HOME >> BIOLOGY >> NEWS
Weizmann Institute scientists win global competition in predicting protein-protein interactions

Rehovot, Israel June 24, 2002-- A team of scientists from the Weizmann Institute of Science achieved the best result in the CAPRI (Critical Assessment of Prediction of Interactions) Challenge, an international competition in which participants submit predictions of structures of protein-protein complexes prior to experimental determination. The competitors were given three prediction targets, and sixteen teams from around the world submitted possible solutions. The Weizmann team, consisting of Dr. Miri Eisenstein of the Chemical Services Unit and her students Efrat Ben-Zeev, Alex Berchanski, Alex Heifetz and Boaz Shapira (also students of Prof. Ephraim Katzir in the Department of Biological Chemistry), was the only group to submit an acceptable prediction for each of the three targets. Dr. Eisenstein won a similar competition as part of a Weizmann Institute team six years ago.

Prediction of the structure of protein-protein complexes is an increasingly prominent field of endeavor in the current post-genome era, since new sequences and links between proteins are now regularly being discovered. "Docking" is a predictive method that uses computer algorithms to create three-dimensional models of the interactions formed between two protein molecules when they make contact, or "dock", with one another. The CAPRI Challenge, which requires that all competitors predict interactions for the same unbound molecules, provides a useful basis of comparison of different docking algorithms. The participants are given the structures of individual molecules and are requested to submit their predictions for the resulting complexes by a certain date, after which the experimental structures are made public. An independent group of assessors tests and compares all the predictions.

Predicting the ultimate complex structure of two unbound protein molecules is an exceptionally difficult task, since the proteins change their shapes in response to one another's presence
'"/>

Contact: Jeffrey J. Sussman
jeffrey@acwis.org
212-895-7951
American Committee for the Weizmann Institute of Science
24-Jun-2002


Page: 1 2

Related biology news :

1. Weizmann scientists invention moves forward: Cancer diagnosis technique gets FDA clearance
2. Psoriasis treatment based on Weizmann Institute Research passes phase II clinical trials
3. Weizmann Institute scientists report why taste and smell differ among individuals
4. Weizmann Institute scienists find that stem cells in the bone marrow become liver cells
5. Weizmann institute scientists solve the 3-D structure of the enzyme involved in Gaucher disease
6. Prize to Weizmann Institute professor for landmark work in stem cell transplantation
7. New witchweed-fighting method, presented by CIMMYT and Weizmann Institute scientist
8. Vaccination following spinal cord injury: Innovative Weizmann Institute approach limits paralysis
9. Weizmann Institute scientists block loss of eyesight in animals with a glaucoma-like disease
10. Weizmann Institute researcher named to Israel Academy Of Sciences And Humanities
11. Weizmann Institute scientists develop a novel system for analyzing genetic data that mimics the human capacity for unsupervised learning

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... 13, 2017 UBM,s Advanced Design and Manufacturing ... feature emerging and evolving technology through its 3D Printing ... run alongside the expo portion of the event and ... demonstrations focused on trending topics within 3D printing and ... manufacturing event will take place June 13-15, 2017 at the ...
(Date:4/11/2017)... BEACH GARDENS, Fla. , April 11, 2017 ... identity management and secure authentication solutions, today announced ... contract by Intelligence Advanced Research Projects Activity (IARPA) ... for IARPA,s Thor program. "Innovation has ... onset and IARPA,s Thor program will allow us ...
(Date:4/11/2017)... , April 11, 2017 No two ... researchers at the New York University Tandon School ... Engineering have found that partial similarities between prints ... used in mobile phones and other electronic devices ... The vulnerability lies in the fact that ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... 22, 2017 , ... AESKU.GROUP, an innovation leader in ... Technologien GmbH, thereby expanding its product portfolio to include allergy and food intolerance ... atopic eczema or a food allergy. Allergies are escalating to epidemic proportions and ...
(Date:6/22/2017)... ... June 22, 2017 , ... For the months of ... a Spotlight series on “Cell Therapy Regulation” for its regenerative medicine ... on the unique regulatory challenges of stem cell medical research. , Stem cell ...
(Date:6/22/2017)... (PRWEB) , ... June 22, 2017 , ... The first ... took 20 years until the first data on cross-contamination of human cell lines with ... been an increasing issue in cell culture labs and is associated with dramatic consequences ...
(Date:6/22/2017)... ... June 22, 2017 , ... Charm Sciences, Inc. is pleased to ... was determined to be appropriate as a screening test at dairies and farms for ... EZ system, and the Charm EZ Lite system. These systems are a combination incubator ...
Breaking Biology Technology:
Cached News: