HOME >> BIOLOGY >> NEWS
Warren Pharmaceuticals publishes results of preclinical evaluation

OSSINING, N.Y., July 9, 2004--Warren Pharmaceuticals, Inc. (Warren), a company engaged in developing novel treatments for devastating injuries and diseases, today announced the publication of a study showing the effectiveness of its compounds in a variety of neurologic injury and disease models. Working in collaboration with its partner, the Danish pharmaceutical company H. Lundbeck A/S, and collaborators at the Mario Negri Pharmacological Institute (Milan, Italy), University of Messina (Messina, Italy) and Dokuz Eylul University (Izmir, Turkey), Warren has shown for the first time that separation of two distinct biological activities of erythropoietin (EPO) can be achieved by a variety of modifications to the molecule. The article, entitled "Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic" was published in today's issue of the journal Science.

EPO is a naturally-occurring protein that increases red blood cell production, and recombinant human EPO is marketed for the treatment of anemia. Millions of cancer patients and those in kidney failure have received EPO for treatment of low blood count, generating over $9 billion in annual worldwide sales. This compound has attracted special interest recently because of its newly discovered role in protecting tissues from diverse injuries. The surprising discovery several years ago by Warren scientists that EPO crosses the blood brain barrier opened the way for development of protective compounds that can safely be administered by injection. Despite a positive early clinical trial in human stroke, long-term use of EPO will be limited because of increased red cell and platelet counts above normal and the potential for blood clots or hypertension.

Warren and its collaborators have synthesized molecules exhibiting only the tissue-protective effects of EPO, with no effect on the classical EPO receptor. This permits the administration of and sustained use in non-anemic patien
'"/>

Contact: Betsy Abrams
babrams@warrenpharma.com
914-762-7586
Warren Pharmaceuticals, Inc.
8-Jul-2004


Page: 1 2 3

Related biology news :

1. Cyclis Pharmaceuticals reports studies defining new mechanism for potential cancer therapies
2. Final results of the two Zevalin pivotal trials in radioimmunotherapy for B cell Non-Hodgkins Lymphoma announced by IDEC Pharmaceuticals
3. Ribozyme Pharmaceuticals, Inc. Demonstrates Potent Activity Of A Ribozyme Targeted Against The Hepatitis C Virus
4. Idun Pharmaceuticals Identifies Cell Type And Molecular Pathway Involved In TransplantationRelated Liver Damage
5. Cubist Pharmaceuticals Describes New VITA™ Technology For Enabling Genomics For Drug Discovery
6. Vertex Pharmaceuticals/Yale Research Team Uses Gene Knockout Mice To Establish Role Of Caspase-9 In Neuronal Cell Death Pathway
7. Scientists At The Scripps Research Institute And R.W. Johnson Pharmaceuticals Develop New Antibacterial Agents
8. Vertex Pharmaceuticals Researchers Report Three-Dimensional Structure Of Hepatitis C Helicase Enzyme; Report In Structure
9. Pharmaceuticals Manufactured In Insect Larvae
10. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
11. Professor publishes book on historic mosquito wars

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... Report on Form 10-K on Thursday April 13, 2017 with the ... The ... section of the Company,s website at http://www.nxt-id.com  under "SEC Filings," ... 2016 Year Highlights: Acquisition of ...
(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... Rosalind™, the first-ever genomics analysis platform specifically designed for life science researchers ... honor of pioneering researcher Rosalind Franklin, who made a major contribution to ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia ... be hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” ... pathology adoption best practices and how Proscia improves lab economics and realizes an ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology ... drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription ... is able to cross the cell membrane and bind intracellular STAT3 and inhibit ...
(Date:10/10/2017)... 2017 International research firm Parks Associates announced today ... the TMA 2017 Annual Meeting , October 11 in ... home security market and how smart safety and security products impact the ... Parks Associates: Smart Home Devices: ... "The residential security market has experienced ...
Breaking Biology Technology:
Cached News: