HOME >> BIOLOGY >> NEWS
Warren Pharmaceuticals publishes results of preclinical evaluation

OSSINING, N.Y., July 9, 2004--Warren Pharmaceuticals, Inc. (Warren), a company engaged in developing novel treatments for devastating injuries and diseases, today announced the publication of a study showing the effectiveness of its compounds in a variety of neurologic injury and disease models. Working in collaboration with its partner, the Danish pharmaceutical company H. Lundbeck A/S, and collaborators at the Mario Negri Pharmacological Institute (Milan, Italy), University of Messina (Messina, Italy) and Dokuz Eylul University (Izmir, Turkey), Warren has shown for the first time that separation of two distinct biological activities of erythropoietin (EPO) can be achieved by a variety of modifications to the molecule. The article, entitled "Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic" was published in today's issue of the journal Science.

EPO is a naturally-occurring protein that increases red blood cell production, and recombinant human EPO is marketed for the treatment of anemia. Millions of cancer patients and those in kidney failure have received EPO for treatment of low blood count, generating over $9 billion in annual worldwide sales. This compound has attracted special interest recently because of its newly discovered role in protecting tissues from diverse injuries. The surprising discovery several years ago by Warren scientists that EPO crosses the blood brain barrier opened the way for development of protective compounds that can safely be administered by injection. Despite a positive early clinical trial in human stroke, long-term use of EPO will be limited because of increased red cell and platelet counts above normal and the potential for blood clots or hypertension.

Warren and its collaborators have synthesized molecules exhibiting only the tissue-protective effects of EPO, with no effect on the classical EPO receptor. This permits the administration of and sustained use in non-anemic patien
'"/>

Contact: Betsy Abrams
babrams@warrenpharma.com
914-762-7586
Warren Pharmaceuticals, Inc.
8-Jul-2004


Page: 1 2 3

Related biology news :

1. Cyclis Pharmaceuticals reports studies defining new mechanism for potential cancer therapies
2. Final results of the two Zevalin pivotal trials in radioimmunotherapy for B cell Non-Hodgkins Lymphoma announced by IDEC Pharmaceuticals
3. Ribozyme Pharmaceuticals, Inc. Demonstrates Potent Activity Of A Ribozyme Targeted Against The Hepatitis C Virus
4. Idun Pharmaceuticals Identifies Cell Type And Molecular Pathway Involved In TransplantationRelated Liver Damage
5. Cubist Pharmaceuticals Describes New VITA™ Technology For Enabling Genomics For Drug Discovery
6. Vertex Pharmaceuticals/Yale Research Team Uses Gene Knockout Mice To Establish Role Of Caspase-9 In Neuronal Cell Death Pathway
7. Scientists At The Scripps Research Institute And R.W. Johnson Pharmaceuticals Develop New Antibacterial Agents
8. Vertex Pharmaceuticals Researchers Report Three-Dimensional Structure Of Hepatitis C Helicase Enzyme; Report In Structure
9. Pharmaceuticals Manufactured In Insect Larvae
10. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
11. Professor publishes book on historic mosquito wars

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/22/2018)... ... September 21, 2018 , ... VTE can ... untreated, can lead to significant morbidity and mortality. VTE affects between 300-600,000 Americans ... autopsy. Further, PE is the leading cause of preventable hospital death and maternal ...
(Date:9/12/2018)... ... September 11, 2018 , ... Tennant ... introduce the new ChemXP™ line of high performance secondary containment coatings, designed to ... to provide Tennant Coatings’ elite certified installers with the needed solutions to protect ...
(Date:9/7/2018)... ... September 06, 2018 , ... Sensors Midwest ... show Sensors Expo & Conference , announces their partnership with Fraunhofer USA ... an IoT Enabled Industrial IoT Certification Program. Taking place on October 17, 2018 ...
Breaking Biology News(10 mins):
(Date:9/13/2018)... ... September 13, 2018 , ... Asymmetrex’s director, James L. ... have gotten in medicine, if we didn’t have the means to measure the number ... His answer, “Nowhere! And that is what’s holding up progress in stem cell ...
(Date:9/12/2018)... ... 11, 2018 , ... Sterlitech Corporation, a global leader in ... from Fluid Technology Solutions (FTS H2O) to their offering of filtration products. ... triacetate (CTA) material. The highly hydrophilic nature of the CTA FO membranes favors ...
(Date:9/7/2018)... ... September 06, 2018 , ... ... September 25th-28th is a meeting of “The industry’s preeminent event on novel drug ... discovery scientists powerful tools to study these emerging targets in a quest to ...
(Date:9/7/2018)... , ... September 06, 2018 , ... Akadeum Life Sciences ... spent his career as an executive and leader of numerous biotech companies. , ... therapy and biologics company acquired by Thompson Street Capital in St. Louis, MO. ...
Breaking Biology Technology:
Cached News: