HOME >> BIOLOGY >> NEWS
Weizmann researchers find evidence that links molecular mechanism to Huntington's Disease

Weizmann researchers have found evidence that an enzyme called transglutaminase (TGase) may be the "smoking gun" behind the deadly disease Huntington's disease (HD). Their study is reported in the June 22 issue of the Proceedings of the National Academy of Sciences.

TGase occurs naturally throughout the body, and is catalyst for processes associated with healing, such as skin formation and wound healing. But a 1993 study by Prof. Howard Green (now of the Department of Cell Biology, Harvard Medical School, Boston) suggested that because of their polymerizing properties, they might also act as a catalyst for aggregating a protein associated with HD called Huntingtin (htt). Prof. Lawrence Steinman (then of the Weizmann Institute's Department of Immunology, now of Stanford University's Department of Neurological Science), together with Weizmann graduate student, Marcela Karpuj and a team of researchers in the United States, have now provided clear evidence of elevated TGase activity in the postmortem brains of HD patients.

Patients who suffer from HD have aggregations "visible clumps"of htt in their brains, but not in other tissues. This makes aggregated htt a good pathological indicator for the disease. Steinman, Karpuj, and the other members of the team decided to look for a correlation between clumps of htt and TGase among patients with HD. They found elevated TGase activity in the cortex, the cerebellum, and the brain nuclei--all areas in the brain where htt gets concentrated into nuclear inclusions. Correspondingly, they found reduced TGase activity in lymphoblastoid cells--areas where htt does not aggregate. TGase, therefore, appears to be the "smoking gun" that leads to the formation of nuclear inclusions (htt aggregations) in HD patients.

Their research is unique, because for the first time, researchers were able to report on TGase activity in the brains of HD patients rather than in guinea pigs or rats. They compared five postmortem brains of HD
'"/>

Contact: Ellen Shnidman
ellens@acwis.org
212-779-2500
American Committee for the Weizmann Institute of Science
21-Jun-1999


Page: 1 2 3

Related biology news :

1. Weizmann scientists invention moves forward: Cancer diagnosis technique gets FDA clearance
2. Psoriasis treatment based on Weizmann Institute Research passes phase II clinical trials
3. Weizmann Institute scientists report why taste and smell differ among individuals
4. Weizmann Institute scienists find that stem cells in the bone marrow become liver cells
5. Weizmann institute scientists solve the 3-D structure of the enzyme involved in Gaucher disease
6. Prize to Weizmann Institute professor for landmark work in stem cell transplantation
7. New witchweed-fighting method, presented by CIMMYT and Weizmann Institute scientist
8. Weizmann Institute scientists win global competition in predicting protein-protein interactions
9. Vaccination following spinal cord injury: Innovative Weizmann Institute approach limits paralysis
10. Weizmann Institute scientists block loss of eyesight in animals with a glaucoma-like disease
11. Weizmann Institute researcher named to Israel Academy Of Sciences And Humanities

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: