HOME >> BIOLOGY >> NEWS
When 'reaper' gene comes, cell death follows

SALT LAKE CITY - In what may be the cellular equivalent of watching the Grim Reaper in action, University of Utah School of Medicine researchers have shown that two "death activator" genes are essential for cell death when Drosophila (fruit flies) metamorphose from larvae to adults. Death of obsolete larval tissue is critical in insect metamorphosis.

The two genes--reaper (rpr) and hid (head involution defective)--act by overcoming the protective efforts of a death inhibitor, DIAP1. Once DIAP1 is disabled, the inexorable begins and larval tissues like the salivary glands are rapidly destroyed, according to Carl S. Thummel, Ph.D., professor of human genetics at the Eccles Institute of Human Genetics, and doctoral student Viravuth P. Yin. The two will publish their findings in the May 25 print edition of the Proceedings of the National Academy of Sciences. The article will appear online the week of May 17.

"They are true (cell) death genes in Drosophila that are critical for the destruction of larval tissue during metamorphosis," Thummel said.

The finding opens the possibility that someday death-inducing genes could be unloosed to specifically kill unwanted cells--such as tumors.

Cell death (apoptosis) begins when ecdysone, a steroid hormone, binds to its receptor, EcR/USP. This binding allows the receptor to activate three key regulatory genes--E93, BR-C, and E74A. Those genes turn on reaper and hid, which then deactivate the death inhibitor DIAP1. When DIAP1 is no longer functioning, cell death is unleashed in the salivary glands, leading to the destruction of larval tissue and their replacement by adult structures.

Ecdysone already was known to regulate a number of genes; and reaper and hid were known as death activators. But it had not been proved that those two genes are essential for salivary gland cell death to occur, and no roles were known for DIAP1 in preventing premature larval cell death. Ecdysone is the crit
'"/>

Contact: Cindy Fazzi
cindy.fazzi@hsc.utah.edu
801-581-7387
University of Utah Health Sciences Center
17-May-2004


Page: 1 2

Related biology news :

1. Key cell-death step found
2. Optimizing proteins death domain halts leukemia in laboratory study
3. Small, Smac-like molecule encourages death of cancer cells
4. Heartless worms hold clues to cardiac arrhythmias, sudden death
5. Ecologists help keep death off the roads
6. Researchers identify gene for a primary form of sudden infant death sydrome (SIDS)
7. Cell death protein has surprising role in cell migration
8. Improved nutrition could prevent more than half of the worlds child deaths annually
9. JGI, VBI help unravel sudden oak death & soybean disease
10. Virginia Bioinformatics Institute researcher advances fight against sudden oak death disease
11. Cell growth and death controlled by single pathway in lymphoma cancer model

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)... HAMPTON, Va. , Aug. 15 2017   ivWatch LLC ... effectiveness of intravenous (IV) therapy, today announced receipt of its ISO ... (QMS) developed by the International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for ... "This ...
(Date:5/23/2017)... the first robotic gym for the rehabilitation and functional motor sense evaluation ... Genoa, Italy . The first 30 robots will be available from ... . The technology was developed and patented at the IIT laboratories ... Technology thanks to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:4/19/2017)... ALBANY, New York , April 19, 2017 /PRNewswire/ ... highly competitive, as its vendor landscape is marked by ... in the market is however held by five major ... and Safran. Together these companies accounted for nearly 61% ... majority of the leading companies in the global military ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... of a United States multicenter, prospective clinical study that demonstrates the accuracy ... test capable of identifying clinically significant acute bacterial and viral respiratory tract ...
(Date:10/11/2017)... ... October 11, 2017 , ... At its national board ... Suneel I. Sheikh, the co-founder, CEO and chief research scientist of Minnesota-based Advanced ... for membership in ARCS Alumni Hall of Fame . ASTER Labs is ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ... hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” with ... adoption best practices and how Proscia improves lab economics and realizes an increase ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... the implantation and pregnancy rates in frozen and fresh in vitro fertilization ... progesterone and maternal age to IVF success. , After comparing the results from ...
Breaking Biology Technology:
Cached News: