HOME >> BIOLOGY >> NEWS
Why does caffeine delay exercise-induced fatigue?

If the researchers were correct, the CNS administration of caffeine will increase run time to fatigue, whereas NECA will reduce run time to fatigue. Furthermore, pretreatment with caffeine before NECA will weaken the fatigue-inducing effects of NECA.

The authors of "Central Nervous System Effects of Caffeine and Adenosine on Fatigue," are J. Mark Davis, Zuowei Zhao, Howard S. Stock, Kristen A. Mehl, James Buggy, and Gregory A. Hand, all from the Schools of Public Health and Medicine, University of South Carolina, Columbia, SC. Their findings appear in the February 2003 edition of the American Journal of Physiology Regulatory, Integrative and Comparative Physiology. The journal is one of 14 peer-reviewed publications produced monthly by the American Physiological Society (APS).

Methodology

Male Wistar rats, five weeks old and weighing 200-250 grams, were used in this study, and randomly assigned to intracerebroventricular or intraperitoneal injection groups. Rats were given two weeks of treadmill acclimation of running for 15 minutes a day. The treadmill speed was slowly increased from eight meters a minute, 7.5 percent grade at the beginning, progressing to 20 meters a minute at the end of the acclimation period. Gentle hand prodding and mild electric shock were combined to encourage the animals to run throughout the study.

After the first two weeks of acclimation, rats assigned to the intracerebroventricular group were anesthetized with pentobarbital sodium, and tubes were implanted bilaterally into the lateral ventricles. After seven days of recovery from surgery, the rats were again acclimated to treadmill running for another one to two weeks, until they were able to run easily for at least 15 minutes per day for 5 consecutive days at a speed of 20 meters a minute at a 7.5 percent grade. Animals that were unable to run at that pace were excluded.

Four drug treatments were used in the study: NECA, caffeine, caffeine
'"/>

Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
18-Mar-2003


Page: 1 2 3 4

Related biology news :

1. Why some neonates need caffeine
2. Researchers study metabolic, cardiovascular effects of caffeine consumed with naringin
3. The genetic basis for caffeine-induced anxiety discovered
4. UT Southwestern scientist explores caffeine-signaling activity in brain function
5. Findings conclude sustained caffeine intake negates the benefits of creatine supplements
6. Medicines, caffeine and antibacterial soap among contaminants found in American streams
7. Moderate caffeine use does not increase miscarriage risk but high caffeine use doubles risk
8. Pollutant causes delayed flowering in plants
9. Mammoths stranded on Bering Sea island delayed extinction
10. Pesticide delays sexual maturation
11. Genetics mutations resulting in delayed puberty are focus of MCG study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/19/2016)... 2016 Securus Technologies, a leading provider of ... investigation, corrections and monitoring, announced today that it has ... have an independent technology judge determine who has the ... tech/sophisticated telephone calling platform, and the best customer service. ... most of what we do – which clearly is ...
(Date:11/15/2016)... -- Research and Markets has announced the addition of ... to their offering. ... The global bioinformatics ... USD 6.21 Billion in 2016, growing at a CAGR of 21.1% ... market is driven by the growing demand for nucleic acid and ...
(Date:6/22/2016)... ANGELES , June 22, 2016 /PRNewswire/ ... identity management and verification solutions, has partnered ... edge software solutions for Visitor Management, Self-Service ... provides products that add functional enhancements ... partnership provides corporations and venues with an ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... , ... December 06, 2016 ... ... Great Point Partners ("GPP") portfolio company, today announced it has acquired the ... a subsidiary of Chiltern International and focuses on clinical trial drug packaging, ...
(Date:12/6/2016)... Ind. , Dec. 6, 2016 Zimmer ... "Company") today announced the pricing terms of its ... to $1.25 billion aggregate purchase price (excluding accrued and ... settlement date and excluding fees and expenses related ... the debt securities identified in the table below ...
(Date:12/6/2016)... Toronto, ON (PRWEB) , ... ... ... (“ProMIS” or the “Company”), a company focused on discovery and development of ... therapeutic candidates it is developing for Alzheimer’s disease (AD) inhibited the direct ...
(Date:12/5/2016)... ... December 05, 2016 , ... This composition patent, U.S. Patent ... The composition claims are not limited to any particular process to make ... polymers, carbon fibers, graphene, and other materials. A continuation application, U.S. Patent ...
Breaking Biology Technology:
Cached News: