HOME >> BIOLOGY >> NEWS
Weizmann Institute scientists win global competition in predicting protein-protein interactions

Rehovot, Israel June 24, 2002-- A team of scientists from the Weizmann Institute of Science achieved the best result in the CAPRI (Critical Assessment of Prediction of Interactions) Challenge, an international competition in which participants submit predictions of structures of protein-protein complexes prior to experimental determination. The competitors were given three prediction targets, and sixteen teams from around the world submitted possible solutions. The Weizmann team, consisting of Dr. Miri Eisenstein of the Chemical Services Unit and her students Efrat Ben-Zeev, Alex Berchanski, Alex Heifetz and Boaz Shapira (also students of Prof. Ephraim Katzir in the Department of Biological Chemistry), was the only group to submit an acceptable prediction for each of the three targets. Dr. Eisenstein won a similar competition as part of a Weizmann Institute team six years ago.

Prediction of the structure of protein-protein complexes is an increasingly prominent field of endeavor in the current post-genome era, since new sequences and links between proteins are now regularly being discovered. "Docking" is a predictive method that uses computer algorithms to create three-dimensional models of the interactions formed between two protein molecules when they make contact, or "dock", with one another. The CAPRI Challenge, which requires that all competitors predict interactions for the same unbound molecules, provides a useful basis of comparison of different docking algorithms. The participants are given the structures of individual molecules and are requested to submit their predictions for the resulting complexes by a certain date, after which the experimental structures are made public. An independent group of assessors tests and compares all the predictions.

Predicting the ultimate complex structure of two unbound protein molecules is an exceptionally difficult task, since the proteins change their shapes in response to one another's presence
'"/>

Contact: Jeffrey J. Sussman
jeffrey@acwis.org
212-895-7951
American Committee for the Weizmann Institute of Science
24-Jun-2002


Page: 1 2

Related biology news :

1. Weizmann scientists invention moves forward: Cancer diagnosis technique gets FDA clearance
2. Psoriasis treatment based on Weizmann Institute Research passes phase II clinical trials
3. Weizmann Institute scientists report why taste and smell differ among individuals
4. Weizmann Institute scienists find that stem cells in the bone marrow become liver cells
5. Weizmann institute scientists solve the 3-D structure of the enzyme involved in Gaucher disease
6. Prize to Weizmann Institute professor for landmark work in stem cell transplantation
7. New witchweed-fighting method, presented by CIMMYT and Weizmann Institute scientist
8. Vaccination following spinal cord injury: Innovative Weizmann Institute approach limits paralysis
9. Weizmann Institute scientists block loss of eyesight in animals with a glaucoma-like disease
10. Weizmann Institute researcher named to Israel Academy Of Sciences And Humanities
11. Weizmann Institute scientists develop a novel system for analyzing genetic data that mimics the human capacity for unsupervised learning

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... 15, 2017  IBM (NYSE: IBM ) is introducing several ... dedicated to developing collaboration between startups and global businesses, taking ... During the event, nine startups will showcase the solutions they ... industries. France is ... with a 30 percent increase in the number of startups ...
(Date:5/16/2017)... May 16, 2017   Bridge Patient Portal ... and MD EMR Systems , an electronic ... for GE, have established a partnership to build ... and the GE Centricity™ products, including Centricity Practice ... These new integrations will allow healthcare ...
(Date:4/19/2017)... York , April 19, 2017 ... as its vendor landscape is marked by the presence ... market is however held by five major players - ... Together these companies accounted for nearly 61% of the ... the leading companies in the global military biometrics market ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... Philadelphia, PA (PRWEB) , ... October 10, 2017 ... ... University City Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. ... accept the award for Excellence in Volunteer Experience from US2020. , US2020’s mission ...
(Date:10/10/2017)... ... 2017 , ... The Pittcon Program Committee is pleased to ... who have made outstanding contributions to analytical chemistry and applied spectroscopy. Each award ... conference and exposition for laboratory science, which will be held February 26-March 1, ...
(Date:10/9/2017)... Texas (PRWEB) , ... October ... ... study published on October 5, 2017, in the medical journal, Epilepsia, Brain ... with the gold standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) ...
(Date:10/6/2017)... D.C. (PRWEB) , ... October 06, 2017 , ... ... will host a lunch discussion and webinar on INSIGhT, the first-ever adaptive clinical ... Principal Investigator, Dana-Farber Cancer Institute. The event is free and open to the ...
Breaking Biology Technology:
Cached News: