diversity of information sources, identifying and analyzing ...
(Date:3/14/2019)... ... 13, 2019 , ... Murrieta Genomics , the genomic sequencing business incubator, ... broader business experience to bear as genomic sequencing startups build their business models. , ... expertise that our Advisory Board brings to the table. Many of these experts would ...
(Date:3/12/2019)... ... 11, 2019 , ... Centura Health, the region’s health care ... in the nation, to offer needle-free blood draws for inpatients. , Littleton Adventist ... which staff showed compassion jumped up by an average of 15.4% during the ...
Breaking Biology Technology:
Cached News: