HOME >> BIOLOGY >> NEWS
Why do schizophrenics smoke?

ARTICLE: "Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area"

S R Laviolette and D van der Kooy

Neurobiology Research Group, Department of Anatomy & Cell Biology, University of Toronto, Toronto, Canada

Correspondence to: SR Laviolette, Neurobiology Research Group, Department of Anatomy & Cell Biology, 1 King's College Circle, University of Toronto, Toronto, Canada M5S 1A8

Nicotine produces rewarding and aversive motivational effects in humans and other animal species. Here, the authors report that the mammalian ventral tegmental area (VTA) represents a critical neural substrate for the mediation of both the rewarding and aversive properties of nicotine. They demonstrate that direct infusions of nicotine into the VTA can produce both rewarding and aversive motivational effects. While the rewarding effects of higher doses of nicotine were not attenuated by dopamine (DA) receptor blockade, blockade of mesolimbic DA signalling with either systemic or intra-nucleus accumbens (NAc) neuroleptic pretreatment potentiated the sensitivity to nicotine's rewarding properties over a three-order-of-magnitude dose range. Furthermore, the behavioural effects of lower doses of intra-VTA nicotine were reversed, switching the motivational valence of nicotine from aversive to rewarding. These results suggest that blockade of mesolimbic DA signalling induced by neuroleptic medications may block selectively the aversive properties of nicotine, thus increasing the vulnerability to nicotine's rewarding and addictive properties by inducing a unique, drug-vulnerable phenotype.

Citation source: Molecular Psychiatry 2003 Volume 8, number 1, pages 50-59.

For further information on this work, please contact Dr. Steven R. Laviolette, Neurobiology Research Group, Department of Anatomy & Cell Biology, 1 King's College Circle, University of Toronto, Toronto,
'"/>

Contact: Aimee Midei
MolecularPsychiatry@mednet.ucla.edu
310-206-6739
Molecular Psychiatry
13-Feb-2003


Page: 1 2

Related biology news :

1. Genetics, alcohol sensitivity, and behavior
2. Genetics, stress and environmental cues influence relapse drinking
3. Targeted Genetics, M.D. Anderson Cancer Center And University Of Pittsburgh Report Phase I Clinical Trial Results Of Gene Therapy Treatment For Cancer
4. Belgian researchers explore revolutionary approach to angiogenesis
5. Tracing genes, biologists show lizard migration is traced to Florida
6. Certain genes boost fish oils protection against breast cancer
7. Fossil genes reveal how life sheds form and function
8. Missing genes may help explain why plague bacteria are so deadly
9. Do genes respond to global warming?
10. Genetic map of important tree genes outlined
11. Mitochondrial genes cause nuclear mischief

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/12/2016)... May 12, 2016 WearablesResearch.com , a ... the overview results from the Q1 wave of its ... wave was consumers, receptivity to a program where they ... a health insurance company. "We were surprised ... says Michael LaColla , CEO of Troubadour Research, ...
(Date:4/28/2016)... 2016 First quarter 2016:   ... with the first quarter of 2015 The gross margin ... (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... unchanged, SEK 7,000-8,500 M. The operating margin for 2016 ...
(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is ... has received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval ... Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods ...
(Date:6/23/2016)... --  EpiBiome , a precision microbiome engineering company, today ... from Silicon Valley Bank (SVB). The financing will allow ... drug development efforts, as well as purchase additional lab ... been an incredible strategic partner to us – one ... provide," said Dr. Aeron Tynes Hammack , EpiBiome,s ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... In a ... Hospital in Denmark detail how a patient who developed lymphedema after being treated for ... The results could change the paradigm for dealing with this debilitating, frequent side effect ...
Breaking Biology Technology:
Cached News: