HOME >> BIOLOGY >> NEWS
When One Gene Has Two Roles, Its Second Function May Be Missed

r two copies of the gene for GATA-2. When two such mice are bred, one-fourth of the resulting embryos will lack both copies of the GATA-2 gene.

"These gene-knockout mice die early in embryogenesis," Engel said. The GATA-2 defect is unknown in humans, he said, presumably because it results in very early miscarriage. Mice and humans are very similar in the genetic mechanisms of their embryonic development.

In an effort to understand the signals that cause GATA-2 to turn on in the embryonic tissues that eventually produce blood cells, the researchers constructed a huge piece of DNA called an artificial chromosome. This artificial chromosome contains the GATA-2 gene plus long stretches of the DNA that brackets it in the normal chromosome. When the artificial chromosome was injected into mouse embryos that lacked GATA-2, blood cell formation was restored, or "rescued," and live mice were born.

Surprisingly, however, despite a normal blood forming system, all the mice died shortly after birth. Post-mortem examination revealed that they had malformations of the kidneys and bladder and other genitourinary structures.

"When we went back and looked at normal mice, we found that GATA-2 is expressed in a lot of the organs in the developing urogenital system," Engel said. GATA-2 had been thought to be important only for blood cell formation.

"And what was really surprising," he continued, "was that in the knockout mutants, the artificial chromosome, with GATA-2 and that enormous length of flanking DNA, was not sufficient to rescue the urogenital system."

The researchers conclude that GATA-2 expression in developing genitourinary tissues must be governed by a regulatory DNA sequence a vast distance away from the GATA-2 gene itself.

"The latter surprise is going to be disturbing to the scientific community, because everybody thinks that you control genes with relatively small pieces of DNA located right next to the gene," Engel said. "As far as I know,
'"/>

Contact: Bill Burton
b-burton@nwu.edu
847-491-3115
Northwestern University
12-Nov-1998


Page: 1 2 3

Related biology news :

1. Second call for proposals for the European Young Investigator Award
2. Second generation targeted antibodies - Its all in the binding
3. Secondary complications and restoration of function in SCI
4. Second EMBO International Practical Workshop for Science Teachers
5. NTP-CERHR announces the Second Phthalates Expert Panel Meeting to be held December 15-17, 1999
6. In Logged Forests, Hunting of Wildlife Becomes Deadly Second Harvest
7. Iron Supplemented Formula Milk Should Be Free For Inner City Children Into Their Second Year Of Life
8. Oregon Scientists Discover A Second Blood-Brain Barrier; Important Finding For Patients With Brain Cancers And Neurological Disorders
9. Phase III Results Suggest Potent Antiviral Activity For Vertex And Glaxo Wellcomes Second-Generation HIV Protease Inhibitor Agenerase TM
10. The Second Visible Human Project Conference
11. Researchers Take A Second Look At Homocysteines Link To Heart Disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... Inc., a global expert in SoC-based imaging and computing solutions, has ... features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® ... be showcased during the upcoming Medtec Japan at Tokyo Big Sight ... Las Vegas Convention Center April 24-27. ... Click here for an image of the ...
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... to grow at a CAGR of 30.37% during the period 2017-2021. ... been prepared based on an in-depth market analysis with inputs from ... prospects over the coming years. The report also includes a discussion ...
(Date:4/5/2017)... -- Today HYPR Corp. , leading innovator in ... the HYPR platform is officially FIDO® Certified . ... that empowers biometric authentication across Fortune 500 enterprises and ... 15 million users across the financial services industry, however ... suites and physical access represent a growing portion of ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... (PRWEB) , ... October 12, ... ... ) has launched Rosalind™, the first-ever genomics analysis platform specifically designed for ... complexity. Named in honor of pioneering researcher Rosalind Franklin, who made a ...
(Date:10/11/2017)... ... ... a basic first aid supply for any work environment, but most personal eye wash can ... a dangerous substance enters both eyes? It’s one less decision, and likely quicker response time ... , “Whether its dirt and debris, or an acid or alkali, getting anything in your ...
(Date:10/11/2017)... a leading provider of patient support solutions, has announced the ... which will launch this week. The VMS CNEs will address ... enhance the patient care experience by delivering peer-to-peer education programs ... to help women who have been diagnosed and are being ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... maternal age to IVF success. , After comparing the results from the fresh ...
Breaking Biology Technology:
Cached News: