HOME >> BIOLOGY >> NEWS
What goes wrong in older eggs?

HANOVER, NH Dartmouth researchers have determined that the fruit fly Drosophila can be used for further study about why more mistakes occur during cell division as eggs become older. In humans, such errors can give rise to Down syndrome, a genetic disorder where people have one extra chromosome.

Sharon Bickel, assistant professor of biological sciences at Dartmouth, and her colleagues reported in the March 18 issue of Current Biology that fruit flies are an excellent model organism to study how age affects meiosis, the specialized cell division that gives rise to the egg and the sperm. In humans, the incidence of births of children with Down syndrome increases with the age of the mother, according to the National Down Syndrome Society.

"Age-related meiotic defects are hard to study in humans, because it's difficult to examine how this process deteriorates in females over a span of twenty years," said Bickel. "So we wanted to find out if we could utilize Drosophila as a model system to measure a similar phenomenon. Because flies are easy to grow in the lab, it's possible to look at thousands of flies and determine how frequently mistakes during meiosis are occurring."

Bickel's team specifically measured Drosophila meiotic nondisjunction, the term used to describe faulty cell division that can result in eggs that contain too many or too few chromosomes. During female meiosis in humans, nondisjunction can give rise to eggs with an extra copy of chromosome 21 and this accounts for 95 percent of all Down syndrome cases, according to the National Down Syndrome Society.

To determine whether or not meiotic errors increased in older eggs of fruit flies, the researchers devised a strategy with Drosophila to mimic the aging process that human eggs normally undergo. In humans, each female is born with all the eggs that will develop during her lifetime. As a woman ages, so do her eggs. Drosophila females, however, constantly produce and lay ne
'"/>

Contact: Sue Knapp
sue.knapp@dartmouth.edu
603-646-3661
Dartmouth College
2-May-2003


Page: 1 2

Related biology news :

1. Releasing pet fish into the wrong ocean proves a diaster
2. Mathematical rule said to be widely and wrongly used to forecast future beach erosion
3. ITA to AMA: Taxing tanning sends wrong health message to teens
4. Mom was wrong, UCLA/VA researcher concludes sleep not essential for learning
5. Pet trade wrong: Poaching major threat to parrots
6. Regular physical activity really does boost immune system in older men
7. Origin of West Indian insect eater much older than previously thought
8. Educational program increases some safety behaviors for older drivers
9. Ancient DNA mutations permitted humans to adapt to colder climates, UCI researchers find
10. Experts to demonstrate latest, cost-cutting computer-based caregiving for older Americans
11. New findings in yeast may reveal why growing older is the greatest carcinogen in humans

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology:
Cached News: