HOME >> BIOLOGY >> NEWS
When One Gene Has Two Roles, Its Second Function May Be Missed

r two copies of the gene for GATA-2. When two such mice are bred, one-fourth of the resulting embryos will lack both copies of the GATA-2 gene.

"These gene-knockout mice die early in embryogenesis," Engel said. The GATA-2 defect is unknown in humans, he said, presumably because it results in very early miscarriage. Mice and humans are very similar in the genetic mechanisms of their embryonic development.

In an effort to understand the signals that cause GATA-2 to turn on in the embryonic tissues that eventually produce blood cells, the researchers constructed a huge piece of DNA called an artificial chromosome. This artificial chromosome contains the GATA-2 gene plus long stretches of the DNA that brackets it in the normal chromosome. When the artificial chromosome was injected into mouse embryos that lacked GATA-2, blood cell formation was restored, or "rescued," and live mice were born.

Surprisingly, however, despite a normal blood forming system, all the mice died shortly after birth. Post-mortem examination revealed that they had malformations of the kidneys and bladder and other genitourinary structures.

"When we went back and looked at normal mice, we found that GATA-2 is expressed in a lot of the organs in the developing urogenital system," Engel said. GATA-2 had been thought to be important only for blood cell formation.

"And what was really surprising," he continued, "was that in the knockout mutants, the artificial chromosome, with GATA-2 and that enormous length of flanking DNA, was not sufficient to rescue the urogenital system."

The researchers conclude that GATA-2 expression in developing genitourinary tissues must be governed by a regulatory DNA sequence a vast distance away from the GATA-2 gene itself.

"The latter surprise is going to be disturbing to the scientific community, because everybody thinks that you control genes with relatively small pieces of DNA located right next to the gene," Engel said. "As far as I know,
'"/>

Contact: Bill Burton
b-burton@nwu.edu
847-491-3115
Northwestern University
12-Nov-1998


Page: 1 2 3

Related biology news :

1. Second call for proposals for the European Young Investigator Award
2. Second generation targeted antibodies - Its all in the binding
3. Secondary complications and restoration of function in SCI
4. Second EMBO International Practical Workshop for Science Teachers
5. NTP-CERHR announces the Second Phthalates Expert Panel Meeting to be held December 15-17, 1999
6. In Logged Forests, Hunting of Wildlife Becomes Deadly Second Harvest
7. Iron Supplemented Formula Milk Should Be Free For Inner City Children Into Their Second Year Of Life
8. Oregon Scientists Discover A Second Blood-Brain Barrier; Important Finding For Patients With Brain Cancers And Neurological Disorders
9. Phase III Results Suggest Potent Antiviral Activity For Vertex And Glaxo Wellcomes Second-Generation HIV Protease Inhibitor Agenerase TM
10. The Second Visible Human Project Conference
11. Researchers Take A Second Look At Homocysteines Link To Heart Disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
(Date:3/31/2016)... March 31, 2016  Genomics firm Nabsys has completed ... Barrett Bready , M.D., who returned to the ... original technical leadership team, including Chief Technology Officer, ... Development, Steve Nurnberg and Vice President of Software and ... company. Dr. Bready served as CEO of ...
(Date:3/22/2016)... Ontario , PROVO and ... Newborn Screening Ontario (NSO), which operates the ... for molecular testing, and Tute Genomics and UNIConnect, ... management technology respectively, today announced the launch of a ... next-generation sequencing (NGS) testing panel. NSO ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young ... cancer. Members of the Class of 2016 were selected from a pool of ... More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... 2016 , ... STACS DNA Inc., the sample tracking software company, today announced ... has joined STACS DNA as a Field Application Specialist. , “I am thrilled ... COO of STACS DNA. “In further expanding our capacity as a scientific integrator, Hays ...
(Date:6/23/2016)... 2016 Andrew D ... http://doi.org/10.17925/OHR.2016.12.01.22 Published recently in ... from touchONCOLOGY, Andrew D Zelenetz , discusses ... care is placing an increasing burden on healthcare ... therapies. With the patents on many biologics expiring, ...
Breaking Biology Technology:
Cached News: